ChemicalBook > CAS DataBase List > ELEUTHEROSIDE B1(RG)

ELEUTHEROSIDE B1(RG)

Product Name: ELEUTHEROSIDE B1(RG)
CAS No.: 16845-16-2
Chemical Name: ELEUTHEROSIDE B1(RG)
Synonyms: ELEUTHEROSIDE B1(RG);Eleutheroside B1, 10 mM in DMSO;2H-1-Benzopyran-2-one,7-(a-D-glucopyranosyloxy)-6,8-dimethoxy-;2H-1-Benzopyran-2-one, 7-(α-D-glucopyranosyloxy)-6,8-dimethoxy-;6,8-Dimethoxy-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one;Eleutheroside B 1,Influenza Virus,anti-inflammatory,virus,host,Eleutheroside B1,anti-influenza,Eleutheroside B-1,Inhibitor,genes,biosynthesis,inhibit
CBNumber: CB4655037
Molecular Formula: C17H20O10
Formula Weight: 384.34
MOL File: 16845-16-2.mol

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ELEUTHEROSIDE B1(RG) Property

Boiling point:: 675.0±55.0 °C(Predicted)
Density: 1.524±0.06 g/cm3(Predicted)
storage temp.: 4°C, away from moisture and light
pka: 12.65±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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ELEUTHEROSIDE B1(RG) Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in chloroform, derived from the dried rhizome of Acanthopanax senticosus.

Uses

Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50?value of 64-125?μg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities[1].

Biological Activity

Eleutheroside B1, a coumarin compound, has broad-spectrum anti-human influenza virus (influenza virus) activity with IC50 values of 64-125μg/ml. It mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits mRNA expression of multiple chemokine genes and influenza virus nucleoprotein (NP) gene with low cytotoxicity. Has antiviral and anti-inflammatory activity.

in vitro

Eeutheroside B1 (100 μg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells.

RT-PCR

Cell Line:	Virus-infected A549 cells
Concentration:	100 μg/ml
Incubation Time:	24 hours
Result:	The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased.

References

[1] Yan W, et al. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med.?2018?Nov;42(5):2776-2792. DOI:10.3892/ijmm.2018.3863

ELEUTHEROSIDE B1(RG) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ELEUTHEROSIDE B1(RG) manufacturers

Career Henan Chemical Co

Product: 2H-1-Benzopyran-2-one,7-(a-D-glucopyranosyloxy)-6,8-dimethoxy- 16845-16-2
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

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ELEUTHEROSIDE B1(RG)

2H-1-Benzopyran-2-one,7-(a-D-glucopyranosyloxy)-6,8-dimethoxy-

2H-1-Benzopyran-2-one, 7-(α-D-glucopyranosyloxy)-6,8-dimethoxy-

6,8-Dimethoxy-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one

Eleutheroside B 1,Influenza Virus,anti-inflammatory,virus,host,Eleutheroside B1,anti-influenza,Eleutheroside B-1,Inhibitor,genes,biosynthesis,inhibit

Eleutheroside B1, 10 mM in DMSO

16845-16-2