ChemicalBook > CAS DataBase List > Dihydrofuran-3(2H)-one

Dihydrofuran-3(2H)-one

Product Name: Dihydrofuran-3(2H)-one
CAS No.: 22929-52-8
Chemical Name: Dihydrofuran-3(2H)-one
Synonyms: Oxolan-3-one;tetrahydrofuran-3-one;3-OXOTETRAHYDROFURAN;DIHYDRO-FURAN-3-ONE;Dihyro-3(2H)-Furanone;Dihydrofuran-3(2H)-one;DIHYDRO-3(2H)-FURANONE;3(2H)-FURANONE, DIHYDRO-;Triton X-100 / Octoxinol;Tetrahydrofuran-3-one,95%
CBNumber: CB4723598
Molecular Formula: C4H6O2
Formula Weight: 86.09
MOL File: 22929-52-8.mol

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Dihydrofuran-3(2H)-one Property

Boiling point:: 68°C/60mmHg(lit.)
Density: 1.1124 g/cm3(Temp: 420 °C)
refractive index: 1.4360-1.4400
Flash point:: 56°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Liquid
color: Colorless to Yellow
Stability:: Volatile
InChI: InChI=1S/C4H6O2/c5-4-1-2-6-3-4/h1-3H2
InChIKey: JLPJFSCQKHRSQR-UHFFFAOYSA-N
SMILES: O1CCC(=O)C1

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Safety

Hazard Codes: Xn
Risk Statements: 11-19-36/37/38-22
Safety Statements: 16-26-36/37/39-23
RIDADR: 1993
HazardClass: 3
PackingGroup: III
HS Code: 2932190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2971
Product name: Tetrahydrofuran-3-one
Purity: >98.0%(GC)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: T2971
Product name: Tetrahydrofuran-3-one
Purity: >98.0%(GC)
Packaging: 5g
Price: $134
Updated: 2025/07/31

TRC

Product number: O870480
Product name: 3-Oxotetrahydrofuran
Packaging: 5g
Price: $70
Updated: 2021/12/16

TRC

Product number: O870480
Product name: 3-Oxotetrahydrofuran
Packaging: 1g
Price: $50
Updated: 2021/12/16

TRC

Product number: O870480
Product name: 3-Oxotetrahydrofuran
Packaging: 500mg
Price: $40
Updated: 2021/12/16

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Dihydrofuran-3(2H)-one Chemical Properties,Usage,Production

Chemical Properties

Colorless transparent liquid

Uses

3-Oxotetrahydrofuran is a reagent in the preperation of dihydropteridinone which are orally active Polo-like kinase-2 (Plk-2) inhibitors.

Definition

ChEBI: Oxolan-3-one is an oxalane substituted by an oxo group at position 3. It is functionally related to an oxolane.

Synthesis

453-20-3

22929-52-8

The general procedure for the synthesis of dihydro-3(2H)-furanone from 3-hydroxytetrahydrofuran was as follows: 3-hydroxytetrahydrofuran (3-OH-THF, 60.6 g, 0.68 mol, 1.0 eq.) was added to a 1 L three-necked flask, followed by the addition of dichloromethane (DCM, 620 mL) and 2,2,6,6-tetramethylpiperidin-1-oxyl radical (TEMPO 1.08 g, 0.0069 mol, 0.01 equiv). The reaction system was cooled to -5°C. Trichloroisocyanuric acid (TCCA, 159.6 g, 0.68 mol, 1.0 eq.) was added in batches while maintaining the temperature at -5°C to 0°C. The reaction mixture was gradually warmed up to room temperature and the reaction progress was monitored by gas chromatography-mass spectrometry (GC-MS). The reaction was completed after about 1 h. The product yield was 95% by GC area percentage analysis.

References

[1] Patent: WO2014/139080, 2014, A1. Location in patent: Page/Page column 8; 9
[2] Patent: WO2014/140017, 2014, A1. Location in patent: Page/Page column 7
[3] Patent: US2014/275579, 2014, A1. Location in patent: Paragraph 0033
[4] Patent: WO2006/67430, 2006, A1. Location in patent: Page/Page column 50
[5] Patent: WO2018/132905, 2018, A1. Location in patent: Paragraph 00420-00422

Dihydrofuran-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dihydrofuran-3(2H)-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Dihydrofuran-3(2H)-one 22929-52-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Hebei Chuanghai Biotechnology Co., Ltd

Product: Triton X-100 / Octoxinol 22929-52-8
Price: US $1.00/PCS
Min. Order: 1PCS
Purity: 99%
Supply Ability: 10mt
Release date: 2024-10-30

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Dihydro-3(2H)-furanone 22929-52-8
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-04

22929-52-8, Dihydrofuran-3(2H)-oneRelated Search:

2-Methyltetrahydrofuran TETRAHYDRO-3-FURANMETHANOL Tetrahydrofurfuryl bromide Tetrahydrofuran Poly(tetrahydrofuran) 3-METHYLTETRAHYDROFURAN Furan Furazolidone 4-Methoxy-2,5-dimethyl-3(2H)-furanone Furaneol acetate 2-Methyltetrahydrofuran-3-one TETRONIC ACID DEHYDROASCORBIC ACID DIHYDRO-4,4-DIMETHYL-2,3-FURANDIONE D-(-)-PANTOLACTONE gamma-Octanoic lactone 3-CHLORO-2,4(3H,5H)-FURANDIONE 1,2:5,6-DI-O-ISOPROPYLIDENE-ALPHA-D-RIBO-3-HEXULOFURANOSE

3(2H)-FURANONE, DIHYDRO-

3-OXOTETRAHYDROFURAN

DIHYDRO-3(2H)-FURANONE

DIHYDRO-FURAN-3-ONE

Dihyro-3(2H)-Furanone

Oxolan-3-one

Dihydrofuran-3(2H)-one

tetrahydrofuran-3-one

3-Oxo-1,4-epoxybutane, Oxolan-3-one

3-Oxotetrahydrofuran, >95%

Tetrahydrofuran-3-one,95%

Triton X-100 / Octoxinol

TIANFU-CHEM - Dihydrofuran-3(2H)-one

22929-52-8

Heterocycle-other series

Carbonyl Compounds

Heterocycles