Avdoralimab

Product Name: Avdoralimab
CAS No.: 2226393-85-5
Chemical Name: Avdoralimab
Synonyms: Avdoralimab;Avdoralimab (anti-C5AR1);Research Grade Avdoralimab;Research Grade Avdoralimab (DHD47201)
CBNumber: CB48081160
Formula Weight: 0
MOL File: Mol file

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Avdoralimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Avdoralimab Chemical Properties,Usage,Production

Uses

Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research[1].

in vivo

In mice with a knock in for human C5aR1 (HuC5aR1 KI mice), Avdoralimab blocks the infiltration of neutrophils and monocytes, prevents albumin release in broncho-alveolar lavage fluid (BALF) and limits C5a-induced acute lung injury (ALI) histopathological features^[1].

References

[1] Julien Carvelli, et al. Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis. Nature. 2020 Dec;588(7836):146-150. DOI:10.1038/s41586-020-2600-6

Avdoralimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Avdoralimab Suppliers

China 16 United States 1 Global 17

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2226393-85-5, AvdoralimabRelated Search:

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Avdoralimab

Research Grade Avdoralimab (DHD47201)

Avdoralimab (anti-C5AR1)

Research Grade Avdoralimab

2226393-85-5