Teplizumab

Product Name: Teplizumab
CAS No.: 876387-05-2
Chemical Name: Teplizumab
Synonyms: Teplizumab;PRV-031|||MGA-031;Teplizumab (DHC27703);Teplizumab (anti-CD3e);Research Grade Teplizumab;Research Grade Teplizumab(DHC27703);TeplizumabQ: What is Teplizumab Q: What is the CAS Number of Teplizumab
CBNumber: CB48081201
Formula Weight: 0
MOL File: Mol file

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Teplizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Teplizumab Chemical Properties,Usage,Production

Uses

Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes[1][2].

in vivo

Teplizumab (0.24 mg/kg, i.p.) induces migration of human CD4 T cells to the lamina propria and ablated the treatment effects of the drug on graft survival in NSG mice^[2].

Animal Model:	NOD/SCID IL2γc^-/- (NSG) mice (a tolergenic humanized mouse model)^[1]
Dosage:	0.24 mg/kg, 5 μg
Administration:	Intraperitoneal injection (i.p.)
Result:	Decreased CD4:CD8 ratio in the peripheral blood from 2.03 to 1.01, p < 0.05. Decreased circulating hCD4 cells in the peripheral blood. Decreased in the proportion of T cells in the bone marrow and lung. Increased in the total number of human CD45+ cells infiltrating the lamina propria of the small intestine.

References

[1] Kevan C Herold, et al. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 Aug 15;381(7):603-613. DOI:10.1056/NEJMoa1902226
[2] Frank Waldron-Lynch, et al. I Analysis of FcR non-binding anti-CD3 mAb in humanized mice identifies novel human gut tropic cells with regulatory function that are found in patients. Sci Transl Med. 2012 Jan 25;4(118):118ra12. DOI:10.1126/scitranslmed.3003401
[3] Brygida Bisikirska, et al. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest. 2005 Oct;115(10):2904-13. DOI:10.1172/JCI23961

Teplizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Teplizumab Suppliers

China 19 India 1 United States 1 Global 21

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
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Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
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Country: China
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Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 1566
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Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
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Country: China
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Bide Pharmatech Ltd.

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Email: product02@bidepharm.com
Country: China
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
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Biolab Reagents

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Shanghai Yifei Biotechnology Co. , Ltd.

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Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

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Shanghai Aladdin Biochemical Technology Co.,Ltd.

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Country: China
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876387-05-2, TeplizumabRelated Search:

Suvizumab EFALIZUMABUM Fulranumab Blinatumomab Foravirumab Balstilimab Lebrikizumab palivizumab Stamulumab Leronlimab

Teplizumab

TeplizumabQ: What is Teplizumab Q: What is the CAS Number of Teplizumab

Teplizumab (DHC27703)

Research Grade Teplizumab(DHC27703)

Teplizumab (anti-CD3e)

PRV-031|||MGA-031

Research Grade Teplizumab

876387-05-2