Azido-PEG1-Val-Cit-PAB-OH

Product Name: Azido-PEG1-Val-Cit-PAB-OH
CAS No.: 2055041-40-0
Chemical Name: Azido-PEG1-Val-Cit-PAB-OH
Synonyms: Azido-PEG1-Val-Cit-PAB-OH;Azide-PEG1-Val-Cit-PABC-OH;L-Ornithinamide, N-[3-(2-azidoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
CBNumber: CB48184519
Molecular Formula: C23H36N8O6
Formula Weight: 520.59
MOL File: 2055041-40-0.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23205
Product name: Azido-PEG1-Val-Cit-PAB-OH
Purity: 96%
Packaging: 100mg
Price: $350
Updated: 2021/12/16

BroadPharm

Product number: BP-23205
Product name: Azido-PEG1-Val-Cit-PAB-OH
Purity: 96%
Packaging: 250mg
Price: $560
Updated: 2021/12/16

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Azido-PEG1-Val-Cit-PAB-OH Chemical Properties,Usage,Production

Description

Azido-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.

Uses

Azide-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azide-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Azido-PEG1-Val-Cit-PAB-OH Preparation Products And Raw materials

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Azido-PEG1-Val-Cit-PAB-OH Suppliers

China 16 United States 3 Global 19

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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View Lastest Price from Azido-PEG1-Val-Cit-PAB-OH manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Azido-PEG1-Val-Cit-PAB-OH 2055041-40-0
Price: US $0.00/mg
Min. Order: 250mg
Purity: >95.00%
Supply Ability: 250mg
Release date: 2024-03-29

2055041-40-0, Azido-PEG1-Val-Cit-PAB-OHRelated Search:

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Azido-PEG1-Val-Cit-PAB-OH

Azide-PEG1-Val-Cit-PABC-OH

L-Ornithinamide, N-[3-(2-azidoethoxy)-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

2055041-40-0

ADC LINKER