4-BROMOPYRIDINE-2-CARBALDEHYDE

Product Name: 4-BROMOPYRIDINE-2-CARBALDEHYDE
CAS No.: 131747-63-2
Chemical Name: 4-BROMOPYRIDINE-2-CARBALDEHYDE
Synonyms: 4-BROMOPICOLINALDEHYDE;4-Bromopyridine-2-carbaL;4-broMopyridin-2-carbaldehyde;4-BROMOPYRIDINE-2-CARBALDEHYD;4-BROMO-2-PYRIDINECARBALDEHYDE;4-BROMOPYRIDINE-2-CARBALDEHYDE;2-Pyridinecarboxaldehyde,4-broMo;4-broMo-2-pyridinecarboxaldehyde;4-Bromopyridine 2-carboxaldehyde;4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2
CBNumber: CB4789684
Molecular Formula: C6H4BrNO
Formula Weight: 186.01
MOL File: 131747-63-2.mol

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4-BROMOPYRIDINE-2-CARBALDEHYDE Property

Boiling point:: 244.0±20.0 °C(Predicted)
Density: 1.683±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), DMSO (Sparingly)
form: solid
pka: 1.78±0.10(Predicted)
color: Off-white to light yellow

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B686135
Product name: 4-Bromopyridine-2-carboxaldehyde
Packaging: 1g
Price: $140
Updated: 2021/12/16

TRC

Product number: B686135
Product name: 4-Bromopyridine-2-carboxaldehyde
Packaging: 10g
Price: $690
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142654
Product name: 4-Bromopicolinaldehyde
Packaging: 25g
Price: $937.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036518
Product name: 4-BROMOPICOLINALDEHYDE
Purity: 95.00%
Packaging: 1G
Price: $985
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036518
Product name: 4-BROMOPICOLINALDEHYDE
Purity: 95.00%
Packaging: 5G
Price: $1476.09
Updated: 2021/12/16

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4-BROMOPYRIDINE-2-CARBALDEHYDE Chemical Properties,Usage,Production

Uses

4-Bromopyridine-2-carboxaldehyde is a reagent used to synthesize Curcumin (C838500) analogues. It can also be used to prepare 1,4-dihydropyridine calcium antagonists.

Synthesis

131747-45-0

131747-63-2

General procedure for the synthesis of 4-bromopyridine-2-carboxaldehyde from 2-hydroxymethyl-4-bromopyridine: 3L of dichloromethane (DCM) was added to a 5L three-necked flask under nitrogen protection, and cooled to -60 °C. During the cooling process, 240 g of oxalyl chloride was added slowly and dropwise. Maintaining the reaction temperature at -60 °C, 295.6 g of dimethyl sulfoxide (DMSO) was added dropwise to the reaction system and held for 30 min after the dropwise addition. Subsequently, 237.5 g of 2-hydroxymethyl-4-bromopyridine (Cpd 3) was slowly added dropwise at -60 °C and the reaction was continued at -65 °C for 1 hour. At this temperature, 3.5 equivalents of triethylamine (TEA) was added, and the reaction solution was allowed to stand before the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the target product 4-bromopyridine-2-carboxaldehyde (Compound 4) was purified by column chromatography to give 177.2 g in 75% yield.

References

[1] Patent: US2010/125082, 2010, A1. Location in patent: Page/Page column 24
[2] Tetrahedron, 1997, vol. 53, # 24, p. 8257 - 8268
[3] Patent: CN108516953, 2018, A. Location in patent: Paragraph 0067-0068; 0074-0075; 0076-0083
[4] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[5] MedChemComm, 2015, vol. 6, # 7, p. 1252 - 1259

4-BROMOPYRIDINE-2-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMOPYRIDINE-2-CARBALDEHYDE Suppliers

China 151 Germany 3 India 3 United Kingdom 2 United States 17 Global 176

PharmaBlock Sciences (Nanjing),Inc.

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Pure Chemistry Scientific Inc.

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Shanghai Boc Chemical Co.,Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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Shanghai Ennopharm Co., Ltd.

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View Lastest Price from 4-BROMOPYRIDINE-2-CARBALDEHYDE manufacturers

Dideu Industries Group Limited

Product: 4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-18

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Bromopicolinaldehyde 131747-63-2
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

Career Henan Chemical Co

Product: 4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-20

131747-63-2, 4-BROMOPYRIDINE-2-CARBALDEHYDERelated Search:

4-BROMOPYRIDINE-2-CARBALDEHYDE 4-BROMOPYRIDINE-2,6-DICARBOXYLIC ACID 4-BROMO-PYRIDINE-2,6-DICARBOXYLIC ACID DIAMIDE 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 4-Bromo-pyridine-2-carboxylic acid ethyl ester 4-Bromopyridine-2-carboxylic acid 4-BROMOQUINOLINE-2-CARBOXYLIC ACID Dimethyl 2-bromo-2,6-pyridinedicarboxylate 4-BROMOQINOLINE-2-CARBOXALDEHYDE 4-BROMO-6-METHYL-PYRIDINE-2-CARBALDEHYDE Diethyl 4-bromopyridine-2,6-dicarboxylate 4-Bromo-2,6-diformylpyridine 1-(4-BROMOPYRIDIN-2-YL)-2,2,2-TRIFLUOROETHANONE 2-AMINO-4-BROMO-6-CARBOXYPYRIDINE METHYL ESTER 4-BROMO-6-METHYL-PYRIDINE-2-CARBOXYLIC ACID 4-BROMO-3-METHYL-PYRIDINE-2-CARBALDEHYDE 4-BROMO-6-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 4-BROMO-6-METHYLPYRIDINE-2-CARBOXAMIDE

4-BROMOPICOLINALDEHYDE

4-Bromopyridine 2-carboxaldehyde

4-BROMOPYRIDINE-2-CARBALDEHYDE

4-broMopyridin-2-carbaldehyde

4-broMo-2-pyridinecarboxaldehyde

2-Pyridinecarboxaldehyde,4-broMo

4-Bromopyridine-2-carbaL

4-BROMO-2-PYRIDINECARBALDEHYDE

4-BROMOPYRIDINE-2-CARBALDEHYDE ISO 9001：2015 REACH

4-BROMOPYRIDINE-2-CARBALDEHYDE 131747-63-2

4-BROMOPYRIDINE-2-CARBALDEHYD

131747-63-2

Pyridines

Heterocycle-Pyridine series