ChemicalBook > CAS DataBase List > Teprotumumab
Teprotumumab
- Product Name
- Teprotumumab
- CAS No.
- 1036734-93-6
- Chemical Name
- Teprotumumab
- Synonyms
- Teprotumumab;R 1507|||HZN 001;Teprotumumab (anti-IGF1R);Research Grade Teprotumumab;Research Grade Teprotumumab(DHC29903)
- CBNumber
- CB78080816
- Formula Weight
- 0
- MOL File
- Mol file
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Teprotumumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Teprotumumab Chemical Properties,Usage,Production
Uses
Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].
References
[1] Chen H, et al. Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes. J Clin Endocrinol Metab. 2014 Sep;99(9):E1635-40. DOI:10.1210/jc.2014-1580
Teprotumumab Preparation Products And Raw materials
Raw materials
Preparation Products
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Teprotumumab Suppliers
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- 021-61312847; 18021002903
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