ChemicalBook > CAS DataBase List > Dostarlimab
Dostarlimab
- Product Name
- Dostarlimab
- CAS No.
- 2022215-59-2
- Chemical Name
- Dostarlimab
- Synonyms
- TSR-042;Dostarlimab;Dostarlimab (anti-PD-1);Research Grade Dostarlimab;Research Grade Dostarlimab (DHH02205)
- CBNumber
- CB48081100
- Formula Weight
- 0
- MOL File
- Mol file
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Dostarlimab Property
- form
- Liquid
- color
- Colorless to light yellow
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Dostarlimab Chemical Properties,Usage,Production
Uses
Dostarlimab (TSR-042) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC50s of 1.8 and 1.5 nM, respectively[1].
in vivo
Dostarlimab (200 μg/mouse; i.p.; twice weekly for 35 days) shows antitumor activity in humanized mouse models[1].
| Animal Model: | Humanized NOG-EXL mice, A549 and MDA-MB-436 tumor model[1] |
| Dosage: | 200 μg/mouse |
| Administration: | Intraperitoneal injection; twice weekly for 35 days |
| Result: | Resulted in great inhibition of tumor growth in an A549 lung cancer model (tumor growth inhibition [TGI] of 62% at termination). The antitumor activity was associated with a reduction in tumor-associated regulatory T cells and a trend toward increased tumor-infiltrating CD8+ T cells. Inhibited tumor growth of MDA-MB-436 breast cancer model (TGI of 53%). |
References
[1] Kumar S, et al. Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models. MAbs. 2021 Jan-Dec;13(1):1954136. DOI:10.1080/19420862.2021.1954136
Dostarlimab Preparation Products And Raw materials
Raw materials
Preparation Products
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Dostarlimab Suppliers
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
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