ChemicalBook > CAS DataBase List > 2H-PYRAZOLE-3-CARBALDEHYDE

2H-PYRAZOLE-3-CARBALDEHYDE

Product Name
2H-PYRAZOLE-3-CARBALDEHYDE
CAS No.
3920-50-1
Chemical Name
2H-PYRAZOLE-3-CARBALDEHYDE
Synonyms
1H-PYRAZOLE-3-CARBALDEHYDE;1H-PYRAZOLE-5-CARBALDEHYDE;Pyrazole-3-carboxaldehyde;DKFELEX0322;3-formylpyrazole;RARECHEM AM LA 0023;PYRAZOLE-3-ALDEHYDE;3-Formyl-1H-pyrazole;Pyrazol-3-carbaldehyde;PYRAZOLE-3-CARBALDEHYDE
CBNumber
CB4670896
Molecular Formula
C4H4N2O
Formula Weight
96.09
MOL File
3920-50-1.mol
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2H-PYRAZOLE-3-CARBALDEHYDE Property

Melting point:
149.0 to 153.0 °C
Boiling point:
300.0±13.0 °C(Predicted)
Density 
1.323
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
11.20±0.10(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C4H4N2O/c7-3-4-1-2-5-6-4/h1-3H,(H,5,6)
InChIKey
ICFGFAUMBISMLR-UHFFFAOYSA-N
SMILES
N1C=CC(C=O)=N1
CAS DataBase Reference
3920-50-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-36/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933119000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS009918
Product name
1<I>H</I>-Pyrazole-3-carbaldehyde
Purity
Aldrich<SUP>CPR</SUP>
Packaging
50 mg
Price
$107
Updated
2025/07/31
Sigma-Aldrich
Product number
CDS009918
Product name
1H-Pyrazole-3-carbaldehyde
Purity
AldrichCPR
Packaging
50mg
Price
$104
Updated
2024/03/01
TCI Chemical
Product number
P2261
Product name
Pyrazole-3-carboxaldehyde
Purity
>98.0%(GC)
Packaging
200mg
Price
$73
Updated
2025/07/31
TCI Chemical
Product number
P2261
Product name
Pyrazole-3-carboxaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$291
Updated
2025/07/31
TRC
Product number
P842540
Product name
1H-​Pyrazole-​3-​carboxaldehyde
Packaging
1g
Price
$65
Updated
2021/12/16
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2H-PYRAZOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Colorless Solid

Uses

1H-?Pyrazole-?3-?carboxaldehyde is an intermediate used to prepare fused pyrrole carboxylic acids as novel, potent D-?amino acid oxidase (DAO) inhibitors. It is also a building block to synthesize α-?substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2?/neu tyrosine kinases.

Synthesis

111573-59-2

3920-50-1

The general procedure for the synthesis of 3-pyrazolecarboxaldehyde from 3-dimethoxymethyl-1H-pyrazole: 2.3 kg of formic acid was added slowly and dropwise to 15.5 kg of an aqueous solution containing 13.8 kg of 3-dimethoxymethyl-1H-pyrazole at 0-15 °C. Subsequently, the reaction mixture was magnetically stirred at 25 °C for 12 h. A light yellow solid was obtained upon completion of the reaction. The precipitate was separated by filtration and the filter cake was washed with 10 L of water to give 643 g of the final yellow solid product 3-pyrazolecarboxaldehyde.

References

[1] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5890 - 5893
[2] Chinese Journal of Catalysis, 2016, vol. 37, # 9, p. 1446 - 1450
[3] European Journal of Medicinal Chemistry, 1993, vol. 28, # 2, p. 129 - 140
[4] Patent: CN107235982, 2017, A. Location in patent: Paragraph 0008

2H-PYRAZOLE-3-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-PYRAZOLE-3-CARBALDEHYDE Suppliers

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View Lastest Price from 2H-PYRAZOLE-3-CARBALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2H-PYRAZOLE-3-CARBALDEHYDE 3920-50-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-15
Jiangsu Magic Biotechnology Co., Ltd
Product
2H-PYRAZOLE-3-CARBALDEHYDE 3920-50-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-05-19
Career Henan Chemical Co
Product
2H-PYRAZOLE-3-CARBALDEHYDE 3920-50-1
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-19

3920-50-1, 2H-PYRAZOLE-3-CARBALDEHYDERelated Search:

4-Nitropyrazole-3-carboxylic acid 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOLE-5-CARBONYL CHLORIDE 5-Methyl-1H-pyrazole-3-carboxylic acid 1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBONYL CHLORIDE Pyrazofurin Ethyl 3-methyl-1H-pyrazole-5-carboxylate ETHYL 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLATE 1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE 3,5-PYRAZOLEDICARBOXYLIC ACID 3-(TERT-BUTYL)-1-METHYL-1H-PYRAZOLE-5-CARBONYL CHLORIDE 5-Pyrazolecarboxylic acid 5-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID HYDRAZIDE 5-Methyl-1H-pyrazole-4-carbaldehyde 1-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE 3-CYCLOPROPYL-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 1,5-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE

  • PYRAZOLE-3-CARBALDEHYDE
  • RARECHEM AM LA 0023
  • 3-formylpyrazole
  • 1H-PYRAZOLE-5-CARBALDEHYDE
  • 1H-PYRAZOLE-3-CARBXALDEHYDE
  • 1H-PYRAZOLE-3-CARBALDEHYDE
  • 2H-PYRAZOLE-3-CARBALDEHYDE
  • 2H-PYRAZOLE-3-CARBOXALDEHYDE
  • Pyrazole-3-carboxaldehyde
  • Pyrazol-3-carbaldehyde
  • 1H-Pyrazole-3-carboxaldehyde
  • 3-Pyrazolecarboxaldehyde
  • 1H-Pyrazol-5-carbaldehyde
  • 3-Formyl-1H-pyrazole
  • 1H-Pyrazole-3-carbaldehyde, dimer
  • 1H-Pyrazole-5-carboxaldehyde 97%
  • Pyrazole-3-carboxaldehyde &gt
  • 1H-PYRAZOLE-3-OARBALDEHYDE
  • Pyrazole-3-carboxaldehyde (8CI)
  • 1H pyrazole-3-formaldehyde
  • PYRAZOLE-3-ALDEHYDE
  • DKFELEX0322
  • 1H-Pyrazole-5-carbaldehyde, 97%
  • 3920-50-1