ChemicalBook > CAS DataBase List > Dimethyl 2-bromo-2,6-pyridinedicarboxylate

Dimethyl 2-bromo-2,6-pyridinedicarboxylate

Product Name
Dimethyl 2-bromo-2,6-pyridinedicarboxylate
CAS No.
162102-79-6
Chemical Name
Dimethyl 2-bromo-2,6-pyridinedicarboxylate
Synonyms
dimethyl 4-bromopyridine-2,6-dicarboxylate;Dimethyl 4-bromo-2,6-pyridinedicarboxylate;Dimethyl 2-bromo-2,6-pyridinedicarboxylate;2,6-diMethyl 4-broMopyridine-2,6-dicarboxylate;4-BroMo-pyridine-2,6-dicarboxylic acid diMethyl este;2,6-Pyridinedicarboxylic acid, 4-bromo-, 2,6-dimethyl ester
CBNumber
CB41501595
Molecular Formula
C9H8BrNO4
Formula Weight
274.07
MOL File
162102-79-6.mol
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Dimethyl 2-bromo-2,6-pyridinedicarboxylate Property

Melting point:
176 °C
Boiling point:
369.6±37.0 °C(Predicted)
Density 
1.569±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.40±0.10(Predicted)
Appearance
White to light brown Solid
InChI
InChI=1S/C9H8BrNO4/c1-14-8(12)6-3-5(10)4-7(11-6)9(13)15-2/h3-4H,1-2H3
InChIKey
WYROXHCDUWIUMW-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)=NC(C(OC)=O)=CC(Br)=C1
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Safety

Safety Statements 
24/25
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD144342
Product name
Dimethyl 4-bromopyridine-2,6-dicarboxylate
Packaging
100mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD144342
Product name
Dimethyl 4-bromopyridine-2,6-dicarboxylate
Packaging
250mg
Price
$150
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK1018934
Product name
Dimethyl4-bromopyridine-2,6-dicarboxylate
Purity
95%
Packaging
250mg
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD144342
Product name
Dimethyl 4-bromopyridine-2,6-dicarboxylate
Packaging
500mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD144342
Product name
Dimethyl 4-bromopyridine-2,6-dicarboxylate
Packaging
1g
Price
$400
Updated
2021/12/16
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Dimethyl 2-bromo-2,6-pyridinedicarboxylate Chemical Properties,Usage,Production

Synthesis

138-60-3

162102-79-6

The general procedure for the synthesis of pyridine 4-bromo-2,6-dicarboxylic acid methyl ester from 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid was as follows: compound 1 was prepared by a modified method from literature [29]. Tribenzoic acid monohydrate (2.20 g, 10.9 mmol) and phosphorus pentabromide (23.4 g, 54.3 mmol, 5 eq.) were heated to 90 °C under nitrogen protection and the reaction was maintained for 2 hours. Upon completion of the reaction, the dark red melt was cooled to room temperature and dissolved by addition of chloroform (25 mL). The reaction mixture was filtered and the filtrate was cooled in an ice bath (0 °C) and methanol (90 mL) was added slowly to promote crystallization. Crystallization was induced by scraping and the resulting crystalline solid was collected by vacuum filtration and dried under vacuum to afford compound 1 as a white crystalline solid (2.82 g, 86% yield).1H NMR (300 MHz, CDCl3) δ 8.45 (s, 2H), 4.02 (s, 6H).

References

[1] Journal of Inorganic Biochemistry, 2016, vol. 162, p. 253 - 262
[2] Organic Letters, 2011, vol. 13, # 3, p. 442 - 445
[3] Chemical Communications, 2012, vol. 48, # 80, p. 10025 - 10027
[4] Chemical Communications, 2014, vol. 50, # 68, p. 9665 - 9668
[5] Dalton Transactions, 2017, vol. 46, # 16, p. 5229 - 5239

Dimethyl 2-bromo-2,6-pyridinedicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dimethyl 2-bromo-2,6-pyridinedicarboxylate manufacturers

Career Henan Chemical Co
Product
Dimethyl 2-bromo-2,6-pyridinedicarboxylate 162102-79-6
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-25

162102-79-6, Dimethyl 2-bromo-2,6-pyridinedicarboxylateRelated Search:

6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE 4-Bromo-2,6-diformylpyridine 4-BROMOPYRIDINE-2-CARBALDEHYDE 2,6-Pyridinedicarboxylic acid monomethyl ester Dimethyl 2,6-Pyridinedicarboxylate 4-BROMOPYRIDINE-2,6-DICARBOXYLIC ACID 4-BROMO-6-METHYL-PYRIDINE-2-CARBALDEHYDE 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 4-Bromopyridine-2,6-dimethanol 4-Bromo-2-pyridinemethanol Dimethyl 2-bromo-2,6-pyridinedicarboxylate Diethyl 4-bromopyridine-2,6-dicarboxylate 4-Bromopyridine-2-carboxylic acid 4-Bromo-2,6-dimethylpyridine

  • Dimethyl 2-bromo-2,6-pyridinedicarboxylate
  • Dimethyl 4-bromo-2,6-pyridinedicarboxylate
  • dimethyl 4-bromopyridine-2,6-dicarboxylate
  • 2,6-diMethyl 4-broMopyridine-2,6-dicarboxylate
  • 4-BroMo-pyridine-2,6-dicarboxylic acid diMethyl este
  • 2,6-Pyridinedicarboxylic acid, 4-bromo-, 2,6-dimethyl ester
  • 162102-79-6
  • pharmacetical