1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER

1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER Property

Boiling point:

162.3±23.0 °C(Predicted)

Density 

1.127±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

7.71±0.20(Predicted)

form 

Solid

Appearance

Colorless to light yellow Liquid

Safety

Hazard Codes 

Xn

Risk Statements 

22

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

1-AMINO-CYCLOBUTANECARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

Stage 1: Synthesis of methyl 1-aminocyclobutanecarboxylate Concentrated H2SO4 (10 ml) was slowly added to a methanol solution (30 ml) containing 1-(tert-butoxycarbonylamino)-cyclobutane-1-carboxylic acid (9.29 mmol, 1 eq.) at 0°C. The reaction mixture was refluxed at 0°C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in distilled water and the pH was adjusted to 8-9 with saturated sodium bicarbonate solution, followed by extraction with ethyl acetate (2 x 200 ml). The combined organic phases were washed sequentially with distilled water (2 x 150 ml) and saturated NaCl solution (2 x 50 ml) and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to afford methyl 1-aminocyclobutanecarboxylate as a white solid in 75% yield.

References

[1] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 34