ChemicalBook > CAS DataBase List > IBUFENAC
IBUFENAC
- Product Name
- IBUFENAC
- CAS No.
- 1553-60-2
- Chemical Name
- IBUFENAC
- Synonyms
- 2-(4-Isobutylphenyl)acetic acid;ibunac;medirex;isodilan;ibufenac;dytransin;NSC 99976;2-(4-Isobutylphenyl);p-isobutyl-alpha-toluicacid;(p-isobutylphenyl)aceticacid
- CBNumber
- CB4506742
- Molecular Formula
- C12H16O2
- Formula Weight
- 192.25
- MOL File
- 1553-60-2.mol
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IBUFENAC Property
- Melting point:
- 85-87°C
- Boiling point:
- 288.25°C (rough estimate)
- Density
- 1.0240 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.36±0.10(Predicted)
- color
- White to Off-White
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Safety
- HS Code
- 2916399090
- Toxicity
- LD50 orally in mice: 1.8 g/kg (Adams)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17874
- Product name
- Ibufenac
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $49
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17874
- Product name
- Ibufenac
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $109
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17874
- Product name
- Ibufenac
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $168
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17874
- Product name
- Ibufenac
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $310
- Updated
- 2024/03/01
TRC
- Product number
- I130000
- Product name
- Ibufenac
- Packaging
- 250mg
- Price
- $795
- Updated
- 2021/12/16
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IBUFENAC Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Uses
Used as an analgesic, anti-inflammatory.
Definition
ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatot xic side-effects.
Biological Activity
ibufenac is a dual cox-1 and -2 inhibitor.cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs), is an enzyme that is responsible for formation of prostanoids, such as thromboxane and prostaglandins.
in vitro
ibufenac was identified as an analog of the nsaid ibuprofen that could inhibit cox-1 and -2 activity with ic50 values of 17.4 and 13.1 μm, respectively [1].
in vivo
in a previous animal study, two new structural analogs, r3 and r4, along with their parent compounds, ibufenac and ibuprofen, were evaluated for their biopharmaceutical properties. aanti-inflammatory activity was evaluated by topically administering drugs to inhibit inflammation induced by using either clove oil or arachidonic acid. results showed that the rank order of activity was ibufenac approximately equal to ibuprofen > r3 approximately equal to r4 [2].
IC 50
17.4 and 13.1 μm for cox-1 and -2, respectively.
References
[1] gülcan, h. o.,nlü, s.,dimoglo, a., et al. marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes. arch.pharm.chem.life sci. 348, 55-61 (2015).
[2] rao cs, schoenwald rd, barfknecht cf, laban sl. biopharmaceutical evaluation of ibufenac, ibuprofen, and their hydroxyethoxy analogs in the rabbit eye. j pharmacokinet biopharm. 1992 aug;20(4):357-88.
[3] t. m. chalmers.
IBUFENAC Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IBUFENAC manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- IBUFENAC 1553-60-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- IBUFENAC 1553-60-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
1553-60-2, IBUFENACRelated Search:
methyl 2-(4-isobutylphenyl)acetate
Ibufenac Acyl-β-D-Glucuronide
ethyl 4-isobutylphenylacetate
Loxoprofen
IBUPROFEN SODIUM SALT
(S)-(+)-Ibuprofen
IBUFENAC
Ibuprofen
Lobuprofen
Butibufen
Metoxibutropate
Ibuprofen Acyl-b-D-glucuronide
(R)-(-)-IBUPROFEN
METHYL 2-(4-ISOBUTYLPHENYL)PROPANOATE
IBUPROFENPICONOL
IBUPROFEN, RS, [CARBOXYL-14C]
Isoprofen
Mexoprofen