ChemicalBook > CAS DataBase List > 2-Chloromandelic acid

2-Chloromandelic acid

Product Name: 2-Chloromandelic acid
CAS No.: 10421-85-9
Chemical Name: 2-Chloromandelic acid
Synonyms: TIMTEC-BB SBB003705;2-Chloromandelic aci;2-CHLOROMANDELIC ACID;o-chloromandelic acid;Chloromandelic Acid DL-;DL- Chloromandelic acid;DL-2-CHLOROMANDELIC ACID;Orthochloromandelic acid;2-Chloromandelic acid,98%;RS-2-Chloro Mandelic acid
CBNumber: CB4680112
Molecular Formula: C8H7ClO3
Formula Weight: 186.59
MOL File: 10421-85-9.mol

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2-Chloromandelic acid Property

Melting point:: 90-93 °C(lit.)
Boiling point:: 266.91°C (rough estimate)
Density: 1.3245 (rough estimate)
refractive index: 1.5250 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
form: Crystalline Powder
pka: 3.30±0.10(Predicted)
color: White to pale cream
Water Solubility: Very soluble in water.
BRN: 2367070
Stability:: Hygroscopic
InChI: InChI=1S/C8H7ClO3/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7,10H,(H,11,12)
InChIKey: RWOLDZZTBNYTMS-UHFFFAOYSA-N
SMILES: C(C1C=CC=CC=1Cl)(O)C(=O)O
CAS DataBase Reference: 10421-85-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 530182
Product name: 2-Chloromandelic acid
Purity: 98%
Packaging: 5g
Price: $163
Updated: 2025/07/31

TCI Chemical

Product number: C3937
Product name: 2-(2-Chlorophenyl)-2-hydroxyacetic Acid
Purity: min. 98.0 %
Packaging: 25G
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: C3937
Product name: 2-(2-Chlorophenyl)-2-hydroxyacetic Acid
Purity: min. 98.0 %
Packaging: 100G
Price: $180
Updated: 2025/07/31

TRC

Product number: C432673
Product name: 2-Chloromandelic acid
Packaging: 25g
Price: $55
Updated: 2021/12/16

TRC

Product number: C432673
Product name: 2-Chloromandelic acid
Packaging: 50g
Price: $80
Updated: 2021/12/16

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2-Chloromandelic acid Chemical Properties,Usage,Production

Chemical Properties

White to pale cream crystalline powder

Uses

2-Chloromandelic acid, is used as a pharmaceutical intermediate as well as in the medicine industry. It is used as a intermediate of clopidrogrel.

General Description

2-Chloromandelic acid (2-ClMA) is a mandelic acid derivative. A report based on its solid state-NMR, X-ray powder diffraction (XPRD) and Fourier transform infrared spectroscopy (FTIR) data reveals that in solid state 2-ClMA exists as a racemic compound. The study also suggests that the crystals of racemic 2-ClMA belongs the monoclinic space group P21/c. The efficiency of (R)-(+)-N-benzyl-1-phenylethylamine in resolving racemate 2-ClMA has been investigated.

Synthesis

74-90-8

89-98-5

10421-85-9

52923-20-3

First, 150 mL of toluene was added to a flask equipped with a stirrer and an internal thermometer. Under stirring conditions, 0.09 g (0.08 x 10^-3 mol) of the (R,R)-VO salen complex from Example 1 and 21.1 g (0.15 mol) of freshly prepared 2-chlorobenzaldehyde were added sequentially. Subsequently, 10.1 g (0.375 mol) of hydrocyanic acid was added all at once. The resulting dark green homogeneous solution was stirred for 24 h at room temperature in a closed apparatus. The conversion was analyzed by gas chromatography (GC) to be 98% and the enantiomeric excess (ee) value of (S)-2-chloromandelate cyanohydrin was 73%.

References

[1] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[2] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[3] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[4] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[5] Patent: US2004/236129, 2004, A1. Location in patent: Page 4

2-Chloromandelic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloromandelic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloromandelic acid 10421-85-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloromandelic acid 10421-85-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloromandelic acid 10421-85-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

10421-85-9, 2-Chloromandelic acidRelated Search:

2-Chloroaniline Ethyl 2-(Chlorosulfonyl)acetate DL-Malic acid Mandelic acid Folic acid Stearic acid 2-Chlorotoluene 2-(Chloromethyl)benzonitrile (S)-(+)-Mandelic acid Hyaluronic acid Sodium cloxacillin monohydrate 2-Chlorobenzotrifluoride Citric acid α-Lipoic Acid Ascoric Acid 2-Fluoropropiophenone 2-Chlorobenzyl alcohol 2-Fluorobenzaldehyde

TIMTEC-BB SBB003705

o-chloromandelic acid

2-Chloro-alpha-hydroxyphenylaceticacid

Methyl-(2-chlorophenyl) hydroxy carboxylic acid

Chloromandelic Acid DL-

Benzeneacetic acid, 2-chloro-α-hydroxy-

DL-2-CHLOROMANDELIC ACID

2-(2-CHLOROPHENYL)-2-HYDROXYACETIC ACID

2-CHLORO-ALPHA-HYDROXYBENZENEACETIC ACID

2-CHLOROMANDELIC ACID

(2-chlorophenyl)glycolic acid

(n)-2-chloro-à-hydroxyphenylacetic acid

(2-Chlorophenyl)hydroxyacetic acid

2-Chloro-a-hydroxybenzeneacetic acid

2-(2-Chlorophenyl)hydroxyacetic acid

2-Chloro-α-hydroxybenzeneacetic acid

α-Hydroxy-2-chlorobenzeneacetic acid

2-Chloromandelic acid,98%

2-Chloro-α-hydroxyphenylacetic acid

2-Chloromandelic acid ,99%

2-Chloromandelic aci

2-CHLORO MANDELIC ACID 98.5%

Benzeneacetic acid,2-chloro-a-hydroxy-

DL-Chloro phengl glycollic acid

(2R)-2-(2-chlorophenyl)-2-hydroxyacetate

have stock 2-Chloromandelic acid

DL- Chloromandelic acid

RS-2-Chloro Mandelic acid

Orthochloromandelic acid

10421-85-9

ClC6H4CHOHCO2H

Building Blocks

Carbonyl Compounds

Carboxylic Acids

Organic Building Blocks

Carbonyl Compounds

Carboxylic Acids

Miscellaneous

Organic acids