ChemicalBook > CAS DataBase List > ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

Product Name: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
CAS No.: 343-67-9
Chemical Name: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
Synonyms: Ethyl 2-trifluoromethyl-4-oxopyrimidine-5-carboxylate;ethyl6-oxo-2-(trifluoromethyl)-1H-pyrimidine-5-carboxylate;ethyl 4-hydroxy-2-(trifluoromethyl)-5-pyrimidinecarboxylate;ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;ethyl 6-oxo-2-(trifluoromethyl)-1,6-dihydropyrimidine-5-carb...;Ethyl 4-hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate ,97%;ethyl 6-oxo-2-(trifluoroMethyl)-1,6-dihydropyriMidine-5-carboxylate;4-Hydroxy-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester;ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH;5-Pyrimidinecarboxylic acid, 1,6-dihydro-6-oxo-2-(trifluoromethyl)-, ethyl ester
CBNumber: CB4789028
Molecular Formula: C8H7F3N2O3
Formula Weight: 236.15
MOL File: 343-67-9.mol

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ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Property

Melting point:: 315-316°
Density: 1.50
storage temp.: 2-8°C
pka: 4.75±0.50(Predicted)

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Safety

Hazard Codes: Xi
Risk Statements: 48-20/21/22
Safety Statements: 3/7/9-37/39
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E945885
Product name: Ethyl4-Hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-3-42
Product name: Ethyl 4-hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate
Purity: 95%
Packaging: 1g
Price: $145
Updated: 2021/12/16

Matrix Scientific

Product number: 047151
Product name: Ethyl 4-hydroxy-2-(trifluoromethyl)-5-pyrimidinecarboxylate
Purity: >95%
Packaging: 500mg
Price: $181
Updated: 2021/12/16

Matrix Scientific

Product number: 047151
Product name: Ethyl 4-hydroxy-2-(trifluoromethyl)-5-pyrimidinecarboxylate
Purity: >95%
Packaging: 1g
Price: $228
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-3-42
Product name: Ethyl 4-hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate
Purity: 95%
Packaging: 5G
Price: $395
Updated: 2021/12/16

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ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Ethyl 4-Hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate is a useful reagent in the study of NF-κB and AP-1 gene inhibitors.

Synthesis

7732-18-5

87-13-8

343-67-9

Diethyl ethoxymethylenemalonate (35.0 g, 162 mmol) and trifluoroacetic acid (18 g, 162 mmol) were used as raw materials, which were dissolved in ethanol (200 mL) and sodium ethoxide (11.0 g, 162 mmol) was added. The reaction mixture was heated to reflux for 6 hours. After completion of the reaction, the reaction mixture was concentrated and water (48 mmol) was added. The resulting solid was collected by filtration, washed sequentially with ether (300 mL) and water (200 mL), and dried to give ethyl 4-hydroxy-2-trifluoromethylpyrimidine-5-carboxylate (21 g, 50% yield). The melting point of the product was >220 °C (decomposition); 1H NMR (DMSO-d6) δ 8.38,4.16 (q, 2H), 1.25 (q, 3H).

References

[1] Patent: US5935966, 1999, A

ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 343-67-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

343-67-9, ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATERelated Search:

2-Trifluoromethylpyrimidine 4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-HYDROXY-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-Hydroxy-2-(trifluoromethyl)pyrimidine ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl2-methylpyrimidine-5-carboxylate 2-METHYL-4-HYDROXY-5-METHOXYMETHYLPYRIMIDINE 4-HYDROXY-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID 5-(HYDROXYMETHYL)-2-METHYLPYRIMIDIN-4-OL 2-Trifluoromethyl-pyrimidine-5-carboxylic acid methyl ester 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI) 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID METHYL ESTER ETHYL-2-HYDROXY-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE DISC 04/24/02 SODIUM 5-(ETHOXYCARBONYL)-2-(TRIFLUOROMETHYL)PYRIMIDIN-4-OLATE

ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

ethyl 4-hydroxy-2-(trifluoromethyl)-5-pyrimidinecarboxylate

Ethyl 2-trifluoromethyl-4-oxopyrimidine-5-carboxylate

Ethyl 4-hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate ,97%

ethyl 6-oxo-2-(trifluoroMethyl)-1,6-dihydropyriMidine-5-carboxylate

5-(Ethoxycarbonyl)-4-hydroxy-2-(trifluoromethyl)pyrimidine, 5-(Ethoxycarbonyl)-4-hydroxy-2-(trifluoromethyl)-1,3-diazine

4-Hydroxy-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester

5-Pyrimidinecarboxylic acid, 1,6-dihydro-6-oxo-2-(trifluoromethyl)-, ethyl ester

ethyl6-oxo-2-(trifluoromethyl)-1H-pyrimidine-5-carboxylate

ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH

ethyl 6-oxo-2-(trifluoromethyl)-1,6-dihydropyrimidine-5-carb...

343-67-9

Fluorine series

pyrimidine