1-METHYL-1H-INDOLE-4-CARBALDEHYDE
- Product Name
- 1-METHYL-1H-INDOLE-4-CARBALDEHYDE
- CAS No.
- 133994-99-7
- Chemical Name
- 1-METHYL-1H-INDOLE-4-CARBALDEHYDE
- Synonyms
- 1-METHYL-1H-INDOLE-4-CARBALDEHYDE;1-methyl-1H-indol-4-carboxaldehyde;1H-Indole-4-carboxaldehyde, 1-methyl-;1H-Indole-4-carboxaldehyde, 1-methyl- (9CI);1-methyl-1H-indole-4-carbaldehyde(SALTDATA: FREE)
- CBNumber
- CB4589545
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 133994-99-7.mol
1-METHYL-1H-INDOLE-4-CARBALDEHYDE Property
- Boiling point:
- 318.7±15.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to brown <40°C Solid,>40°C Liquid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M221745
- Product name
- 1-Methyl-1H-indole-4-carbaldehyde
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M221745
- Product name
- 1-Methyl-1H-indole-4-carbaldehyde
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- Z4100
- Product name
- 1-Methyl-1H-indole-4-carbaldehyde
- Packaging
- 250mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 036759
- Product name
- 1-Methyl-1H-indole-4-carbaldehyde
- Packaging
- 500mg
- Price
- $252
- Updated
- 2021/12/16
- Product number
- CHM0018145
- Product name
- 1-METHYL-1H-INDOLE-4-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $726
- Updated
- 2021/12/16
1-METHYL-1H-INDOLE-4-CARBALDEHYDE Chemical Properties,Usage,Production
Synthesis
1074-86-8
74-88-4
133994-99-7
a) Synthesis of 1-methyl-1H-indole-4-carboxaldehyde: Sodium hydride (171 mg, 60% oil dispersion, 4.27 mmol) was added batchwise to an anhydrous N,N-dimethylformamide (DMF, 6.5 mL) solution of 1H-indole-4-carboxaldehyde (413 mg, 2.85 mmol) under argon protection. The reaction mixture was stirred at room temperature for 40 min. Subsequently, iodomethane (0.36 mL, 5.78 mmol) was slowly added dropwise and the reaction continued to be stirred at room temperature for 12 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (25 mL) and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, washed sequentially with water (20 mL) and saturated saline (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a yellow oily crude product. Purification by silica gel column chromatography (eluent: dichloromethane) gave 1-methyl-1H-indole-4-carboxaldehyde (452 mg, 99% yield) as yellow oil.1H NMR (400 MHz, DMSO-d6) δ 10.20 (s, 1H), 7.84 (d, J = 8.0 Hz, 1H), 7.68 (d, J = 7.2 Hz, 1H), 7.58 (d, J = 7.2 Hz, 1H). 7.58 (d, J = 2.8 Hz, 1H), 7.38-7.34 (m, 1H), 7.08 (d, J = 3.2 Hz, 1H), 3.87 (s, 3H).
References
[1] Patent: WO2007/53131, 2007, A2. Location in patent: Page/Page column 178
[2] European Journal of Medicinal Chemistry, 2017, vol. 134, p. 13 - 23
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2060 - 2079
[4] Journal of Organometallic Chemistry, 2011, vol. 696, # 5, p. 1072 - 1083
[5] Patent: WO2012/47702, 2012, A1. Location in patent: Page/Page column 32
1-METHYL-1H-INDOLE-4-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-METHYL-1H-INDOLE-4-CARBALDEHYDE manufacturers
- Product
- 1-METHYL-1H-INDOLE-4-CARBALDEHYDE 133994-99-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01