ChemicalBook > CAS DataBase List > IBUPROFEN SODIUM SALT

IBUPROFEN SODIUM SALT

Product Name: IBUPROFEN SODIUM SALT
CAS No.: 31121-93-4
Chemical Name: IBUPROFEN SODIUM SALT
Synonyms: ibuprofensodium;Einecs 250-477-6;Sodium ibuprofen;IBUPROFEN SODIUM SALT;(±)-Ibuprofen-d3, SodiuM Salt;(±)-Ibuprofen-d3 (sodium salt);p-isobutylhydratropicacidsodiumsalt;p-isobutyl-hydratropicacisodiumsalt;sodiuM 2-(4-isobutylphenyl)propanoate;sodium 2-(4-isobutylphenyl)propionate
CBNumber: CB0116983
Molecular Formula: C13H17NaO2
Formula Weight: 228.26
MOL File: 31121-93-4.mol

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IBUPROFEN SODIUM SALT Property

Melting point:: 110-112 °C
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: H₂O: 100 mg/mL, may be clear to slightly hazy
form: Solid
color: White to Off-White
Water Solubility: H2O: 100mg/mL, clear to slightly hazy
Stability:: Stable. Incompatible with strong oxidizing agents
CAS DataBase Reference: 31121-93-4

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: MU6641000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I1892
Product name: Ibuprofen sodium salt
Purity: analytical standard, ≥98% (GC)
Packaging: 100g
Price: $196
Updated: 2025/07/31

Sigma-Aldrich

Product number: I1892
Product name: Ibuprofen sodium salt
Purity: analytical standard, ≥98% (GC)
Packaging: 500g
Price: $722
Updated: 2025/07/31

TRC

Product number: I400158
Product name: Ibuprofen sodium salt
Packaging: 500mg
Price: $85
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014433
Product name: IBUPROFEN SODIUM
Purity: 95.00%
Packaging: 5MG
Price: $501.28
Updated: 2021/12/16

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IBUPROFEN SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].

Application

Ibuprofen sodium salt is a useful research chemical.

Biological Activity

Cyclooxygenase (COX) inhibitor th at has greater activity against COX-1 than against COX-2.

in vivo

Ibuprofen sodium (fed in animal feedings, 300 mg/kg, 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer^[5].
Ibuprofen sodium (subcutaneous injection, 60 mg/kg, every second day for 15 days) reduces the risk of neuropathy in a rat model of chronic Oxaliplatin?induced peripheral neuropathy^[6].
Ibuprofen sodium (oral administration, 20 mg/kg, every 12 hours, 5 doses total) decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise^[7].
Ibuprofen sodium (oral administration, 35 mg/kg, twice daily) attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection^[8].

Animal Model:	Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum)^[5]
Dosage:	300 mg/kg, daily for 14 days
Administration:	Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly)
Result:	Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells. Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells.

Animal Model:	Oxaliplatin?induced peripheral neuropathy^[6]
Dosage:	60 mg/kg, every second day for 15 days
Administration:	Subcutaneous injection
Result:	Lowered sensory nerve conduction velocity (SNCV).

IC 50

COX-1: 13 μM (IC₅₀); COX-2: 370 μM (IC₅₀)

References

[1] Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. DOI:10.1021/np970343j
[2] Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36(5):3237-43. DOI:10.1007/s13277-014-2952-3
[3] Sharon M Rymut, et al. Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L317-27. DOI:10.1152/ajplung.00126.2016
[4] Emmanuelle Bignon, et al. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process. Sci Rep. 2017 Aug 21;7(1):8885. DOI:10.1038/s41598-017-09406-8
[5] Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6(1):98. DOI:10.1186/s40425-018-0406-y
[6] Thomas Kr?ig?rd, et al. Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy. Exp Brain Res. 2019 Oct;237(10):2645-2651. DOI:10.1007/s00221-019-05615-x
[7] Sarah Ilkhanipour Rooney, et al. Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model. Am J Sports Med. 2016 Sep;44(9):2237-45. DOI:10.1177/0363546516646377
[8] M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141(1):186-92. DOI:10.1164/ajrccm/141.1.186

IBUPROFEN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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IBUPROFEN SODIUM SALT Suppliers

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View Lastest Price from IBUPROFEN SODIUM SALT manufacturers

Dingwang Technology (Wuhan) Co., Ltd.

Product: IBUPROFEN SODIUM SALT 31121-93-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2023-02-10

Shaanxi Dideu Medichem Co. Ltd

Product: IBUPROFEN SODIUM SALT 31121-93-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-29

31121-93-4, IBUPROFEN SODIUM SALTRelated Search:

L-Arginine acetylsalicylate Diclofenac sodium 4-Propylphenylacetic acid 2-(4-Methylphenyl)propanoic acid IBUPROFEN SODIUM SALT Sodium phenylacetate IBUFENAC Loxoprofen sodium 2-(4-isobutylphenyl)propionaldehyde Ibuprofen 4-Methylphenylacetic acid Phenylacetic acid (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID 2-(4-ethylphenyl)acetic acid (4-ethylphenyl)acetaldehyde (2RS)-2-(4-ISOBUTYLPHENYL)PROPAN-1-OL (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID

IBUPROFEN SODIUM SALT

alpha-methyl-4-(2-methylpropyl)-benzeneaceticacisodiumsalt

ibuprofensodium

p-isobutylhydratropicacidsodiumsalt

ALPHA-METHYL-4-[2-METHYLPROPYL]BENZENEACETIC ACID SODIUM SALT

ALPHA-METHYL-4-(ISOBUTYL)PHENYLACETIC ACID SODIUM SALT

p-isobutyl-hydratropicacisodiumsalt

sodium 2-(4-isobutylphenyl)propionate

α-methyl-4-(isobutyl)phenylacetic acid

(±)-Ibuprofen-d3, SodiuM Salt

sodiuM 2-(4-isobutylphenyl)propanoate

2-(4-Isobutylphenyl)propionic acid sodium salt

2-(p-Isobutylphenyl)propionic acid sodium salt

Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, sodium salt (9ci)

Einecs 250-477-6

Hydratropic acid, p-isobutyl-, sodium salt

Sodium ibuprofen

Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-,sodiuM salt

(+/-)-Ibuprofen-d3, Sodium Salt (a-methyl-d3)

sodium,2-[4-(2-methylpropyl)phenyl]propanoate

(±)-Ibuprofen-d3 (sodium salt)

31121-93-4

C13H18O2Na

C13H17O2Na

C13H17NaO2

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