4-Bromo-pyridine-2-carboxylic acid ethyl ester
- Product Name
- 4-Bromo-pyridine-2-carboxylic acid ethyl ester
- CAS No.
- 62150-47-4
- Chemical Name
- 4-Bromo-pyridine-2-carboxylic acid ethyl ester
- Synonyms
- ethyl 4-broMopicolinate;Ethyl 4-bromo-2-pyridinecarboxylate;Ethyl 4-bromopyridine-2-carboxylate;4-Bromo-pyridine-2-carboxylic acid ethyl ester;2-Pyridinecarboxylic acid, 4-broMo-, ethyl ester;4-Bromo-pyridine-2-carboxylic acid ethyl ester ISO 9001：2015 REACH
- CBNumber
- CB91856784
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 62150-47-4.mol
4-Bromo-pyridine-2-carboxylic acid ethyl ester Property
- Melting point:
- 43 - 44oC
- Boiling point:
- 299.3±20.0 °C(Predicted)
- Density
- 1.501±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -0.11±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E900803
- Product name
- Ethyl4-Bromopicolinate
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FB146933
- Product name
- 4-Bromopyridine-2-carboxylic acid ethylester
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- J50988
- Product name
- Ethyl4-bromopicolinate
- Packaging
- 5g
- Price
- $255
- Updated
- 2021/12/16
- Product number
- FB146933
- Product name
- 4-Bromopyridine-2-carboxylic acid ethylester
- Packaging
- 2g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FB146933
- Product name
- 4-Bromopyridine-2-carboxylic acid ethylester
- Packaging
- 5G
- Price
- $530
- Updated
- 2021/12/16
4-Bromo-pyridine-2-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Chemical Properties
Yellow-white solid
Uses
Ethyl 4-Bromopicolinate is a useful compound for the development of inhibitors of murine adipose triglyceride lipase.
Synthesis
617-35-6
19524-06-2
62150-47-4
1. 1700 g of ethyl pyruvate is slowly added dropwise to 1400 g of a 35% hydrogen peroxide solution at -20°C to -10°C (preferably -10°C). 2. after holding the reaction for 30 minutes, 1400 g of 4-bromopyridine hydrochloride (compound 1) was added to ice water. 3. The pH of the reaction mixture was adjusted to 8-9 using potassium carbonate at a temperature below 10 °C. 4. The reaction mixture was extracted twice with 7 L of dichloromethane (DCM), the organic phases were combined and dried. 5. The dried organic phase was transferred to a 50L reaction flask and 1.4L of water, 4073g of ferrous sulfate heptahydrate and 448mL of concentrated sulfuric acid were added and stirred at room temperature. 6. Under the condition of -10°C to 0°C (preferably -5°C), the pre-prepared ethyl pyruvate/hydrogen peroxide solution was added and the reaction was continued for 4 hours. 7. After completion of the reaction, the reaction mixture was extracted with 7 L of water and the solvent was removed by rotary evaporation to afford 1390 g of ethyl 4-bromopyridine-2-carboxylate (compound 2) in 82% yield.
References
[1] Patent: CN108516953, 2018, A. Location in patent: Paragraph 0067-0071; 0076-0083
[2] Patent: CN105153023, 2018, B. Location in patent: Paragraph 0059; 0060-0061
4-Bromo-pyridine-2-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-pyridine-2-carboxylic acid ethyl ester manufacturers
- Product
- 4-Bromo-pyridine-2-carboxylic acid ethyl ester 62150-47-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
- Product
- 4-Bromo-pyridine-2-carboxylic acid ethyl ester 62150-47-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12
- Product
- 4-Bromo-pyridine-2-carboxylic acid ethyl ester 62150-47-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12