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COLIVELIN

Product Name
COLIVELIN
CAS No.
867021-83-8
Chemical Name
COLIVELIN
Synonyms
COLIVELIN;Colivelin (human);SALLRSIPAPAGASRLLLLTGEIDLP;SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO;H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH;Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury;Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt;L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-
CBNumber
CB4795124
Molecular Formula
C119H206N32O35
Formula Weight
2645.15
MOL File
867021-83-8.mol
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COLIVELIN Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
form 
solid
color 
White
Water Solubility 
Soluble to 1 mg/ml in 20% ethanol / water
InChIKey
PTTAQOYOJJTWFD-PKHBOWMQNA-N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24239
Product name
Colivelin
Purity
≥95%
Packaging
500μg
Price
$242
Updated
2024/03/01
Cayman Chemical
Product number
24239
Product name
Colivelin
Purity
≥95%
Packaging
1mg
Price
$364
Updated
2024/03/01
Tocris
Product number
3945
Product name
Colivelin
Packaging
500U
Price
$314
Updated
2021/12/16
TRC
Product number
C641530
Product name
Colivelin
Packaging
5mg
Price
$2475
Updated
2021/12/16
Usbiological
Product number
255021
Product name
Colivelin
Packaging
500ug
Price
$573
Updated
2021/12/16
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COLIVELIN Chemical Properties,Usage,Production

Description

Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity. It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid β (1-43) (Aβ43) when used at concentrations of 10 and 100 fM, respectively. Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory. Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of Aβ25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).

Uses

Colivelin is a peptide that offers neuroprotective effects against Alzheimer''s Disease (AD). It is also an activator of STAT3, a transcription factor involved with the JAK2/STAT3 pathway. Aberration in this pathway is linked to the pathogenesis of AD. Neuroprotective product.

Mechanism of action

Colivelin is a humanized peptide with neuroprotective effects that has a strong ability to fight against Aβ deposition, neuronal apoptosis, and synaptic plasticity defects in neurodegenerative diseases. Its neuroprotective pathway can be related to activating the STAT3 signaling pathway by inhibiting axonal damage and neuronal death in brain tissue. In addition, Colivelin may also occur through Ca2+/calmodulin-dependent protein kinase IV mediated by ADNF.

in vivo

Colivelin (intracerebroventricular administration; 10 pmol/3 μl; 3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, in addition, it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[1]. Colivelin (intraperitoneal administration; 1.4, 7, or 35 nM/0.21 mL; on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit[1]. Colivelin (intraperitoneal injection; 1 mg/kg; 14 days) results in improved motor and cognitive function with time by performance of mNSS, rotarod, and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO[3].

Animal Model:CD-1 mice[1]
Dosage:10 pmol/3 μl
Administration:Intracerebroventricular administration
Result:Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.
Animal Model:C57 mice[1]
Dosage:1.4, 7, or 35 nM/0.21mL
Administration:Intraperitoneal administration
Result:Protected against cholinotoxin-induced amnesia in mice.
Animal Model: Male C57BL/6 mice[3]
Dosage:1 mg/kg
Administration:Intraperitoneal administration
Result:Protected against ischemic brain injury, and improves neurological outcomes

IC 50

STAT3; Amyloid-β

storage

Store at -20°C

References

[1] TOMOHIRO CHIBA. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer’s disease-relevant insults in vitro and in vivo.[J]. Journal of Neuroscience, 2005, 25 44: 10252-10261. DOI: 10.1523/jneurosci.3348-05.2005
[2] MARINA YAMADA. Nasal Colivelin Treatment Ameliorates Memory Impairment Related to Alzheimer”s Disease[J]. Neuropsychopharmacology, 2007, 33 8: 2020-2032. DOI: 10.1038/sj.npp.1301591
[3] TOMOHIRO CHIBA . Colivelin prolongs survival of an ALS model mouse[J]. Biochemical and biophysical research communications, 2006, 343 3: Pages 793-798. DOI: 10.1016/j.bbrc.2006.02.184

COLIVELIN Preparation Products And Raw materials

Raw materials

Preparation Products

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COLIVELIN Suppliers

China 111 Europe 1 Germany 1 United Kingdom 2 United States 9 Global 124
Creative Peptides
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Email
info@creative-peptides.com
Country
United States
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6083
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56
BOC Sciences
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+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
EBRATOR BIOCHEMICALS,INC.
Tel
--
Fax
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Email
sales@ebtbio.com
Country
United States
ProdList
577
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58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80
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View Lastest Price from COLIVELIN manufacturers

Strong peptide cross-border e-commerce Co. LTD
Product
COLIVELIN 867021-83-8
Price
US $40.00-35.00/box
Min. Order
1box
Purity
99.9+
Supply Ability
2000box
Release date
2024-05-28
Strong peptide cross-border e-commerce Co. LTD
Product
COLIVELIN 867021-83-8
Price
US $40.00-35.00/box
Min. Order
1box
Purity
99.9+
Supply Ability
2000box
Release date
2024-05-28
Strong peptide cross-border e-commerce Co. LTD
Product
COLIVELIN 867021-83-8
Price
US $40.00-35.00/box
Min. Order
1box
Purity
99.9+
Supply Ability
2000box
Release date
2024-05-28

867021-83-8, COLIVELINRelated Search:

Tetanus toxin (830-843) PYR-LEU-THR-PHE-THR-SER-SER-TRP-GLY-NH2 PACAP38 NEUROKININ A L-Leu-Leu-Leu COLIVELIN

  • COLIVELIN
  • H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH
  • Colivelin (human)
  • SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO
  • Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt
  • L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-
  • Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury
  • SALLRSIPAPAGASRLLLLTGEIDLP
  • 867021-83-8
  • C119H206N32O35
  • Amyloid beta-peptide and related