ChemicalBook > CAS DataBase List > 3-FLUORO-4-NITRO-BENZALDEHYDE
3-FLUORO-4-NITRO-BENZALDEHYDE
- Product Name
- 3-FLUORO-4-NITRO-BENZALDEHYDE
- CAS No.
- 160538-51-2
- Chemical Name
- 3-FLUORO-4-NITRO-BENZALDEHYDE
- Synonyms
- uoro-4-nitrobenzenecarbaL;3-floro-4-nitrobenzaldehyde;2-Fluoro-4-formylnitrobenzene;3-FLUORO-4-NITRO-BENZALDEHYDE;Benzaldehyde, 3-fluoro-4-nitro-;8-(Trifluoromethyl)propiophenone;3-Fluoro-4-nitrobenzaldehyde 98%;3-FLUORO-4-NITROBENZENECARBALDEHYDE
- CBNumber
- CB4836142
- Molecular Formula
- C7H4FNO3
- Formula Weight
- 169.11
- MOL File
- 160538-51-2.mol
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3-FLUORO-4-NITRO-BENZALDEHYDE Property
- Melting point:
- 57-58
- Boiling point:
- 312℃
- Density
- 1.443
- Flash point:
- 143℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- Light yellow to Amber
- InChI
- InChI=1S/C7H4FNO3/c8-6-3-5(4-10)1-2-7(6)9(11)12/h1-4H
- InChIKey
- BWUIGISQVCIQBT-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C([N+]([O-])=O)C(F)=C1
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Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2913000090
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- F1130
- Product name
- 3-Fluoro-4-nitrobenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $83
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F1130
- Product name
- 3-Fluoro-4-nitrobenzaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $326
- Updated
- 2025/07/31
TRC
- Product number
- F401538
- Product name
- 3-Fluoro-4-nitrobenzaldehyde
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0004663
- Product name
- 3-FLUORO-4-NITROBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1766
- Updated
- 2021/12/16
AK Scientific
- Product number
- 8095AA
- Product name
- 3-Fluoro-4-nitrobenzaldehyde
- Packaging
- 25g
- Price
- $381
- Updated
- 2021/12/16
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3-FLUORO-4-NITRO-BENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
3-fluoro-4-nitrobenzaldehyde is a strong, oxidizing agent with a pungent odor that is soluble in organic solvents.
Uses
3-fluoro-4-nitrobenzaldehyde is resistant to oxidation by acids and bases and can be used for the synthesis of cytomegalovirus (CMV) inhibitors.
Synthesis
863604-64-2
160538-51-2
General procedure for the synthesis of 3-fluoro-4-nitrobenzaldehyde from 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide: 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide was added to 800 mL of tetrahydrofuran (THF) under ice-salt/water bath cooling conditions. Subsequently, a THF solution of 1 M diisobutylaluminum hydride (DIBAL) was slowly added through the addition funnel over 30 min. The reaction mixture was stirred under nitrogen (N2) protection for 1 hour. Upon completion of the reaction, the reaction mixture was carefully diluted with 1N hydrochloric acid (500 mL) and ethyl acetate (EtOAc, 500 mL) and then transferred to a separatory funnel for separation. The organic phase was washed sequentially with 1N hydrochloric acid (3 × 250 mL), 1N sodium hydroxide (2 × 250 mL) and water (250 mL). All aqueous layers were back-extracted with ethyl acetate (2 × 250 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated in vacuum to give 67 g of the target product 3-fluoro-4-nitrobenzaldehyde (396 mmol, 88% yield). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H-NMR, DMSO-d6): δ 10.06 (s, 1H), 8.36-8.32 (t, J = 7.8 Hz, 1H), 8.06-8.03 (d, J = 11.2 Hz, 1H), 7.95-7.93 (d, J = 9.1 Hz, 1H).
References
[1] Patent: WO2005/121147, 2005, A1. Location in patent: Page/Page column 106
3-FLUORO-4-NITRO-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-NITRO-BENZALDEHYDE manufacturers
Career Henan Chemical Co
- Product
- 3-FLUORO-4-NITRO-BENZALDEHYDE 160538-51-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24
160538-51-2, 3-FLUORO-4-NITRO-BENZALDEHYDERelated Search:
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