4-Bromo-2-pyridinemethanol
- Product Name
- 4-Bromo-2-pyridinemethanol
- CAS No.
- 131747-45-0
- Chemical Name
- 4-Bromo-2-pyridinemethanol
- Synonyms
- (4-Bromopyridin-2-yl)methanol;4-BROMO-2-PYRIDINEMETHANOL;4-Bromopyridine-2-methanol;(4-BroMo-2-pyridyl)Methanol;2-Pyridinemethanol, 4-bromo-;4-Bromopyridine-2-methano...;4-BroMo-2-pyridineMethanol HCl;1-(4'-bromopyridin-2'-yl)methanol;4-Bromo-2-(hydroxymethyl)pyridine;4-Bromo-2-pyridinemethanol ISO 9001：2015 REACH
- CBNumber
- CB21010592
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 131747-45-0.mol
4-Bromo-2-pyridinemethanol Property
- Melting point:
- 52.0 to 56.0 °C
- Boiling point:
- 105°C/0.5mmHg(lit.)
- Density
- 1.668±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to lump
- pka
- 13.09±0.10(Predicted)
- color
- White to Light yellow to Light orange
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B5291
- Product name
- 4-Bromo-2-pyridinemethanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $130
- Updated
- 2025/07/31
- Product number
- B687260
- Product name
- 4-Bromo-2-pyridinemethanol
- Packaging
- 10g
- Price
- $990
- Updated
- 2021/12/16
- Product number
- HCH0143419
- Product name
- (4-BROMOPYRIDIN-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1845.69
- Updated
- 2021/12/16
- Product number
- HCH0143419
- Product name
- (4-BROMOPYRIDIN-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $5384.61
- Updated
- 2021/12/16
- Product number
- FB139879
- Product name
- (4-Bromopyridin-2-yl)methanol
- Packaging
- 25g
- Price
- $675
- Updated
- 2021/12/16
4-Bromo-2-pyridinemethanol Chemical Properties,Usage,Production
Uses
4-Bromo-2-pyridinemethanol is used as a reagent to synthesize bisphosphonate derivatives, compounds that inhibit farnesyl pyrophosphate synthase (an important enzyme in isoprenoid biosynthesis).
Synthesis
29681-42-3
131747-45-0
Step 1: Methyl 4-bromopyridine-2-carboxylate (990 mg, 4.58 mmol) and ethanol (250 mL) were added to a 250 mL reaction flask. Sodium borohydride (380 mg, 10 mmol) was added slowly in batches under stirring conditions. The reaction mixture was stirred at room temperature and under nitrogen protection for 18 hours. After completion of the reaction, 5 mL of acetone was added to the system and stirring was continued for 15 minutes. The reaction solution was filtered, and the filtrate was concentrated and extracted by adding ethyl acetate and water to separate the organic and aqueous phases. The organic phase was dried and concentrated to give 2-hydroxymethyl-4-bromopyridine (yellow liquid, 760 mg, 88% yield), and the crude product was used directly in the next reaction. (MS data: [M + 1] 187.9)
References
[1] Patent: WO2012/78915, 2012, A1. Location in patent: Page/Page column 95-96
[2] Patent: EP3150592, 2017, A1. Location in patent: Paragraph 0201; 0202; 0203
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 18, p. 2866 - 2875
4-Bromo-2-pyridinemethanol Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2-pyridinemethanol Suppliers
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View Lastest Price from 4-Bromo-2-pyridinemethanol manufacturers
- Product
- 4-Bromo-2-pyridinemethanol 131747-45-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-18
- Product
- 4-Bromo-2-pyridinemethanol 131747-45-0
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12
- Product
- 4-Bromo-2-pyridinemethanol 131747-45-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24