4-Propoxyphenol

4-Propoxyphenol Property

Melting point:

54-56 °C(lit.)

Boiling point:

234.66°C (rough estimate)

Density 

1.0505 (rough estimate)

refractive index 

1.4910 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

10.34±0.15(Predicted)

color 

Light Brown

CAS DataBase Reference

18979-50-5(CAS DataBase Reference)

NIST Chemistry Reference

4-Propoxyphenol(18979-50-5)

EPA Substance Registry System

Phenol, 4-propoxy- (18979-50-5)

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

TSCA 

Yes

HS Code 

29071990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

4-Propoxyphenol Chemical Properties,Usage,Production

Chemical Properties

BEIGE CRYSTALLINE POWDER

Uses

Intermediates of Liquid Crystals

Synthesis

To a mixture of p-benzoquinone (1 mmol) and n-propanol (4.0 mL) was added Amberlyst-15 (40 mg), and the mixture was reacted at reflux for 4-7 hours at 100 °C until the p-benzoquinone was fully reacted (monitored by TLC). After completion of the reaction, the reaction mixture was filtered and the residue was washed with ethyl acetate (25 mL). The washed solution was combined with the filtrate, water (25 mL) was added to the combined solution, and the aqueous layer was extracted with ethyl acetate (2 x 10 mL). The ethyl acetate extracts were combined and dried with anhydrous Na2SO4. The dried extracts were concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography with the eluent being a mixed solvent of ethyl acetate-petroleum ether. The purified product was further crystallized using CH2Cl2-petroleum ether mixed solvent. All the synthesized 4-propoxyphenols were characterized by physical properties, elemental analysis and spectral data.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 1, p. 86 - 89