ChemicalBook > CAS DataBase List > 4-(4-Methoxyphenyl)butyric acid

4-(4-Methoxyphenyl)butyric acid

Product Name
4-(4-Methoxyphenyl)butyric acid
CAS No.
4521-28-2
Chemical Name
4-(4-Methoxyphenyl)butyric acid
Synonyms
4-(4-METHOXYPHENYL)BUTANOIC ACID;4-(4-Methoxyphenyl)b;4-methoxyphenylbutyricacid;4-Methoxybenzenebutyric acid;4-Methoxybenzenebutanoic acid;4-(4-Methoxyphenyl)butyricaci;4-(p-methoxyphenyl)butyricacid;4-(4-METHOXYPHENYL)BUTYRIC ACID;Benzenebutanoic acid, 4-methoxy-;Allisartan Isoproxil Impurity 22
CBNumber
CB4746722
Molecular Formula
C11H14O3
Formula Weight
194.23
MOL File
4521-28-2.mol
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4-(4-Methoxyphenyl)butyric acid Property

Melting point:
56-59 °C (lit.)
Boiling point:
196 °C / 10mmHg
Density 
1.116±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Slightly soluble in methanol. Insoluble in chloroform.
form 
Powder
pka
4.76±0.10(Predicted)
color 
Cream to slightly yellow
Water Solubility 
994.9g/L(37 ºC)
BRN 
2416568
InChI
InChI=1S/C11H14O3/c1-14-10-7-5-9(6-8-10)3-2-4-11(12)13/h5-8H,2-4H2,1H3,(H,12,13)
InChIKey
LZHMNCJMXQKSBY-UHFFFAOYSA-N
SMILES
C1(CCCC(O)=O)=CC=C(OC)C=C1
LogP
2.33
CAS DataBase Reference
4521-28-2(CAS DataBase Reference)
NIST Chemistry Reference
4-(4-Methoxyphenyl)butyric acid(4521-28-2)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
163384
Product name
4-(4-Methoxyphenyl)butyric acid
Purity
97%
Packaging
5g
Price
$107
Updated
2023/01/07
Sigma-Aldrich
Product number
163384
Product name
4-(4-Methoxyphenyl)butyric acid
Purity
97%
Packaging
25g
Price
$187
Updated
2021/12/16
TCI Chemical
Product number
M2037
Product name
4-(4-Methoxyphenyl)butyric Acid
Purity
>95.0%(GC)
Packaging
5g
Price
$76
Updated
2025/07/31
TCI Chemical
Product number
M2037
Product name
4-(4-Methoxyphenyl)butyric Acid
Purity
>95.0%(GC)
Packaging
25g
Price
$220
Updated
2025/07/31
TRC
Product number
M329568
Product name
4-(4-Methoxyphenyl)butyric acid
Packaging
250mg
Price
$45
Updated
2021/12/16
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4-(4-Methoxyphenyl)butyric acid Chemical Properties,Usage,Production

Chemical Properties

cream to slightly yellow powder

Uses

4-(4-Methoxyphenyl)butyric acid on demethylation with pyridinium hydrochloride affords 4-hydroxyphenylbutyric acid, a key starting material for the synthesis of preclinical candidate LY518674.

Synthesis

3153-44-4

4521-28-2

Step G: 4-(4-methoxyphenyl)-4-oxobutanoic acid (40 g) was suspended in a solvent mixture of acetic acid (100 ml) and tetrahydrofuran (THF, 100 ml). To this suspension, 10% palladium-carbon catalyst (50% wet weight, 4 g) was added, followed by stirring the reaction mixture under hydrogen atmosphere (0.4 MPa) for 9 hours. Upon completion of the reaction, it was filtered through a diatomaceous earth pad to remove the catalyst. Toluene was added to the filtrate and the solvent was subsequently removed by distillation under reduced pressure to afford 4-(4-methoxyphenyl)butanoic acid in quantitative yield. The product was characterized by 1H-NMR (CDCl3): δ 1.89 (m, 2H), 2.32 (t, J=7.3 Hz, 2H), 2.58 (t, J=7.4 Hz, 2H), 3.73 (s, 3H), 6.78-6.82 (m, 2H), 7.03-7.08 (m, 2H), 10.96 (brs, 1H).

References

[1] Patent: EP1726587, 2006, A1. Location in patent: Page/Page column 33
[2] Chemistry of Natural Compounds, 2003, vol. 39, # 4, p. 404 - 406
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998, vol. 37, # 3, p. 281 - 284
[4] Research on Chemical Intermediates, 2017, vol. 43, # 10, p. 5933 - 5942
[5] Journal of Organic Chemistry, 1990, vol. 55, # 11, p. 3537 - 3543

4-(4-Methoxyphenyl)butyric acid Preparation Products And Raw materials

Raw materials

Diethylene glycol Hydrazinium hydroxide solution Potassium hydroxide Anisole Succinic anhydride Aluminum chloride Diethyl ether Ethyl acetate Methanol Nitrobenzene Magnesium sulfate PETROLEUM ETHER Citric acid

Preparation Products

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View Lastest Price from 4-(4-Methoxyphenyl)butyric acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-(4-Methoxyphenyl)butyric acid 4521-28-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000kgs
Release date
2025-05-23
Shaanxi Dideu New Materials Co. Ltd
Product
4-(4-Methoxyphenyl)butyric acid 4521-28-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-05-23
Shaanxi Dideu Medichem Co. Ltd
Product
4-(4-Methoxyphenyl)butyric acid 4521-28-2
Price
US $25.00-11.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-12

4521-28-2, 4-(4-Methoxyphenyl)butyric acidRelated Search:

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