Bispyrithione

ChemicalBook > CAS DataBase List > Bispyrithione

Product Name: Bispyrithione
CAS No.: 3696-28-4
Chemical Name: Bispyrithione
Synonyms: OMDS;osy20;omadineds;NSC 84740;NSC 677437;NSC 241716;ipyrithione;dipyrithione;BISPYRITHIONE;omadinedisulfide
CBNumber: CB4500917
Molecular Formula: C10H8N2O2S2
Formula Weight: 252.31
MOL File: 3696-28-4.mol

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Bispyrithione Property

Melting point:: 200.5°C (rough estimate)
Boiling point:: 582.8±25.0 °C(Predicted)
Density: 1.4423 (rough estimate)
refractive index: 1.5650 (estimate)
solubility: Methanol (Slightly), Water (Slightly, Heated, Sonicated)
pka: -0.77±0.10(Predicted)
form: solid
color: Gray or off-white paste
PH: 5.0-7.0(25°C,1%soln.)
Stability:: Hygroscopic
EPA Substance Registry System: Dipyrithione (3696-28-4)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D494253
Product name: 2,2''-Dithiobis(pyridine-N-oxide)
Packaging: 2mg
Price: $55
Updated: 2021/12/16

TRC

Product number: D494253
Product name: 2,2''-Dithiobis(pyridine-N-oxide)
Packaging: 10mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD165252
Product name: 2,2'-Dithiobis(pyridine-N-oxide) - 80%
Packaging: 100g
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: OR912173
Product name: 2,2'-Dithiobis(pyridine-N-oxide)
Packaging: 1g
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: J10433
Product name: 2,2'-Dithiobis(pyridine-N-oxide)
Packaging: 5mg
Price: $19.8
Updated: 2021/12/16

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Bispyrithione Chemical Properties,Usage,Production

Description

Bispyrithione is a pyrithione derivate used as bactericide and fungicide. The drug was marketed under the name Crimanex in the form of shampoo for the treatment of dandruff, however it is no longer available on the manufacturer website (Drossa Pharm . It is currently used as a pesticide.

Chemical Properties

beige to slightly grey powder and chunks

Uses

Bispyrithione can be used as an antibacterial; antifungal.

Application

Bispyrithione is a new antidandruff agent behind zinc pyrithione. It has similar chemical structure to zinc pyrithione, thus performs the same bactericidal property, with unique bactericidal actions, especially to mycetes, mild fungus and microzymes. It also can effectively disinfect oval bacil, candia albicans and other mycetes, while normal antimicrobials can't. It is not sensitive to metal ion and dissolves in water more easily than zinc pyrithione, which improves the compatibility and leads to best bactericidal effect. In 2-in-1 shampoo, it doesn't affect the pearly effect but enhance color stability.

Definition

ChEBI: Dipyrithione is a pyridinium ion.

Synthesis

1, drop into successively the 600g2-chloropyridine in the 5000ml four-hole boiling flask, 100g maleic and acid anhydrides, 600g hydrogen peroxide (35%) are opened to stir and are warmed up to 60 ℃ of successive reactions 12 hours, make 2-chloropyridine-N-oxide water solution.
2, the 2-chloropyridine that uses the 4000g2-methyl chloride to divide four extractions to make-N-oxide water solution merges extraction phase, and condensing crystal makes sterling 2-chloropyridine-N-oxide compound.
3, the 2-chloropyridine that purification is obtained-N-oxide compound, 430g sodium sulphite, the 2000g high purity water, drop into successively in the 5000ml four-hole boiling flask, open and stir, be warming up to 70 ℃, along with the carrying out of reaction added a part of yellow soda ash in good time, the PH of adjustment system is stabilized in 9～10, and reaction finishes 70 ℃ of insulations 2 hours, and insulation finishes to cool.Make the pyrithione sodium water solution.
4, use an amount of dilute sulphuric acid to adjust the PH to 2 of pyrithione sodium water solution system, separate out a large amount of white crystals.Filtrated stock cleans solid, namely gets pyrithione.
5, the pyrithione that the reaction of upper step is obtained, the 1000g ultrapure water drops in the plastic cup, the unlatching dispersed with stirring is even, then slowly splash into 220g hydrogen peroxide (35%), reaction is 1 hour about 50 ℃, make finished product Bispyrithione 497g (99.72%, five step of content overall yield of reaction: 74.6%).

Bispyrithione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bispyrithione manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: Bispyrithione 3696-28-4
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-06-19

Weijer International Trade (Hebei) Co., Ltd

Product: dipyrithione 3696-28-4
Price: US $200.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 50000kg/Month
Release date: 2023-03-14

WUXI HONOR SHINE CHEMICAL CO.,LTD

Product: Bispyrithione 3696-28-4
Price: US $0.00/Kg/Drum
Min. Order: 25Kg/Bag
Purity: 0.3
Supply Ability: 20tons
Release date: 2021-12-28

3696-28-4, BispyrithioneRelated Search:

Pyridine-N-oxide 2,4-Pyridinedicarboxylic acid, 2-Methyl ester 2-Pyridinemethanethiol 2-Methylbutyraldehyde 4-BROMO-5-NITROTHIOPHENE-2-CARBOXALDEHYDE 4,5,6-Trichloropyrimidine Dimethyl 4-nitrophthalate 2,4,6-Trifluorobenzoic acid 2,3,4,5-Tetrafluorobenzoic acid BOC-GAMMA-ABU-OH 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 4-Nitrophenylboronic acid 2-Fluoro-4-nitrobenzaldehyde 5-Bromo-6-methoxynicotinic acid methyl ester Dimethyl 2,4-pyridinedicarboxylate 3,5-DIHYDROXYPYRIDINE 2,4-PYRIDINECARBOXYLIC ACID, 4-METHYL ESTER 2,4-Pyridinedicarboxylic acid

BISPYRITHIONE

OMDS

Pyrithione disulfide

Pyrion disulfide

omadinedisulfide

omadineds

osy20

pyridine,2,2’-dithiobis-,1,1’-dioxide

pyridine,2,2’-dithiodi-,1,1’-dioxide

dipyrithione

NSC 84740

NSC 677437

NSC 241716

Di-2-pyridyl disulfide N,N'-dioxide

2,2'-DITHIOBIS(PYRIDINE-N-OXIDE), 97

2,2’-Dithiobis(pyridine-1-oxide)

2,2’-dithiodipyridine-1,1’-dioxide

ipyrithione

2,2'-DITHIOBIS(PYRIDINE-N-OXIDE)

2,2'-dithiobis(pyridine-n-oxide), 97

2,2'-Dithiobis(pyridine-N-oxide)

3696-28-4

C10H8N2O2S2

Antibacterial agent