IBUPROFEN SODIUM SALT
- Product Name
- IBUPROFEN SODIUM SALT
- CAS No.
- 31121-93-4
- Chemical Name
- IBUPROFEN SODIUM SALT
- Synonyms
- ibuprofensodium;Einecs 250-477-6;Sodium ibuprofen;IBUPROFEN SODIUM SALT;(±)-Ibuprofen-d3, SodiuM Salt;(±)-Ibuprofen-d3 (sodium salt);p-isobutylhydratropicacidsodiumsalt;p-isobutyl-hydratropicacisodiumsalt;sodiuM 2-(4-isobutylphenyl)propanoate;sodium 2-(4-isobutylphenyl)propionate
- CBNumber
- CB0116983
- Molecular Formula
- C13H17NaO2
- Formula Weight
- 228.26
- MOL File
- 31121-93-4.mol
IBUPROFEN SODIUM SALT Property
- Melting point:
- 110-112 °C
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- H2O: 100 mg/mL, may be clear to slightly hazy
- form
- Solid
- color
- White to Off-White
- Water Solubility
- H2O: 100mg/mL, clear to slightly hazy
- Stability:
- Stable. Incompatible with strong oxidizing agents
- CAS DataBase Reference
- 31121-93-4
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- MU6641000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I1892
- Product name
- Ibuprofen sodium salt
- Purity
- analytical standard, ≥98% (GC)
- Packaging
- 100g
- Price
- $196
- Updated
- 2025/07/31
- Product number
- I1892
- Product name
- Ibuprofen sodium salt
- Purity
- analytical standard, ≥98% (GC)
- Packaging
- 500g
- Price
- $722
- Updated
- 2025/07/31
- Product number
- I400158
- Product name
- Ibuprofen sodium salt
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- API0014433
- Product name
- IBUPROFEN SODIUM
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.28
- Updated
- 2021/12/16
IBUPROFEN SODIUM SALT Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].
Application
Ibuprofen sodium salt is a useful research chemical.
Biological Activity
Cyclooxygenase (COX) inhibitor th at has greater activity against COX-1 than against COX-2.
in vivo
Ibuprofen sodium (fed in animal feedings, 300 mg/kg, 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer[5].
Ibuprofen sodium (subcutaneous injection, 60 mg/kg, every second day for 15 days) reduces the risk of neuropathy in a rat model of chronic Oxaliplatin?induced peripheral neuropathy[6].
Ibuprofen sodium (oral administration, 20 mg/kg, every 12 hours, 5 doses total) decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise[7].
Ibuprofen sodium (oral administration, 35 mg/kg, twice daily) attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection[8].
| Animal Model: | Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum)[5] |
| Dosage: | 300 mg/kg, daily for 14 days |
| Administration: | Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly) |
| Result: | Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells. Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells. |
| Animal Model: | Oxaliplatin?induced peripheral neuropathy[6] |
| Dosage: | 60 mg/kg, every second day for 15 days |
| Administration: | Subcutaneous injection |
| Result: | Lowered sensory nerve conduction velocity (SNCV). |
IC 50
COX-1: 13 μM (IC50); COX-2: 370 μM (IC50)
References
[1] Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. DOI:10.1021/np970343j
[2] Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36(5):3237-43. DOI:10.1007/s13277-014-2952-3
[3] Sharon M Rymut, et al. Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L317-27. DOI:10.1152/ajplung.00126.2016
[4] Emmanuelle Bignon, et al. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process. Sci Rep. 2017 Aug 21;7(1):8885. DOI:10.1038/s41598-017-09406-8
[5] Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6(1):98. DOI:10.1186/s40425-018-0406-y
[6] Thomas Kr?ig?rd, et al. Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy. Exp Brain Res. 2019 Oct;237(10):2645-2651. DOI:10.1007/s00221-019-05615-x
[7] Sarah Ilkhanipour Rooney, et al. Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model. Am J Sports Med. 2016 Sep;44(9):2237-45. DOI:10.1177/0363546516646377
[8] M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141(1):186-92. DOI:10.1164/ajrccm/141.1.186
IBUPROFEN SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IBUPROFEN SODIUM SALT manufacturers
- Product
- IBUPROFEN SODIUM SALT 31121-93-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2023-02-10
- Product
- IBUPROFEN SODIUM SALT 31121-93-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-29