2-Phenoxyaniline

Product Name: 2-Phenoxyaniline
CAS No.: 2688-84-8
Chemical Name: 2-Phenoxyaniline
Synonyms: Phenoxyaniline;2-Ade;NSC 39655;AKOS B020146;2-PhenoxyaniL;AURORA KA-7802;2-phenoxy-anilin;O-PHENOXYANILINE;2-PHENOXYANILINE;o-phenoxy-anilin
CBNumber: CB4754493
Molecular Formula: C12H11NO
Formula Weight: 185.22
MOL File: 2688-84-8.mol

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2-Phenoxyaniline Property

Melting point:: 47-49 °C(lit.)
Boiling point:: 170 °C18 mm Hg(lit.)
Density: 1.0936 (rough estimate)
refractive index: 1.5300 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Slightly soluble in chloroform and methanol.
pka: 3.78±0.10(Predicted)
form: Crystalline Powder or Flakes
color: Brown to gray
BRN: 777766
Stability:: Hygroscopic
CAS DataBase Reference: 2688-84-8(CAS DataBase Reference)
NIST Chemistry Reference: 2-Aminodiphenyl ether(2688-84-8)
EPA Substance Registry System: o-Phenoxyaniline (2688-84-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-22
Safety Statements: 26-37/39-36/37/39-36
RIDADR: 2811
WGK Germany: 3
RTECS: BY7940000
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29222990
Toxicity: LD50 ivn-mus: 212 mg/kg TXCYAC 8,347,77

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 346683
Product name: 2-Phenoxyaniline
Purity: 99%
Packaging: 25g
Price: $29
Updated: 2025/07/31

Sigma-Aldrich

Product number: 346683
Product name: 2-Phenoxyaniline
Purity: 99%
Packaging: 500g
Price: $306.85
Updated: 2025/07/31

TCI Chemical

Product number: A1142
Product name: 2-Aminodiphenyl Ether
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: A1142
Product name: 2-Aminodiphenyl Ether
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $297
Updated: 2025/07/31

TRC

Product number: P298200
Product name: 2-Phenoxylaniline
Packaging: 25g
Price: $275
Updated: 2021/12/16

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2-Phenoxyaniline Chemical Properties,Usage,Production

Chemical Properties

Whitetolightyellowcrystalpowde

Uses

2-Phenoxyaniline serves as an antiinflammatory agent that inhibits preferentially COX-2 over COX-1. It is used in the preparation of sodium primary amide complex, 4-methyl-2-(2-phenoxyphenyl)azo-phenol and 2-acetoaminodiphenyl ether. Further, it is used to form complexes with beta-cyclodextrin.

Uses

2-Phenoxyaniline may be used in the preparation of sodium primary amide complex, 2-PhOC₆H₄NHNa·NMe[(CH₂)₂NMe₂]₂. It was used in the preparation of 2-acetoaminodiphenyl ether. It may be used in the preparation of 4-methyl-2-(2-phenoxyphenyl)azo-phenol.

General Description

2-Phenoxyaniline forms crystalline 2:1 (host-to-guest) inclusion complexes with β-cyclodextrin.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.

Synthesis

591-50-4

95-55-6

2688-84-8

General procedure: all reactions were carried out under air atmosphere. Iodobenzene (1.0 mmol), o-aminophenol (1.0 mmol), CuI (0.1 mmol), 1-(α-aminobenzyl)-2-naphthol (0.2 mmol), and K2CO3 (2.0 equiv.) were dissolved in 3 mL of DMSO, and the reaction was carried out for 24 hr at 120 °C. The reaction process was monitored by gas chromatography (GC). Upon completion of the reaction, the catalyst was removed by filtration and the product was extracted with ethyl acetate (EtOAc). The organic layers were combined and dried with anhydrous MgSO4 for 12 hours. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (10:1, v/v) to afford the target compound 2-aminodiphenyl ether.

References

[1] Synthetic Communications, 2014, vol. 44, # 17, p. 2468 - 2477
[2] Tetrahedron Letters, 2014, vol. 55, # 51, p. 7082 - 7088

2-Phenoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

Triclosan

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2-Phenoxyaniline Suppliers

Americas 1 Austria 1 Belgium 2 Canada 3 China 263 Europe 2 Germany 6 India 34 Japan 4 Slovakia 1 Switzerland 4 Ukraine 2 United Kingdom 12 United States 48 Global 383

J & K SCIENTIFIC LTD.

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Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from 2-Phenoxyaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Phenoxyaniline 2688-84-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-05

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2-Phenoxyaniline 2688-84-8
Price: US $65.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-06

Henan Fengda Chemical Co., Ltd

Product: 2-Phenoxyaniline 2688-84-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

2688-84-8, 2-PhenoxyanilineRelated Search:

Phenylhydrazine PHENYL VALERATE Dimethyl ether C8E3 4,4'-Oxydiphthalic anhydride Triclosan 4,4'-Oxydianiline Ethylbenzene Diphenyl ether 4-Nitro-2-phenoxyaniline NiMesulide EP IMpurity E N-(Methylsulfonyl)-4'-nitro-2'-phenoxyMethanesulfonanilide (2-PHENOXY)METHYLSULFONYLANILINE 2-(p-tolyloxy)aniline 2-AMINO-4,4'-DICHLORODIPHENYL ETHER 5-Chloro-2-(2-chlorophenoxy)aniline Diethyl ether Phenoxazine

AURORA KA-7802

2-AMINOPHENYL PHENYL ETHER

2-AMINODIPHENYL ETHER

2-PHENOXYANILINE

AKOS B020146

O-PHENOXYANILINE

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2-phenoxy-anilin

2-phenoxy-benzenamin

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o-Aminophenyl phenyl ether

o-aminophenylphenylether

o-phenoxy-anilin

2-Aminodiphenyl ether~2-Aminophenyl phenyl ether

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2-AMINODIPHENYLETHER(2-PHENOXYANILINE)

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Ortho Phenoxy Aniline (2-Amino Diphenyl Ether)

2-Aminophenyl Phenyl Ether 2-Phenoxyaniline

Phenoxyaniline

NiMesulide EP IMpurity C

Nimesulide Impurity 3(Nimesulide EP Impurity C)

Nimesulide impurity-C(EP/BP)

2-Phenoxylaniline

2-Aminodiphenyl Ether &gt

2-PhenoxyaniL

Nimesulide EP Impurity C (2-phenoxyaniline)

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Ortho Amino Di Phenyl Ether (2 PHENOXY ANILINE)

NIMESULIDE EP IMP C

NSC 39655

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C12H11O2N

C11 to C37

Building Blocks

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