BETAMETHASONE BENZOATE (200 MG)
- Product Name
- BETAMETHASONE BENZOATE (200 MG)
- CAS No.
- 22298-29-9
- Chemical Name
- BETAMETHASONE BENZOATE (200 MG)
- Synonyms
- W-5975;17-Benzoate;16-beta)-(11-beta;betamethasonebenzoate;Nintedanib Impurity 155;betamethasone17-benzoate;BETAMETHASONE BENZOATE (200 MG);Betamethasone Benzoate (1067307);BETAMETHASONE BENZOATE USP(CRM STANDARD);17-Benzoyloxy-9-fluoro-11β,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- CBNumber
- CB4501383
- Molecular Formula
- C35H41FO8
- Formula Weight
- 608.6936432
- MOL File
- 22298-29-9.mol
BETAMETHASONE BENZOATE (200 MG) Property
- Melting point:
- 225-228°
- alpha
- D24 +63.5° (dioxane)
- Boiling point:
- 641.0±55.0 °C(Predicted)
- Density
- 1.1732 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.93±0.70(Predicted)
Safety
- RIDADR
- UN 2811 6.1 / PGII
- WGK Germany
- 1
- HS Code
- 2937220000
- Toxicity
- LD50 scu-rat: 194 mg/kg TXAPA9 8,250,66
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1067307
- Product name
- Betamethasone benzoate
- Packaging
- 200mg
- Price
- $460
- Updated
- 2024/03/01
- Product number
- B327995
- Product name
- Betamethasone17-Benzoate
- Packaging
- 50mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- API0001695
- Product name
- BETAMETHASONE BENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.72
- Updated
- 2021/12/16
BETAMETHASONE BENZOATE (200 MG) Chemical Properties,Usage,Production
Originator
Benisone,Warner Lambert,US,1973
Uses
BETAMETHASONE BENZOATE (200 MG) is an analog of Betamethasone (B327000), a glucocorticoid used as an anti-inflammatory agent.
Definition
ChEBI: Betamethasone benzoate is a 21-hydroxy steroid.
Manufacturing Process
A mixture of 50 g of betamethasone, 50 cc of dimethylformamide, 50 cc of methyl orthobenzoate and 1.5 g of p-toluenesulfonic acid is heated for 24 hours on oil bath at 105°C while a slow stream of nitrogen is passed through the mixture and the methanol produced as a byproduct of the reaction is distilled off. After addition of 2 cc of pyridine to neutralize the acid catalyst the solvent and the excess of methyl orthobenzoate are almost completely eliminated under vacuum at moderate temperature. The residue is chromatographed on a column of 1,500 g of neutral aluminum oxide. By elution with ether-petroleum ether 30 g of a crystalline mixture are obtained consisting of the epimeric mixture of 17α,21-methyl orthobenzoates. This mixture is dissolved without further purification, in 600 cc of methanol and 240 cc of methanol and 240 cc of aqueous 2N oxalic acid are added to the solution. The reaction mixture is heated at 40°-50°C on water bath, then concentrated under vacuum, The residue, crystallized from acetone-ether, gives betamethasone 17-benzoate, MP 225°-231°C.
brand name
Uticort (Parke- Davis).
Therapeutic Function
Glucocorticoid
Safety Profile
Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of F-.
BETAMETHASONE BENZOATE (200 MG) Preparation Products And Raw materials
Raw materials
Preparation Products
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