6-Shogaol
- Product Name
- 6-Shogaol
- CAS No.
- 555-66-8
- Chemical Name
- 6-Shogaol
- Synonyms
- SHOGAOL;6-SHOGAOL;6-Shagaol;SHOGAOL, 6-;6-gingerenol;6-Shogaol USP/EP/BP;[6]-Shogaol D5 (Major);TIANFU-CHEM - 6-Shogaol;1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one;1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one
- CBNumber
- CB4748322
- Molecular Formula
- C17H24O3
- Formula Weight
- 276.37
- MOL File
- 555-66-8.mol
6-Shogaol Property
- Boiling point:
- 427.5±35.0 °C(Predicted)
- Density
- 1.0448 g/cm3(Temp: 25 °C)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 10.01±0.20(Predicted)
- color
- Colourless to Light Yellow
- BRN
- 2056098
- InChI
- InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3
- InChIKey
- OQWKEEOHDMUXEO-BQYQJAHWSA-N
- SMILES
- C(C1=CC=C(O)C(OC)=C1)CC(=O)C=CCCCCC
- LogP
- 3.789 (est)
- CAS DataBase Reference
- 555-66-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-shogaol(555-66-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SMB00311
- Product name
- [6]-Shogaol
- Purity
- ≥90% (HPLC)
- Packaging
- 50mg
- Price
- $947
- Updated
- 2024/03/01
- Product number
- 39303
- Product name
- [6]-Shogaol
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $740
- Updated
- 2024/03/01
- Product number
- 11901
- Product name
- 6-Shogaol
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 11901
- Product name
- 6-Shogaol
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 11901
- Product name
- 6-Shogaol
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
6-Shogaol Chemical Properties,Usage,Production
Uses
[6]-Shogaol is an aromatic constituent of ginger and the chain-dehydroxylated analog of [6]-Gingerol. [6]-Shogaol has activity very similar to [6]-Gingerol and produced an inhibition of spontaneous motor activity, antipyretic and analgesic effects, and prolonged hexobarbital-induced sleeping time. [6]-Shogaol also has potent antitussive activity and affected the cortical EEG.
Definition
ChEBI: [6]-Shogaol is a monomethoxybenzene, a member of phenols and an enone.
Anticancer Research
6-Shogaol is the dehydrated product of 6-gingerol, extracted from the rhizome ofginger. Treatment of HCC cell line with 6-shogaol resulted in cells with apoptoticphenotypes, which showed signs of cell and nuclear shrinkage as well as substantialchromatin condensation. De-phosphorylation of PERK and activation of theexpression of CHOP initiate caspase cascade reaction inducing apoptosis inHCC. Two-dimensional gel electrophoretic analysis of proteome revealed that in response to the treatment with 6-shogaol, a significant stimulation was observed inproteins related to the ER stress, signifying that apoptosis induced by 6-shogoal didinvolve ER stress. Cells showed marked rise in the UPR target expression, HSP70,Grp94, Grp78/Bip and the other ER chaperones on exposure to 6-shogoal in a time-dependentmanner, which elicited activation of caspase-3 and degradation of polyADP ribose polymerase (PARP). Various ER chaperone proteins improve adaptationof cancer cells to hypoxic environment and aid in developing resistance againstanticancer therapy (Zorzi and Bonvini 2011; Urra et al. 2016). Screening of specificinhibitors of Grp78 as antitumour agents (Hu et al. 2012; Liu et al. 2013; Venkatesanet al. 2015) implies that inhibition of Grp78/Bip is a very promising anticancerstrategy. HCC cells are selectively killed by 6-shogaol in the absence of anynoticeable toxic consequence on normal healthy cells and very little toxicity asstudied on SMMC7721 xenograft mice. Administration of 6-shogaol and salubrinaltogether for distinct time intervals resulted in significant increase in ER stress in thecell. It appears that 6-shogaol in combination with salubrinal has great therapeuticvalue against various malignancies including HCC (Hu et al. 2012).
6-Shogaol Preparation Products And Raw materials
Raw materials
Preparation Products
6-Shogaol Suppliers
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View Lastest Price from 6-Shogaol manufacturers
- Product
- 3-Isothioureidopropionic acid 555-66-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-16
- Product
- 6-Shogaol 555-66-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-02-25
- Product
- 6-Shogaol 555-66-8
- Price
- US $0.00/ml
- Min. Order
- 0.1ml
- Purity
- ≥98%(HPLC)
- Supply Ability
- 100 ml
- Release date
- 2020-03-05