Urtoxazumab

Product Name: Urtoxazumab
CAS No.: 502496-16-4
Chemical Name: Urtoxazumab
Synonyms: Urtoxazumab;Research Grade Urtoxazumab;Research Grade Urtoxazumab (DXX00501)
CBNumber: CB48080789
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Urtoxazumab Chemical Properties,Usage,Production

Uses

Urtoxazumab (TMA-15) is a humanizedized monoclonal antibody against Shiga toxin (Stx) 2[1].

in vivo

Urtoxazumab (TMA-15) (0.25-2.5 mg/kg; i.v.; once) ameliorates the lethal challenge in a time- and dose- dependent manner in B2F1-infected mice^[1].

Animal Model:	5-week-old male DBA/2J mice, STEC B2F1-infection model^[1]
Dosage:	0.25, 0.5, 1.0, 2.0 and 2.5 mg/kg
Administration:	Intravenous administration, 1 h before and 12, 24, and 48 h after infection
Result:	Pretreatment completely protected the infected mice from death, the efficacy of the low dose (0.25 mg/kg) was partial when administered at 12 and 24 h after infection, but the efficacy of the high dose (2.5 mg/kg) was still complete. Prevented death from B2F1 infection in all 20 animals at 1.0 and 2.0 mg/kg 24 h after infection.

References

[1] Yamagami S, et al. Efficacy of postinfection treatment with anti-Shiga toxin (Stx) 2 humanized monoclonal antibody TMA-15 in mice lethally challenged with Stx-producing Escherichia coli. J Infect Dis. 2001 Sep 15;184(6):738-42. DOI:10.1086/323082

Urtoxazumab Preparation Products And Raw materials

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Urtoxazumab

Research Grade Urtoxazumab (DXX00501)

Research Grade Urtoxazumab

502496-16-4