4-Nitrophenylhydrazine hydrochloride

Product Name: 4-Nitrophenylhydrazine hydrochloride
CAS No.: 636-99-7
Chemical Name: 4-Nitrophenylhydrazine hydrochloride
Synonyms: 4-Nitrophenylhydrazi;P-NITROPHENYLHYDRAZINE HCL;4-nitrophenyl hydrazine hcl;NITROPHENYLHYDRAZINE HYDROCHLORIDE;4-NITROPHENYHYDRAZINE HYDROCHLORIDE;(4-nitrophenyl)hydrazinhydrochlorid;P-NITROPHENYLHYDRAZINE HYDROCHLORIDE;4-NITROPHENYLHYDRAZINE HYDROCHLORIDE;Amino-(4-nitrophenyl)azanium chloride;4-Hydrazinonitrobenzene hydrochloride
CBNumber: CB4683522
Molecular Formula: C6H8ClN3O2
Formula Weight: 189.6
MOL File: 636-99-7.mol

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4-Nitrophenylhydrazine hydrochloride Property

Melting point:: 205-207°C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO, Methanol, Water
form: Solid
color: Brown to Reddish Brown
BRN: 3569014
InChI: InChI=1S/C6H7N3O2.ClH/c7-8-5-1-3-6(4-2-5)9(10)11;/h1-4,8H,7H2;1H
InChIKey: ZWWXDCOPVYATOQ-UHFFFAOYSA-N
SMILES: N(C1=CC=C([N+]([O-])=O)C=C1)N.[H]Cl
CAS DataBase Reference: 636-99-7(CAS DataBase Reference)
EPA Substance Registry System: 4-Nitrophenylhydrazine hydrochloride (636-99-7)

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Safety

Hazard Codes: Xi,T
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39-24/25-22
RIDADR: 2811
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: N0233
Product name: 4-Nitrophenylhydrazine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: N0233
Product name: 4-Nitrophenylhydrazine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $158
Updated: 2025/07/31

TRC

Product number: N926093
Product name: 4-Nitrophenylhydrazine Hydrochloride
Packaging: 5g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 021419
Product name: 4-Nitrophenylhydrazine hydrochloride
Purity: 98%
Packaging: 100g
Price: $48
Updated: 2021/12/16

Matrix Scientific

Product number: 021419
Product name: 4-Nitrophenylhydrazine hydrochloride
Purity: 98%
Packaging: 5g
Price: $10
Updated: 2021/12/16

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4-Nitrophenylhydrazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

PINK TO ORANGE CRYSTALLINE POWDER

Uses

4-Nitrophenylhydrazine is a nitro substituted aryl hydrazine with potential anticancer activity.

Synthesis

100-01-6

636-99-7

The general procedure for the synthesis of 4-nitrophenylhydrazine hydrochloride from 4-nitroaniline was as follows: 4-nitroaniline (1.47 g, 10.6 mmol) was dissolved in concentrated hydrochloric acid (2 mL) and the solution was cooled to 0°C. A solution of sodium nitrite (717 mg, 10.4 mmol) dissolved in water (4 mL) was added dropwise to the above reaction mixture under ice bath conditions with continuous stirring for 1 hour. Subsequently, a pre-cooled solution of concentrated hydrochloric acid (2 mL) of stannous chloride (4.7 g, 20.8 mmol) was slowly added to the diazo reaction mixture. The reaction mixture was continued to be stirred at 0°C for 2 hours. Upon completion of the reaction, the resulting yellow-orange precipitate was collected and washed thoroughly with ice-cold water until the filtrate was neutral (pH ≈ 7). Finally, the precipitate was dried under vacuum conditions overnight to afford the target product 4-nitrophenylhydrazine hydrochloride (640 mg, 4.18 mmol, 39% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 4.49 (s, 2H), 6.78 (d, J=8.78 Hz, 2H), 7.98 (d, J=9.29 Hz, 2H), 8.41 (s, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 9, p. 2739 - 2752
[2] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[3] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[4] Journal of Agricultural and Food Chemistry, 2014, vol. 62, # 2, p. 381 - 390
[5] Oriental Journal of Chemistry, 2017, vol. 33, # 2, p. 1041 - 1044

4-Nitrophenylhydrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Nitrophenylhydrazine hydrochloride Suppliers

Americas 1 Austria 1 Canada 1 China 221 Europe 3 Germany 2 India 10 Japan 4 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 13 United States 35 Global 295

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View Lastest Price from 4-Nitrophenylhydrazine hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Nitrophenylhydrazine hydrochloride 636-99-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

Henan Fengda Chemical Co., Ltd

Product: 4-Nitrophenylhydrazine hydrochloride 636-99-7
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Nitrophenylhydrazine Hydrochloride 636-99-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-07

636-99-7, 4-Nitrophenylhydrazine hydrochloride Related Search:

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4-Nitrophenylhydrazine hydrochloride ISO 9001：2015 REACH

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636-99-7

C6H8N3O2HCI

C6H8N3O2Cl

O2NC6H4NHNH2HCl

C6H7N3O2HCl

Phenylhydrazine

Amines

blocks

Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes