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κ-Carrageenan

Uses
Product Name
κ-Carrageenan
CAS No.
11114-20-8
Chemical Name
κ-Carrageenan
Synonyms
KAPPA-CARRAGEENAN;IRISH MOSS;κ-carrageenan;kappa-carrageen;IRISH MOSS TYPE III;GELATIN, VEGETABLE TYPE III;CARRAGEENAN;K-Carrageen;Carragreenan;K-CARRAGEENAN
CBNumber
CB4678847
Molecular Formula
C24H36O25S2-2
Formula Weight
788.65764
MOL File
11114-20-8.mol
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κ-Carrageenan Property

solubility 
H2O: 5 mg/mL hot, soluble
form 
Solid
color 
White to almost white to yellow to brownish
biological source
plant
Water Solubility 
H2O: soluble 5mg/mL (hot)
Merck 
14,1864
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Safety

WGK Germany 
2
RTECS 
FI0704000
F 
3
HS Code 
13023990
Toxicity
rabbit,LDLo,intravenous,3mg/kg (3mg/kg),BLOOD: CHANGE IN CLOTTING FACTORS,Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 647, 1965.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
22048
Product name
κ-Carrageenan
Purity
sulfated plant polysaccharide
Packaging
25g
Price
$55
Updated
2025/07/31
Sigma-Aldrich
Product number
22048
Product name
κ-Carrageenan
Purity
sulfated plant polysaccharide
Packaging
100g
Price
$155
Updated
2025/07/31
TCI Chemical
Product number
C1804
Product name
kappa-Carrageenan
Packaging
25g
Price
$49
Updated
2025/07/31
TCI Chemical
Product number
C1804
Product name
kappa-Carrageenan
Packaging
500g
Price
$336
Updated
2025/07/31
TRC
Product number
C184395
Product name
κ-​Carrageenan
Packaging
500mg
Price
$60
Updated
2021/12/16
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κ-Carrageenan Chemical Properties,Usage,Production

Uses

κ-​Carrageenan is a sulfated linear polysaccharide of D-​galactose and 3,​6-​anhydro-​D-​galactose extracted from certain red seaweeds of the Rhodophyceae class. κ-​Carrageenan is used in the food industry as thickening, gelling and protein-​suspending agents, and by the pharmaceutical industry in pills and tablets.

Chemical Properties

sulfate content 20-36%, forms gels powder

Uses

The carrageenans are sulphate gums found in members of the Rhodophyceae. They consist of mixtures of polysaccharides which are mainly composed of D-galactose units linked 1~3 and 1~4. A high proportion ofthe units are substituted with sulphate half-ester groups. The carrageenans are useful stabilisers in foods.

Uses

κ-?Carrageenan is a sulfated linear polysaccharide of D-?galactose and 3,?6-?anhydro-?D-?galactose extracted from certain red seaweeds of the Rhodophyceae class. κ-?Carrageenan is used in the food industry as thickening, gelling and protein-?suspending agents, and by the pharmaceutical industry in pills and tablets.

Definition

A naturally occurringpolysaccharide isolated from redalgae. The polymer is composed of dgalactoseunits, many of which aresulphated. K-carrageenan is a gellingagent with uses similar to those ofagar.

in vivo

κ-Carrageenan can be used in animal modeling to create paw edema, colitis, and thrombosis models. κ-Carrageenan has oral activity; after oral administration, its concentration in BALB/c mice peaks at 3 hours, with an average residence time of 36.6 hours and a clearance rate of 0.1 L/h/kg. Most of the κ-Carrageenan is excreted via feces, while 9.2% is excreted through urine, indicating rapid absorption, slow elimination, and prolonged retention in the body. Additionally, κ-Carrageenan accumulates in the liver and kidneys. After 14 days of oral administration of κ-Carrageenan, hepatocyte necrosis, renal tubular vacuolation, and incomplete colonic epithelial cells are observed. Four hours after intraperitoneal injection of κ-Carrageenan, minor infarcts and erythema appear at the tips of rat tails, with infarct length increasing in a time-dependent manner and stabilizing 24 hours post-injection. Twenty-four hours is determined as the time point for successful establishment of the thrombosis model[4][5][6][7][8][9].

Induction of paw edema[5][6]
Background
κ-Carrageenan induces paw edema by promoting the release of pro-inflammatory factors, leading to localized inflammation.
Specific Modeling Methods
Rat: Wistar ? male ? 80-110 days old ? 240-285 g
Administration: 0.1 mL ? sc ? single dose
Note
κ-Carrageenan is suspended in 0.5% Ringer's solution at a concentration of 1%.
Modeling Indicators
Phenotypic observation: Increased foot volume between the ankle joint and the tibiotarsal joint.
Molecular changes: Neutrophil migration to the foot area of rats injected with κ-carrageenan, along with elevated expression levels of pro-inflammatory factors such as bradykinin, histamine, tachykinins, complement, and reactive oxygen species.
Correlated Product(s): /
Opposite Product(s): /

Induction of colitis[7][8]
Background
κ-Carrageenan induces the expression of pro-inflammatory factors by promoting interactions between intestinal epithelial cells and immune cells (macrophage-like THP-1 cells), thereby disrupting the integrity and function of the intestinal epithelial cells. κ-Carrageenan can also enhance the induction of colitis in mice by TNBS through the activation of the TLR4-NF-κB and MAPK/ERK1/2 pathways.
Specific Modeling Methods
Mice: C57BL/6J ? male and female ? 20-25 g ? 6-week-old
Administration: 1.7, 8.3, 41.7 mg/kg ? po ? single dose
Note
κ-Carrageenan is dissolved in physiological saline.
Modeling Indicators
Phenotypic observation: Weight loss in mice, slight shortening and thickening of the distal colon, with colonic edema and hemorrhage. Damage to the surface of epithelial mucosal cells and disintegration of microvilli.
Molecular changes: Significant upregulation of IL-2, TNF-α, and IL-6 expression, with a notable decrease in IL-10 expression. The enzymatic activity of SOD and GSH-px in the colonic mucosa is reduced, while the expression of TLR4, NF-κB, p-ERK, p-JNK, p-Jun, IL-8, and MDA is upregulated.
Correlated Product(s): TNBS (2,4,6-Trinitrobenzene Sulfonic Acid)
Opposite Product(s): /

Induction of thrombosis[9]
Background
κ-Carrageenan induces thrombosis by causing localized vascular inflammation and endothelial cell damage through the release of inflammatory factors.
Specific Modeling Methods
Rat: Wistar ? male ? 150-160 g ? 7-week-old
Administration: 20 mg/kg ? ip ? single dose
Note
κ-Carrageenan is dissolved in physiological saline.
Modeling Indicators
Phenotypic observation: Swelling, redness, and thrombosis in the tails of rats.
Coagulation parameter changes: In the tails of rats with thrombus formation, prothrombin time (PT) and fibrinogen (FIB) significantly increased, while thrombin time (TT) significantly decreased, as determined by classical coagulation testing methods.
Correlated Product(s): /
Opposite Product(s): Aspirin Eugenol Ester

Animal Model:Male and female NIH (s) mice[2]
Dosage:1.7?mg/kg, LOW; 8.3?mg/kg, MED; or 41.7?mg/kg, HIG
Administration:Orally administered for 1 week prior to C. freundii DBS100 treatment
Result:Enhanced the C. freundii DBS100-dependent induction of TLR4 and NF-κB in the intestinal mucosa of infected mice.

κ-Carrageenan Preparation Products And Raw materials

Raw materials

Preparation Products

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κ-Carrageenan Suppliers

Americas 1 China 278 Europe 2 France 1 Germany 1 India 5 Japan 3 Switzerland 2 United Kingdom 3 United States 14 Global 310
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
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View Lastest Price from κ-Carrageenan manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
κ-Carrageenan 11114-20-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-29
Hebei Chuanghai Biotechnology Co., Ltd
Product
Carrageenan 11114-20-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
κ-Carrageenan 11114-20-8
Price
US $99.00-66.00/kg
Min. Order
0.001kg
Purity
99%
Supply Ability
5000
Release date
2024-08-09

11114-20-8, κ-CarrageenanRelated Search:

Ammonium sulfate Aluminum sulfate Barium sulfate Dimethyl sulfate Magnesium sulfate heptahydrate Sodium sulfate Gellan Gum Guar gum sulfate Seleno-k-carrageenan DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) SALCOMINE METHYL ISOCYANOACETATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) CARRAGEENAN

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