Nalpha-FMOC-L-Glutamine

Product Name: Nalpha-FMOC-L-Glutamine
CAS No.: 71989-20-3
Chemical Name: Nalpha-FMOC-L-Glutamine
Synonyms: FMOC-GLN;NSC334303;FMOC-L-GLN;FMOC-GLN-OH;Fmoc-GIn-OH;Fmoc-Gln-0H;FMOC-L-GLN-OH;FMOC-GLUTAMINE;FMOC-L-GLUTAMINE;Fmoc-Glutamine-OH
CBNumber: CB4714259
Molecular Formula: C20H20N2O5
Formula Weight: 368.38
MOL File: 71989-20-3.mol

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Nalpha-FMOC-L-Glutamine Property

Melting point:: 220 °C (dec.)(lit.)
alpha: -18 º (c=1,DMF)
Boiling point:: 498.73°C (rough estimate)
Density: 1.3116 (rough estimate)
refractive index: -18 ° (C=1, DMF)
storage temp.: 2-8°C
solubility: almost transparency in N,N-DMF
form: powder to crystal
pka: 3.73±0.10(Predicted)
color: White to Almost white
optical activity: [α]20/D 18.5±1.5°, c = 1% in DMF
BRN: 4722773
CAS DataBase Reference: 71989-20-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36/37/39-27-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52205
Product name: Fmoc-Gln-OH
Purity: Novabiochem?
Packaging: 5G
Price: $27.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52205
Product name: Fmoc-Gln-OH
Purity: Novabiochem?
Packaging: 25g
Price: $72.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52205
Product name: Fmoc-Gln-OH
Purity: Novabiochem?
Packaging: 100g
Price: $224
Updated: 2025/07/31

TCI Chemical

Product number: F0308
Product name: Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: F0308
Product name: Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $46
Updated: 2025/07/31

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Nalpha-FMOC-L-Glutamine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

N2-Fmoc-L-glutamine is an N-Fmoc-protected form of L-Glutamine (G597000). L-Glutamine is a non-essential amino acid that is important for cells that proliferate quickly in the body, such as those of the immune system. L-Glutamine is known to be especially important for the gut, as it helps to maintain intestinal structure and function. L-Glutamine also has protective properties against host toxicity of chemotherapy in cancer patients.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

56-85-9

82911-69-1

71989-20-3

To a stirred solution of L-glutamine (1.75 g, 12 mmol) and sodium carbonate (1.27 g, 12 mmol) in 30 mL of water, a solution of 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu, 3.0 g, 8.9 mmol) dissolved in 60 mL of tetrahydrofuran (THF) was slowly added. The reaction mixture was stirred overnight at room temperature. Subsequently, THF was removed by distillation under reduced pressure. the residue was diluted with 100 mL of 1N hydrochloric acid and the precipitated white solid was collected by filtration. The solid was further recrystallized in a mixed aqueous solution of DMF with 0.1 N hydrochloric acid to afford the target product (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-amino-5-oxopentanoic acid as a white powder (2.76 g, 84% yield). The product was characterized by 1H-NMR (90 MHz, DMSO-d6) with chemical shifts of 12.47 (1H, s), 7.89-7.20 (10H, m), 6.68 (1H, s, br), 4.22-3.90 (4H, m), and 2.25-1.86 (4H, m).

References

[1] Journal of Peptide Science, 2017, vol. 23, # 3, p. 202 - 214
[2] Patent: US2006/161007, 2006, A1. Location in patent: Page/Page column 12
[3] Synthetic Communications, 2009, vol. 39, # 11, p. 2022 - 2031

Nalpha-FMOC-L-Glutamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Nalpha-FMOC-L-Glutamine Suppliers

Americas 1 Belgium 1 China 278 Europe 5 France 3 Germany 6 Hungary 1 India 26 Italy 2 Japan 8 Switzerland 6 United Kingdom 12 United States 56 Global 405

J & K SCIENTIFIC LTD.

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View Lastest Price from Nalpha-FMOC-L-Glutamine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Gln-OH 71989-20-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-07

Henan Bao Enluo International TradeCo.，LTD

Product: Nalpha-FMOC-L-Glutamine 71989-20-3
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-05-18

Sichuan Jiaying Lai Technology Co.,LTD

Product: Fmoc-L-Gln-OH 71989-20-3
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-23

71989-20-3, Nalpha-FMOC-L-GlutamineRelated Search:

Transglutaminase 9-Fluorenylmethyl chloroformate Boc-D-Glutamine L-Alanyl-L-Glutamine L-Glutamine Glycyl-L-glutamine monohydrate Fmoc-Aib-OH Fmoc-OSu Fmoc-L-aspartic acid Fmoc-D-Asn(Trt)-OH FMOC-5-AMINOPENTANOIC ACID Fmoc-Gly-OH Fmoc-D-phenylalanine Fmoc-Met-OH FMOC-L-Methionine Fmoc-D-leucine Fmoc-D-tryptophan Fmoc-D-Tyr(tBu)-OH

FMOC-L-GLUTAMINE

FMOC-L-GLN-OH

FMOC-L-GLN

FMOC-GLN-OH

FMOC-GLN

FMOC-GLUTAMINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMINE

NALPHA-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-GLUTAMINE

N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-GLUTAMINE

N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMINE

N-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMINE

N-ALPHA-FMOC-L-GLUTAMINE

N-ALPHA-FMOC-L-GLN

9-FLUORENYLMETHOXYCARBONYL-L-GLUTAMINE

n(alpha)-fluorenylmethoxycarbonylglutamine

NSC334303

L-GLUTAMINE-N-FMOC (13C5,15N2)

(9H-Fluoren-9-yl)MethOxy]Carbonyl Gln-OH

Fmoc-L-glutamine≥ 99% (HPLC, Chiral purity)

(2S)-4-carbamoyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid

N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine

N-α-Fmoc-L-glutamine

NA-FMOC-L-GLUTAMINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-&

L-Glutamine-UL-13C5,UL-15N2-N-FMOC

FMOC-L-GLUTAMINE extrapure

5-Amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid

N2-(9H-Fluorene-9-ylmethoxycarbonyl)-L-glutamine

Nα-(9H-Fluorene-9-ylmethoxycarbonyl)-L-glutamine

Nalpha-FMOC-L-Glutamine,98%

N-(9-Fluorenylmethyloxycarbonyl)-L-glutamine ,98%

Nalpha-FMOC-L-Glutam

Fmoc-Glutamine-OH

L-GLUTAMINE-N-FMOC

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-amino-5-oxopentanoic acid

Nalpha-Fmoc-L-glutamine Fmoc-Gln-OH

4-Carbamoyl-2-([(9H-fluoren-9-ylmethoxy)carbonyl]amino)butanoic acid

5-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid

5-amino-2-[(9H-fluoren-9-ylmethoxy-oxomethyl)amino]-5-oxopentanoic acid

Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine&gt

L-Glutamine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Nalpha-FMOC-L-Glutamine USP/EP/BP

Fmoc-L-glutamine, puriss, 99%

TIANFU-CHEM Nalpha-FMOC-L-Glutamine

(2S)-5-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid

Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine

Fmoc-GIn-OH

Fmoc-Gln-0H

Na-(9-Fluorenylmethoxycarbonyl)-L-glutamine

Nα-Fmoc-L-glutamine

71989-20-3

7198-20-3

71686-20-3

C20H20N2O5

H2NCOCH22CHNHFMOCCOOH

C20H19N2O5

Glutamine