Dimethyl 2-bromo-2,6-pyridinedicarboxylate
- Product Name
- Dimethyl 2-bromo-2,6-pyridinedicarboxylate
- CAS No.
- 162102-79-6
- Chemical Name
- Dimethyl 2-bromo-2,6-pyridinedicarboxylate
- Synonyms
- dimethyl 4-bromopyridine-2,6-dicarboxylate;Dimethyl 4-bromo-2,6-pyridinedicarboxylate;Dimethyl 2-bromo-2,6-pyridinedicarboxylate;2,6-diMethyl 4-broMopyridine-2,6-dicarboxylate;4-BroMo-pyridine-2,6-dicarboxylic acid diMethyl este;2,6-Pyridinedicarboxylic acid, 4-bromo-, 2,6-dimethyl ester
- CBNumber
- CB41501595
- Molecular Formula
- C9H8BrNO4
- Formula Weight
- 274.07
- MOL File
- 162102-79-6.mol
Dimethyl 2-bromo-2,6-pyridinedicarboxylate Property
- Melting point:
- 176 °C
- Boiling point:
- 369.6±37.0 °C(Predicted)
- Density
- 1.569±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.40±0.10(Predicted)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C9H8BrNO4/c1-14-8(12)6-3-5(10)4-7(11-6)9(13)15-2/h3-4H,1-2H3
- InChIKey
- WYROXHCDUWIUMW-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(C(OC)=O)=CC(Br)=C1
Safety
- Safety Statements
- 24/25
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- FD144342
- Product name
- Dimethyl 4-bromopyridine-2,6-dicarboxylate
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD144342
- Product name
- Dimethyl 4-bromopyridine-2,6-dicarboxylate
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- JK1018934
- Product name
- Dimethyl4-bromopyridine-2,6-dicarboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- FD144342
- Product name
- Dimethyl 4-bromopyridine-2,6-dicarboxylate
- Packaging
- 2g
- Price
- $650
- Updated
- 2021/12/16
- Product number
- FD144342
- Product name
- Dimethyl 4-bromopyridine-2,6-dicarboxylate
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
Dimethyl 2-bromo-2,6-pyridinedicarboxylate Chemical Properties,Usage,Production
Synthesis
138-60-3
162102-79-6
The general procedure for the synthesis of pyridine 4-bromo-2,6-dicarboxylic acid methyl ester from 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid was as follows: compound 1 was prepared by a modified method from literature [29]. Tribenzoic acid monohydrate (2.20 g, 10.9 mmol) and phosphorus pentabromide (23.4 g, 54.3 mmol, 5 eq.) were heated to 90 °C under nitrogen protection and the reaction was maintained for 2 hours. Upon completion of the reaction, the dark red melt was cooled to room temperature and dissolved by addition of chloroform (25 mL). The reaction mixture was filtered and the filtrate was cooled in an ice bath (0 °C) and methanol (90 mL) was added slowly to promote crystallization. Crystallization was induced by scraping and the resulting crystalline solid was collected by vacuum filtration and dried under vacuum to afford compound 1 as a white crystalline solid (2.82 g, 86% yield).1H NMR (300 MHz, CDCl3) δ 8.45 (s, 2H), 4.02 (s, 6H).
References
[1] Journal of Inorganic Biochemistry, 2016, vol. 162, p. 253 - 262
[2] Organic Letters, 2011, vol. 13, # 3, p. 442 - 445
[3] Chemical Communications, 2012, vol. 48, # 80, p. 10025 - 10027
[4] Chemical Communications, 2014, vol. 50, # 68, p. 9665 - 9668
[5] Dalton Transactions, 2017, vol. 46, # 16, p. 5229 - 5239
Dimethyl 2-bromo-2,6-pyridinedicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dimethyl 2-bromo-2,6-pyridinedicarboxylate manufacturers
- Product
- Dimethyl 2-bromo-2,6-pyridinedicarboxylate 162102-79-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25