alpha-yohimbine
- Product Name
- alpha-yohimbine
- CAS No.
- 131-03-3
- Chemical Name
- alpha-yohimbine
- Synonyms
- α-Yohimbine;Methyl (16?,17?,20?)-17-hydroxyyohimban-16-carboxylate;methyl17α-hydroxy-20α-yohimban-16β-carboxylate(α-yohimbine);4-(2-amino-1-hydroxyethyl)-2-methoxyphenol hydrochloride(1:1);methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate;Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, (16b,17a,20a)-;Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16β,17α,20α)-
- CBNumber
- CB4874933
- Molecular Formula
- C21H26N2O3
- Formula Weight
- 354.44
- MOL File
- 131-03-3.mol
alpha-yohimbine Property
- Melting point:
- 243-244°
- alpha
- D19 -18° (pyridine); D19 -27° (abs alcohol)
- Boiling point:
- 543.0±50.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- pka
- 6.34(at 25℃)
- form
- Solid
- color
- Light yellow to brown
Safety
- RIDADR
- 1544
- HazardClass
- 6.1(a)
- PackingGroup
- II
N-Bromosuccinimide Price
- Product number
- W1076
- Product name
- alpha-Yohimbine
- Packaging
- 1mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- API0009297
- Product name
- RAUWOLSCINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.64
- Updated
- 2021/12/16
- Product number
- CFN99400
- Product name
- alpha-Yohimbine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $373
- Updated
- 2021/12/16
alpha-yohimbine Chemical Properties,Usage,Production
Uses
Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1].
Definition
ChEBI: Rauwolscine is a methyl 17-hydroxy-20xi-yohimban-16-carboxylate.
in vivo
Rauwolscine (0.5 mg/kg, daily) reduces tumor growth by enhancing apoptosis and reducing cell proliferation in Balb/c female virgin mice[1].
Rauwolscine (i.v., 2.24 mg/kg) can significantly release lick-shock conflict responding in rats similar to the α agonist clonidine (0.022 mg/kg) and the benzodiazepine diazepam (0.5 mg/kg) [2].
References
[1] A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155(4):494-504. DOI:10.1038/bjp.2008.278
[2] S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54(10):PL179-84. DOI:10.1016/0024-3205(94)00556-7
alpha-yohimbine Preparation Products And Raw materials
Raw materials
Preparation Products
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