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Narnatumab

Product Name
Narnatumab
CAS No.
1188275-92-4
Chemical Name
Narnatumab
Synonyms
Narnatumab;Narnatumab (anti-RON);Research Grade Narnatumab;Research Grade Narnatumab(DHG03401)
CBNumber
CB48080840
Formula Weight
0
MOL File
Mol file
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Narnatumab Property

form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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Narnatumab Chemical Properties,Usage,Production

Uses

Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), with a Kd of 32 pM. Narnatumab can be used for the research of cancer[1].

in vivo

Narnatumab (2-60 mg/kg; i.p. every 3 days) shows antitumor activity in non-small cell lung cancer (NSCLC) and bladder cancer models in athymic mice[1].
Narnatumab exhibits terminal half-life (t1/2=5.2 d) and achieves antitumor effects at a steady-state plasma trough level of approximately 140 μg/mL in mice[1].

Animal Model:Female athymic nu/nu mice (6-8 weeks) were injected NCI-H292 and BFTC-905 cells[1]
Dosage:2, 20, 60 mg/kg
Administration:I.p. every 3 days for 36 and 18 days
Result:Inhibited tumor growth in a dose-dependent manner.

References

[1] LoRusso PM, et, al. Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors. Invest New Drugs. 2017 Aug;35(4):442-450. DOI:10.1007/s10637-016-0413-0

Narnatumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Narnatumab Suppliers

China 15 United States 1 Global 16
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd
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15817493340
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981810490@qq.com
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Wuhan Chemstan Biotechnology Co., Ltd.
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027-65317797 15926423062
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Biolab Reagents
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027-65279366 18108604356
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Wuhan Jingkangen Biomedical Technology Co., Ltd
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13720134139 086-15871494362 13720134139
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orders@jknbiochem.com
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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400-6206333 13167063860
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Changsha Fuzhen Biotechnology Co.，LTD
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0731-13823398 15111215862
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313359644@qq.com
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Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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  • Narnatumab
  • Research Grade Narnatumab(DHG03401)
  • Narnatumab (anti-RON)
  • Research Grade Narnatumab
  • 1188275-92-4