4-N-PROPYLANISOLE Property

Melting point:

45-46 °C

Boiling point:

215 °C(lit.)

Density 

0.941 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.504(lit.)

FEMA 

2930 | P-PROPYLANISOLE

Flash point:

194 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Very slightly soluble in water, soluble in alcohol and oils

color 

Colorless liquid

Odor

at 10.00 % in dipropylene glycol. sweet anise licorice sassafrass fennel

Odor Type

anisic

JECFA Number

1244

LogP

3.66

CAS DataBase Reference

104-45-0(CAS DataBase Reference)

EPA Substance Registry System

p-Propylanisole (104-45-0)

Safety

Hazard Codes 

N

Risk Statements 

51/53

Safety Statements 

61

RIDADR 

UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)

WGK Germany 

2

RTECS 

BZ9450000

Toxicity

The acute oral LD₅₀ value was reported as 4.4 g/kg (3.38-5.72 g/kg) in the rat and as 7.30 g/kg (5.93-9.00 g/kg) in the mouse (Jenner, Hagan, Taylor, Cook & Fitzhugh, 1964). The acute dermal LD₅₀ value in rabbits was reported as > 5 g/kg (Levenstein, 1974).

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

4-N-PROPYLANISOLE Chemical Properties,Usage,Production

Chemical Properties

p-Propyl anisole has a characteristic anise-type odor with a sassafras undertone.

Occurrence

Reported found in katsuobishi (dried bonito).

Uses

The malerial is more stable in soap than Anethole. It finds some application in perfume compositions. particularly in low-cost masking odors for industrial purposes, detergent perfumes, household fragrances, etc. It is used in flavor compositions for Licor-ice, Rootbeer, Birchbeer, Spice blends, Vanilla imitation, Wintcrgreen, etc.

Definition

ChEBI: 1-Methoxy-4-propylbenzene is a member of methoxybenzenes.

Preparation

By partial hydrogenation of anethole in the presence of nickel at 60 to 95°C under pressure or under atmospheric pressure.

Aroma threshold values

Aroma characteristics at 1.0% EtoH: intense, lingering sweet anise, licorice with an herbal fennel nuance. It is reminiscent of black cough drops and root beer.

Taste threshold values

Taste characteristics at 1 to 15 ppm: intense herbal, fennel, sweetness reminiscent of black licorice, sassafras and anise. It has slight, spicy, basil-like nuances.

Synthesis Reference(s)

Tetrahedron Letters, 40, p. 6729, 1999 DOI: 10.1016/S0040-4039(99)01394-5

Safety Profile

Mildly toxic by ingestion. Mutation data reported. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.