ChemicalBook > CAS DataBase List > 2,5-DICHLORO-4-FORMYLPYRIDINE

2,5-DICHLORO-4-FORMYLPYRIDINE

Product Name: 2,5-DICHLORO-4-FORMYLPYRIDINE
CAS No.: 102645-33-0
Chemical Name: 2,5-DICHLORO-4-FORMYLPYRIDINE
Synonyms: 2,5-DICHLORO-4-FORMY;2,5-DICHLORO-4-FORMYLPYRIDINE;2,5-Dichloroisonicotinaldehyde 97%;2,5-Dichloro-4-pyridinecarbaldehyde;2,5-dichloropyridine-4-carbaldehyde;2,5-DICHLOROPYRIDINE-4-CARBOXALDEHYDE;2,5-dichloro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 2,5-dichloro-;2,5-dichloro-3-forMylpyridine-4-carboxylic acid;2,5-DICHLORO-4-FORMYLPYRIDINE ISO 9001：2015 REACH
CBNumber: CB4771296
Molecular Formula: C6H3Cl2NO
Formula Weight: 176
MOL File: 102645-33-0.mol

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2,5-DICHLORO-4-FORMYLPYRIDINE Property

Melting point:: 73-74°
Boiling point:: 256.3±35.0 °C(Predicted)
Density: 1.488±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -3.62±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C6H3Cl2NO/c7-5-2-9-6(8)1-4(5)3-10/h1-3H
InChIKey: UIPSRNHDSBVXHY-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Cl)C(C=O)=C1

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: D436160
Product name: 2,5-Dichloro-4-pyridinecarboxaldehyde
Packaging: 1g
Price: $150
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y14221
Product name: 2,5-Dichloro-4-formylpyridine
Purity: 97%
Packaging: 1g
Price: $28
Updated: 2021/12/16

AK Scientific

Product number: N466
Product name: 2,5-Dichloro-4-formylpyridine
Packaging: 250mg
Price: $39
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD151286
Product name: 2,5-Dichloro-4-formylpyridine
Packaging: 50mg
Price: $86
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y14221
Product name: 2,5-Dichloro-4-formylpyridine
Purity: 97%
Packaging: 5g
Price: $110
Updated: 2021/12/16

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2,5-DICHLORO-4-FORMYLPYRIDINE Chemical Properties,Usage,Production

Uses

2,5-Dichloro-4-pyridinecarboxaldehyde, is an intermediate in the preparation of various pharmaceutical compounds. It is used in the synthesis of 2-Amino-5-aryl-pyridines as selective CB2 agonists.

Synthesis

16110-09-1

68-12-2

102645-33-0

General procedure for the synthesis of 2,5-dichloropyridine-4-carbaldehyde from 2,5-dichloropyridine and N,N-dimethylformamide: First, 2,5-dichloropyridine (27.0 g, 180 mmol) was dissolved in THF (65 mL), which was added via cannulae to a pre-cooled LDA solution at -78°C (100 mL of a 1.8 M solution of 180 mmol, dissolved in THF (80 mL)). After stirring the mixture at -78 °C for 30 min, a solution of DMF (21.1 mL, 271 mmol) in THF (25 mL) was added slowly via syringe. The reaction was kept at -78 °C for 3 h of continued stirring, followed by slow warming to room temperature. The reaction solution was slowly poured into a mixture of ice (800 mL) and hydrochloric acid (150 mL) and stirred for 20 minutes. The pH was adjusted to 9-10 with 3.0 M NaOH solution, followed by extraction with ether (2 x 500 mL). The organic layers were combined, dried and concentrated with MgSO4 to give the crude product as a light yellow solid. This solid was suspended in n-hexane with a small amount of EtOAc and boiled for 5 min before decanting the liquid and evaporating the solvent to give a yellow solid. Finally, purification by Biotage fast chromatography (using a 65i silica gel column loaded with DCM/EtOAc followed by heptane elution with an elution gradient of 20% EtOAc/heptane, 8 column volumes, and then kept at 5 column volumes) afforded the target compound, 2,5-dichloro pyridine-4-carboxaldehyde (17.9 g, 56% yield), as a light yellow solid.1H NMR ( 400 MHz, DMSO-d6) δ 7.85 (s, 1H), 8.76 (s, 1H), 10.22 (s, 1H).

References

[1] Patent: WO2011/27249, 2011, A2. Location in patent: Page/Page column 58
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[3] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 132
[4] Patent: WO2005/73232, 2005, A1. Location in patent: Page/Page column 34

2,5-DICHLORO-4-FORMYLPYRIDINE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Cyclohexane Diisopropylamine Tetrahydrofuran 2,5-Dichloropyridine n-Butyllithium

Preparation Products

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View Lastest Price from 2,5-DICHLORO-4-FORMYLPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 2,5-DICHLORO-4-FORMYLPYRIDINE 102645-33-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 2,5-DICHLORO-4-FORMYLPYRIDINE 102645-33-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-24

102645-33-0, 2,5-DICHLORO-4-FORMYLPYRIDINERelated Search:

2,6-Dichloropyridine-4-carboxaldehyde 2,3-DICHLORO-4-FORMYLPYRIDINE 2,3-DICHLORO-5-FORMYLPYRIDINE 2,6-DICHLORO-3-FORMYLPYRIDINE ethyl 2,5-dichloroisonicotinate 2,3,5-Trichloropyridine-4-carboxylic acid ETHYL 2,3,5-TRICHLORO-6-{[(DIMETHYLAMINO)CARBONOTHIOYL]THIO}ISONICOTINATE 2,3,5,6-Tetrachloropyridine-4-carboxylic acid ETHYL 2-(TERT-BUTYL)-3,6-DICHLORO-5-CYANOISONICOTINATE 2,5-Dichloroisonicotinic acid RARECHEM AL BW 2014 methyl 2,5-dichloroisonicotinate 2,5-DICHLORO-4-FORMYLPYRIDINE 2,3,5,6-TETRACHLOROPYRIDINE-4-CARBOXALDEHYDE 2,3,5-Trichloropyridine-4-carboxaldehyde 2,3,5,6-TETRACHLOROISONICOTINOYL CHLORIDE

2,5-Dichloroisonicotinaldehyde 97%

2,5-dichloro-4-pyridinecarboxaldehyde

4-Pyridinecarboxaldehyde, 2,5-dichloro-

2,5-dichloropyridine-4-carbaldehyde

2,5-DICHLOROPYRIDINE-4-CARBOXALDEHYDE

2,5-DICHLORO-4-FORMYLPYRIDINE

tert-butyl (3S,4S)-3-amino-4-methoxy-1-pyrrolidinecarboxylate hydrochloride

2,5-DICHLORO-4-FORMY

2,5-dichloro-3-forMylpyridine-4-carboxylic acid

2,5-DICHLORO-4-FORMYLPYRIDINE ISO 9001：2015 REACH

2,5-Dichloro-4-pyridinecarbaldehyde

102645-33-0

Boronic Acid

Pyridine

Pyridines

Chlorinated heterocyclic series