TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- Product Name
- TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- CAS No.
- 635698-56-5
- Chemical Name
- TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- Synonyms
- 6-Boc-2,4-Dichloro-5,6,7,...;6-Boc-2,4-Cl2-5,7,8-H3-pyrido[4,3-d]pyrimidine;6-Boc-2,4-dichloro-7,8-dihydro-(5H)-pyrido[4,3-d]pyrimidine;6-Boc-2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine;2,4-Dichloro-,5,6,7,8-tetrahydro-6-Boc-Pyrido[4,3-d]pyrimidine;tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6...;Pyrido[4.3-d]pyriMidine-6(5H)-carboxylicacid. 2.4-dichloro-7.8-d;tert-Butyl 2,4-dichloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;ert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-6-carboxylate
- CBNumber
- CB4757308
- Molecular Formula
- C12H15Cl2N3O2
- Formula Weight
- 304.17
- MOL File
- 635698-56-5.mol
TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Property
- Boiling point:
- 423.1±45.0 °C(Predicted)
- Density
- 1.352±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.98±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B807123
- Product name
- tert-Butyl2,4-Dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FB141010
- Product name
- tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB141010
- Product name
- tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FB141010
- Product name
- tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FB141010
- Product name
- tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Chemical Properties,Usage,Production
Uses
tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate is a tert-butyl ester compound used in the synthesis of tetrahydropyrimidine derivatives as AHR modulators.
Synthesis
726697-13-8
24424-99-5
635698-56-5
2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (270 mg, 1.33 mmol) and di-tert-butyl dicarbonate (348 mg, 1.6 mmol) were used as the starting material, and 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine was dissolved in dichloromethane (30 mL) at 0 °C. Triethylamine (200 mg, 2.0 mmol) was then added and the reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the organic layer was separated by diluting the reaction mixture with dichloromethane (30 mL) and water (30 mL). The aqueous phase was further extracted with dichloromethane (30 mL x 2). All organic layers were combined, washed with brine and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the solvent was removed by concentration under reduced pressure. The resulting crude product was purified by fast column chromatography using a solvent mixture of hexane and ethyl acetate to afford N-BOC-2,4-dichloro-5,7,8-trihydropyrido[4,3-D]pyrimidine (300 mg, 74% yield). Mass spectrometry analysis (LRMS, M+H+): calculated value 305.17; measured value 305.24.
References
[1] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 172; 173
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9480 - 9497
TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Suppliers
- Tel
- Country
- China Hong Kong
- ProdList
- 878
- Advantage
- 55
View Lastest Price from TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE manufacturers
- Product
- TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 635698-56-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12