2H-PYRAZOLE-3-CARBALDEHYDE
- Product Name
- 2H-PYRAZOLE-3-CARBALDEHYDE
- CAS No.
- 3920-50-1
- Chemical Name
- 2H-PYRAZOLE-3-CARBALDEHYDE
- Synonyms
- 1H-PYRAZOLE-3-CARBALDEHYDE;1H-PYRAZOLE-5-CARBALDEHYDE;Pyrazole-3-carboxaldehyde;DKFELEX0322;3-formylpyrazole;RARECHEM AM LA 0023;PYRAZOLE-3-ALDEHYDE;3-Formyl-1H-pyrazole;Pyrazol-3-carbaldehyde;PYRAZOLE-3-CARBALDEHYDE
- CBNumber
- CB4670896
- Molecular Formula
- C4H4N2O
- Formula Weight
- 96.09
- MOL File
- 3920-50-1.mol
2H-PYRAZOLE-3-CARBALDEHYDE Property
- Melting point:
- 149.0 to 153.0 °C
- Boiling point:
- 300.0±13.0 °C(Predicted)
- Density
- 1.323
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 11.20±0.10(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C4H4N2O/c7-3-4-1-2-5-6-4/h1-3H,(H,5,6)
- InChIKey
- ICFGFAUMBISMLR-UHFFFAOYSA-N
- SMILES
- N1C=CC(C=O)=N1
- CAS DataBase Reference
- 3920-50-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CDS009918
- Product name
- 1<I>H</I>-Pyrazole-3-carbaldehyde
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 50 mg
- Price
- $107
- Updated
- 2025/07/31
- Product number
- CDS009918
- Product name
- 1H-Pyrazole-3-carbaldehyde
- Purity
- AldrichCPR
- Packaging
- 50mg
- Price
- $104
- Updated
- 2024/03/01
- Product number
- P2261
- Product name
- Pyrazole-3-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $73
- Updated
- 2025/07/31
- Product number
- P2261
- Product name
- Pyrazole-3-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $291
- Updated
- 2025/07/31
- Product number
- P842540
- Product name
- 1H-Pyrazole-3-carboxaldehyde
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
2H-PYRAZOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Colorless Solid
Uses
1H-?Pyrazole-?3-?carboxaldehyde is an intermediate used to prepare fused pyrrole carboxylic acids as novel, potent D-?amino acid oxidase (DAO) inhibitors. It is also a building block to synthesize α-?substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2?/neu tyrosine kinases.
Synthesis
111573-59-2
3920-50-1
The general procedure for the synthesis of 3-pyrazolecarboxaldehyde from 3-dimethoxymethyl-1H-pyrazole: 2.3 kg of formic acid was added slowly and dropwise to 15.5 kg of an aqueous solution containing 13.8 kg of 3-dimethoxymethyl-1H-pyrazole at 0-15 °C. Subsequently, the reaction mixture was magnetically stirred at 25 °C for 12 h. A light yellow solid was obtained upon completion of the reaction. The precipitate was separated by filtration and the filter cake was washed with 10 L of water to give 643 g of the final yellow solid product 3-pyrazolecarboxaldehyde.
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5890 - 5893
[2] Chinese Journal of Catalysis, 2016, vol. 37, # 9, p. 1446 - 1450
[3] European Journal of Medicinal Chemistry, 1993, vol. 28, # 2, p. 129 - 140
[4] Patent: CN107235982, 2017, A. Location in patent: Paragraph 0008
2H-PYRAZOLE-3-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
2H-PYRAZOLE-3-CARBALDEHYDE Suppliers
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- hombrecher@porphyrin-systems.de
- Country
- Germany
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- 444
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- 50
- Tel
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- sales@chemos-group.com
- Country
- Germany
- ProdList
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- Tel
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- Fax
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- sales@rarechem.de
- Country
- Germany
- ProdList
- 6297
- Advantage
- 38
View Lastest Price from 2H-PYRAZOLE-3-CARBALDEHYDE manufacturers
- Product
- 2H-PYRAZOLE-3-CARBALDEHYDE 3920-50-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-15
- Product
- 2H-PYRAZOLE-3-CARBALDEHYDE 3920-50-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-05-19
- Product
- 2H-PYRAZOLE-3-CARBALDEHYDE 3920-50-1
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-19