GSK620
- Product Name
- GSK620
- CAS No.
- 2088410-46-0
- Chemical Name
- GSK620
- Synonyms
- GSK620;1-benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide;3,5-Pyridinedicarboxamide, N5-cyclopropyl-1,2-dihydro-N3-methyl-2-oxo-1-(phenylmethyl)-;Inhibitor,oral,GSK 620,phenotype,selectivity,GSK-620,whole,anti-inflammatory,GSK620,Epigenetic Reader Domain,inhibit,human,blood
- CBNumber
- CB48067227
- Molecular Formula
- C18H19N3O3
- Formula Weight
- 325.36
- MOL File
- 2088410-46-0.mol
GSK620 Property
- Boiling point:
- 618.6±55.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 62.5 mg/mL (192.09 mM; Need ultrasonic)
- pka
- 12.43±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-0142650
- Product name
- GSK620
- Purity
- 99.86%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0142650
- Product name
- GSK620
- Purity
- 99.86%
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0142650
- Product name
- GSK620
- Purity
- 99.86%
- Packaging
- 25mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- CS-0142650
- Product name
- GSK620
- Purity
- 99.86%
- Packaging
- 50mg
- Price
- $1450
- Updated
- 2021/12/16
- Product number
- CS-0142650
- Product name
- GSK620
- Purity
- 99.86%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
GSK620 Chemical Properties,Usage,Production
Biological Activity
GSK620 is a potent and orally active pan-BD2 inhibitor with excellent broad selectivity, developability and in vivo oral pharmacokinetics. GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood[1]. GSK620 shows an anti-inflammatory phenotype in human whole blood. Human blood samples are stimulated with LPS, which produces a strong immune response. The monocyte chemattractant protein 1 (MCP-1/CCL2) is measured. This is a chemokine which recruits monocytes, memory T cells, and dendritic cells to sites of inflammation. GSK620 reduces the MCP-1 response in a concentration-dependent manner with (an expected) ～1 log drop off in potency relative to the biochemical BRD4 BD2 potencies observed[1]. Highlighting the utility of GSK620 as an in vivo tool, efficacy is observed in separate models of inflammatory arthritis, psoriasis, and hepatitis[1].
References
[1]. Seal JT, et al. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J Med Chem. 2020;63(17):9093-9126.
GSK620 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK620 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58
View Lastest Price from GSK620 manufacturers
- Product
- GSK620 2088410-46-0
- Price
- US $1.00/box
- Min. Order
- 1box
- Purity
- 98%
- Supply Ability
- 1
- Release date
- 2022-11-19