ChemicalBook > CAS DataBase List > N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Product Name
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine
CAS No.
5294-61-1
Chemical Name
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine
Synonyms
RZ-2;RS 94287;CVT-2738;EC 610-916-8;UNII-NYS3I6283H;RANOLAZINE MOMOAMIDE;Ranolazine impurity G;1-piperazin acetylamine;CVT-2738, 10 mM in DMSO;Ranolazine Related CoMpound C
CBNumber
CB4686477
Molecular Formula
C14H21N3O
Formula Weight
247.34
MOL File
5294-61-1.mol
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N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Property

Melting point:
110-112°C
Boiling point:
411.2±45.0 °C(Predicted)
Density 
1.101±0.06 g/cm3(Predicted)
vapor pressure 
0-0Pa at 20-25℃
storage temp. 
-20°C Freezer
solubility 
DMSO, Methanol
pka
14.62±0.70(Predicted)
form 
Crystalline Powder
color 
Light gray
InChIKey
NJKRFQIWDJSYOK-UHFFFAOYSA-N
LogP
0.74 at 20℃ and pH12
CAS DataBase Reference
5294-61-1(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4319
Product name
N-(2,6-Dimethylphenyl)-1-piperazineacetamide
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$34
Updated
2022/04/27
TCI Chemical
Product number
D4319
Product name
N-(2,6-Dimethylphenyl)-1-piperazineacetamide
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$90
Updated
2021/12/16
TRC
Product number
D476950
Product name
N-(2,6-Dimethylphenyl)-1-piperazineacetamide
Packaging
1g
Price
$110
Updated
2021/12/16
AK Scientific
Product number
J54062
Product name
N-(2,6-Diphenylmethyl)-1-piperazineacetylamine
Packaging
5g
Price
$28
Updated
2021/12/16
Chem-Impex
Product number
43394
Product name
N-(2,6-Dimethylphenyl)-1-piperazineacetamide,≥98%(GC)
Purity
≥98%(GC)
Packaging
5G
Price
$28.89
Updated
2021/12/16
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N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Chemical Properties,Usage,Production

Chemical Properties

Pale Beige Solid

Uses

A metabolite of Ranolazine.

Synthesis

142-63-2

1131-01-7

5294-61-1

The general procedure for the synthesis of N-(2,6-dimethylphenyl)-1-piperazine acetamide from piperazine hexahydrate and 2,6-dimethylchloroacetanilide was as follows: 58.3 g (0.3 mol) of piperazine hexahydrate was dissolved in 230 ml of ethanol, followed by the addition of 50.0 g (0.25 mol) of 2-chloro-N-(2,6-dimethylphenyl)acetamide. The reaction mixture was heated under reflux conditions for 3 hours until the reaction was complete. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure followed by addition of 80 ml of water. The mixture was extracted with water and dichloromethane, and after separation of the organic layer, it was concentrated under vacuum at 60 °C to give 39.4 g of N-(2,6-dimethylphenyl)-1-piperazine acetamide in 63% yield. The product was characterized by 1HNMR (CDCl3): δ 2.23-2.27 (s, 6H), 2.67 (s, 4H), 2.96-2.98 (t, 4H), 3.19-3.21 (s, 2H), 7.08-7.26 (m, 3H), 8.69 (s, 1H).

References

[1] Patent: US2013/90475, 2013, A1. Location in patent: Paragraph 0029; 0030

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Suppliers

Americas 1 Canada 1 China 209 Europe 1 Germany 2 India 47 Italy 1 Japan 2 Ukraine 2 United Kingdom 7 United States 25 Global 298
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from N-(2,6-Diphenylmethyl)-1-piperazine acetylamine manufacturers

Baoji Guokang Healthchem co.,ltd
Product
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1
Price
US $125.00/KG
Min. Order
1Kg/Bag
Purity
99
Supply Ability
10T
Release date
2021-06-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

5294-61-1, N-(2,6-Diphenylmethyl)-1-piperazine acetylamineRelated Search:

Thioacetamide Bensulfuron methyl CARBONYL SULFIDE PYRAZOPHOS Acetamide Acetaminophen Piperazine Kresoxim-methyl Methyl acrylate Chlorodimethylphenylsilane Methylparaben 2',6'-Pipecoloxylidide N-(2,6-Dimethylphenyl)-2-picolinamide N-(2,4,6-Trichlorophenyl)maleimide N,N-Dimethylacetamide Methyl Parathion-methyl Methyl bromide

  • N-(2,6-dimethylphenyl)-2-piperazin-1-yl-ethanamide
  • 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-
  • Ranolazine impurity G
  • N-(2,6-Dimethylphenyl)-1-Piper
  • N-(2,6-Dimethylphenyl)-2- 1-Piperazinyl)Acetamide
  • 1-Piperazineaceto-2',6'-xylidide
  • 4-[(2,6-Dimethylphenyl)aminocarbonylmethyl]piperazine
  • N-(2,6-Dimethylphenyl)-2-piperazinylacetamide
  • RS 94287
  • N-(2,6-DIMETHYLPHENYL)-1-PIPERAZIN-ACETAMIDE
  • N-(2,6-DIMETHYLPHENYL)-1-PIPERAZINEACETAMIDE
  • N-(2,6-DIMETHYL-PHENYL)-2-PIPERAZIN-1-YL-ACETAMIDE
  • N-(2,6-Diphenylmethyl)-1-piperazine acetylamine
  • 1-[N-(2,6-dimethylphenyl)carbamoylmethyl]piperazine
  • RZ-2
  • 1-(2,6-Dimethylphenyl)-1-Piperazineacetamide
  • N-(2,6-DiphenylMethyl)-1-piperazine
  • 1-[N-2,6-DIMETHYLPHENYLCARBOMYL METHYL]PIPERAZINE
  • Ranolazine Related CoMpound C
  • N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 1-[(2,6-Dimethylanilino)carbonyl-methyl]-piperazine
  • Ranolazine Related Compound C (50 mg) (N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide)
  • 1-[(2,6-DIMETHYLANILINO)CARBONYL-METHYL]-PIPERAZINE
  • N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide 97%
  • Ranolazine Related Compound 1
  • N-(2,6-Dimethylphenyl)-1-piperazineacetamide&gt
  • N-(2,6-Dimethylphenyl)-2-(piperazin
  • 1-piperazin acetylamine
  • CVT-2738
  • N-(2,6-Dimethoxyphenyl)-2-piperazin-1-yl)Acetamide
  • N-(2,6-Dimethylphenyl)-1-piperazineacetamideQ: What is N-(2,6-Dimethylphenyl)-1-piperazineacetamide Q: What is the CAS Number of N-(2,6-Dimethylphenyl)-1-piperazineacetamide Q: What is the storage condition of N-(2,6-Dimethylphenyl)-1-piperazineacetamide Q: What are the applications of N-(2,6-Dimethylphenyl)-1-piperazineacetamide
  • Ranolazine Related Compound C (N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide) (1598777)
  • EC 610-916-8
  • UNII-NYS3I6283H
  • Ranolazine USP Related Compound C
  • RANOLAZINE MOMOAMIDE
  • N-(2,6-dimethyl phenyl)-2-piperazin-1-yl acetam R&D Scale
  • Ranolazine Related Compound C 1-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine
  • N- (2Z6-Dimethyl phenyl )-2-(Piperazin-l-YI) Acetamide
  • CVT-2738, 10 mM in DMSO
  • N-(2,6-Dimethylphenyl)-1-piperazinecarboxamide
  • 5294-61-1
  • 5249-61-1
  • C14H21N3O
  • Ranolazine
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • INTERMEDIATESOFRANOLAZINE