Perindopril erbumine

Product Name: Perindopril erbumine
CAS No.: 107133-36-8
Chemical Name: Perindopril erbumine
Synonyms: Aceon;prindopril API;Perindopril ErbuMine (Aceon);Perindopril for stereochemical purity CRS;CoversuM;Perindoril;PrestariuM;Perinodopril;Pederindopril;Unii-1964X464oj
CBNumber: CB4500876
Molecular Formula: C23H43N3O5
Formula Weight: 441.61
MOL File: 107133-36-8.mol

More

Less

Perindopril erbumine Property

Melting point:: 126-128°C
storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL, clear
form: powder
color: White

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: NL5999600
HS Code: 2933999552

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0094
Product name: Perindopril erbumine
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $194
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1510889
Product name: Perindopril erbumine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $174.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000771
Product name: Perindopril for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000771
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000238
Product name: Perindopril tert-butylamine
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000238
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000207
Product name: Perindopril for stereochemical purity
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000207
Price: $153
Updated: 2024/03/01

More

Less

Perindopril erbumine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Aceon ,Solvay Pharmaceuticals Inc. ,USA

Uses

An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.

Uses

antibacterial

Definition

ChEBI: Perindopril erbumine is an addition compound. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a perindopril(1-).

Manufacturing Process

Heat 5 kg of 2-carboxyindole suspended in ethanol in the presence of sulfuric acid to boiling for 8 hours. Evaporate off take up the crystalline mass with hexane. After filtering off and drying, 5.3 kg of 2-ethoxycarbonylindole crystals are obtained. Melting point: 123°-125°C.
Suspend, in a reactor, 10 kg of 2-ethoxycarbonylindoline obtained previously in 110 liters of hydrochloric ethanol. Next, add 20 kg of granulated tin. Keep stirring for approximately 2 days at room temperature. Evaporate off the ethanol, take up the residue with water and add 110 liters of toluene. Stir for approximately 20 min. Alkalify with aqueous ammonia. Separate off the aqueous phase and extract once again with 150 liters of toluene. Combine the toluene phases and wash them with water. Separate off the toluene phases, filter. Remove the water by distilling the water-toluene azeotrope. Cool and pass through a stream of anhydrous HCl gas. Cool. Evaporate down and wash with pure toluene. Weight obtained of (R,S)-2-ethoxycarbonylindoline 10.11 kg. Yield: 84%.
2.15 kg of (R,S)-2-ethoxycarbonylindoline dissolved in ethanol are saponified with 12.5 liters of sodium hydroxide with stirring for 24 hours. After washing the alkaline solution, neutralize with concentrated hydrochloric acid. After filtering off, washing and drying, 1.57 kg of white crystals of the (R,S)-2carboxyindoline are obtained. Yield: 86%. Melting point: 188°-189°C.
6.05 kg of (R,S)-2-carboxyindoline are added to a solution of 4.49 kg of (+)α-methylbenzylamine in anhydrous ethanol. A white precipitated product is obtained which, after filtering off, is digested in refluxing isopropanol. After cooling, the solid is filtered off and washed with a little isopropanol. 1 kg of the obtained salt was dissolved in 5 liters of water and neutralizing with an aqueous hydrochloric acid solution. The precipitate is filtered off, washed with water and dried and (S)-2-carboxyindoline was prepared.
Place 25 kg of (S)-2-carboxyindoline, obtained previously, in 110 liters of methanol in a vessel. Keep stirred. Charge the rhodium (5% dry) catalyst into a mixer. Start up the stirring in a hydrogenator, charge the methanolic suspension of (S)-2-carboxyindoline by passing it through the mixer and rinse the assembly with water. Heat to 60°C and pressurize with hydrogen (30 bars). Filter off the catalyst on a single-plate filter. Collect the hydroalcoholic liquors in a reactor and evaporate the methanol off under vacuum. After concentrating, charge approximately 300 kg of dioxane. Heat to boiling and add water until a solution is obtained. Allow to cool. Filter off and dry. 22.3 kg of crystals of (2S,3aS,7aS)-2-carboxyoctahydroindole are obtained. Yield: 86.1%.
Place 35 kg of L-norvaline in approximately 300 kg of denatured ethanol in a reactor. Introduce approximately 60 kg of thionyl chloride, slowly and gradually. After stirring for a quarter of an hour, heat to reflux for 3 hours andthen evaporate off the ethanol under vacuum. Take up the residue with 300 liters of cyclohexane and heat to boiling. Allow to cool, filter, wash with cyclohexane and dry. 52.9 kg of ethyl L-norvalinate hydrochloride are obtained, that is a 97.6% yield.
Place 45 kg of ethyl N-norvalinate hydrochloride approximately 110 liters of water in a vessel equipped with a stirrer. Alkalify, then pour 23 kg of pyruvic acid very gradually into the solution obtained previously and stir the reaction mixture for 30 min. Place an aqueous suspension of charcoal containing 5% palladium and the alkaline solution of ethyl L-norvalinate obtained previously in a hydrogenation apparatus. Hydrogenate under pressure (30 bars) at room temperature for approximately one day. Filter under vacuum and evaporate the filtrate under reduced pressure, filter off and dry. Treat the residue obtained with ethanol; remove the insoluble material, consisting of sodium chloride, by filtration and rinse it with ethanol. Combine the ethanolic solutions; evaporate off the ethanol under reduced pressure and crystallize the residue from acetonitrile 34.3 kg of N-[(S)-1-carbethoxybutyl]-(S)-alanine are obtained, that is a 63.9% yield.
In a 30-liter reactor, reflux 12.5 kg of (2S,3aS,7aS)-2-carboxyperhydroindole, 50 kg of para-toluenesulfonic acid and 14.2 kg of benzyl alcohol and 38.4 kg of toluene, removing the water formed with the aid of a continuous separator. When no more water separates out, cool, filter off the precipitate of paratoluenesulfonate of the benzyl ester of (2S,3aS,7aS)-2carboxyoctahydroindole formed, and dry. Yield: 91.3%.
Add approximately 3.5 kg of triethylamine to a suspension of approximately 5 kg of para-toluenesulfonate of the benzyl ester of (2S,3aS,7aS)-2carboxyoctahydroindole in approximately 60 kg of ethyl acetate, followed by approximately 6 kg of 1-hydroxybenzotriazole, approximately 7.5 kg of the N[(S)-1-carbethoxybutyl]-(S)-alanine and approximately 7.0 kg of dicyclohexylcarbodiimide. Stir, cooling slightly for approximately 3 hours, then filter off the dicyclohexylurea formed and wash the organic phase with water. The dried organic phase is evaporated to dryness and benzyl ester of (2S,3aS,7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)propionyl}octahydroindole-2-carboxylic acid was obtained. Yield: 92.3%.
Dissolve, in a hydrogenator, 14 kg of benzyl ester of the (2S,3aS,7aS)-1-{2[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl}octahydroindole-2carboxylic acid in cyclohexane. Add the charcoal containing 5% palladium and approximately 50 liters of water. Hydrogenate at ordinary temperature and pressure until the theoretical volume of hydrogen has been absorbed. Filter, wash the insoluble material with cyclohexane, separate off the organic phase and wash the aqueous phase again with cyclohexane. Isolate the (2S,3aS,7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)propionyl}octahydroindole-2-carboxylic acid from the aqueous phase by freeze-drying.
In practice it is used combined with 2-methyl-2-propanamine.

brand name

Aceon (Solvay Pharmaceuticals).

Therapeutic Function

Antihypertensive

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Perindopril erbumine is an angiotensin converting enzyme (ACE) inhibitor; antihypertensive; becomes hydrolyzed in vivo to the active diacid metabolite; unlike the other ACE inhibitors, inhibits tumor growth in hepatocellular carcinoma cells due to suppression of VEGF levels; also suppresses angiotensin II production in vitro. Long-term therapy with this agent has a beneficial effect on the cerebral circulation by improving cerebral perfusion reserve in patients with previous minor stroke.

Safety Profile

A poison by intravenous route. Moderately toxic by ingestion, When heated to decomposition it emits toxic vapors of NOx.

Perindopril erbumine Preparation Products And Raw materials

Raw materials

Preparation Products

Perindoprilat

More

Less

Perindopril erbumine Suppliers

Austria 1 Canada 3 China 305 Europe 2 France 2 Germany 2 Greece 1 India 58 Japan 1 Nepal 1 Poland 1 Slovenia 1 South Korea 1 Spain 1 Ukraine 1 United Arab Emirates 1 United Kingdom 12 United States 34 Global 428

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Bachem Americas, Inc.

Tel: --
Fax: --
Email: sales.us@bachem.com
Country: United States
ProdList: 161
Advantage: 58

Selleck Chemicals LLC

Tel: --
Fax: --
Email: sales@selleckchem.com
Country: United States
ProdList: 1848
Advantage: 58

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

SHAMROCK INDUSTRIAL CO. LTD.

Tel: --
Fax: --
Email: pharma@shamrockindia.com
Country: United States
ProdList: 119
Advantage: 43

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

ACIC Fine Chemicals Inc.

Tel: --
Fax: --
Email: sales@acic.com
Country: United States
ProdList: 492
Advantage: 48

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

VARDA Biotech (P) Ltd.

Tel: --
Fax: --
Email: vijay@vardabiotech.com
Country: United States
ProdList: 208
Advantage: 66

Drefspharma Ltd.

Tel: --
Fax: --
Country: United States
ProdList: 6
Advantage: 38

More

Less

View Lastest Price from Perindopril erbumine manufacturers

Sinoway Industrial co., ltd.

Product: Perindopril 107133-36-8
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up / EP
Supply Ability: 20 tons
Release date: 2021-07-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Perindopril erbumine 107133-36-8
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%-101%
Supply Ability: 1000KGS
Release date: 2021-06-23

Baoji Guokang Bio-Technology Co., Ltd.

Product: Perindopril erbumine 107133-36-8
Price: US $2857.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 1T
Release date: 2021-06-03

107133-36-8, Perindopril erbumineRelated Search:

Indole-3-butyric acid tert-Butylamine Indometacin 2S-(2ALPHA,3ALPHA,BETA,7ALPHA,BETA-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID PHENYL METHYL ESTER Sunitinib Malate Lercanidipine Indole-3-acetic acid (S)-(-)-Indoline-2-carboxylic acid L-Octahydroindole-2-carboxylic acid N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanine Perindopril Carbonyl iron powder Perindoprilat Indolapril Perindopril erbumine-d4 PERINDOPRIL ACYL-B-D-GLUCURONIDE ALLYL-PERINDOPRIL-ACYL-D-GLUCURONATE Orbutopril

prindopril API

Perindopril erbumine

Aceon

Unii-1964X464oj

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt

Perindoril

Perindopril ErbuMine (Aceon)

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]aMino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid 2-Methyl-2-propanaMine

ButylaMiniperindopril

CoversuM

Perinodopril

Perinodpril ErbiMune

PrestariuM

Perindopril t-ButylaMine

1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,7aS)-, compd. with 2-methyl-2-propanamine (1:1)

Perindopril Erbumine (100 mg)

Perindopril Tables

2-Methylpropan-2-amine (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]propanoyl]octahydro-1H-indole-2-carboxylate

PERINDOPRIL T-BUTYLAMINE SALT

1-[2-(1-Ethoxycarbonylbutylamino)propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid 2-methyl-2-propanamine (1:1)

Perindopril tert-butylamine salt

Perindopril tert-butylamine CRS

Perindopril erbumine salt

Perindopril for peak identification CRS

Perindopril for stereochemical purity CRS

Perindopril Related Compound A (20 mg) ((2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid)

Perindopril erbumine USP/EP/BP

Pederindopril

Perindopril EP Impurity BB

Perindopril EP Impurity CC

Perindopril EP Impurity AA

Perindopril Erbumine (S-9490-3)

Perindopril ErbumineQ: What is Perindopril Erbumine Q: What is the CAS Number of Perindopril Erbumine Q: What is the storage condition of Perindopril Erbumine

Perindopril for peak identification (Y0000771)

Perindopril for stereochemical purity (Y0000207)

Perindopril Erbumine (1510889)

2-Methylpropan-2-amine (2S,3aS,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxopentan-2-yl)amino)propanoyl)octahydro-1H-indole-2-carboxylate

(6aR,9R,10aR)-9-[(methylsulfonyl)methyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline (pergolide sulfone)

2-Methylpropan-2-amine (2S,3aS,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxopentan-2-yl)amino)propanoyl)octahydro-1H-indole-2-carboxylate (Perindopril Impurity)

107133-36-8

C19H32N2O5xC4H11N

C23H43N3O5

C19H32N2O5C4H11N

4416

Amines

Chiral Reagents

Heterocycles

MOXAM

API

Intermediates & Fine Chemicals

Pharmaceuticals

Perindopril