alpha-ethoxy-p-cresol
- Product Name
- alpha-ethoxy-p-cresol
- CAS No.
- 57726-26-8
- Chemical Name
- alpha-ethoxy-p-cresol
- Synonyms
- alpha-Ethoxy-p-creso;4-Ethoxymethylphenol;alpha-ethoxy-p-cresol;4-(Ethoxymethyl)phenol;p-Hydroxybenzyl Et ether;Phenol, 4-(ethoxymethyl)-;4-hydroxybenzyl ethyl ether;p-Hydroxybenzyl ethyl ether;4-(Ethoxymethyl)phenol, 10 mM in DMSO
- CBNumber
- CB4890739
- Molecular Formula
- C9H12O2
- Formula Weight
- 152.19
- MOL File
- 57726-26-8.mol
alpha-ethoxy-p-cresol Property
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- color
- White to off-white
- LogP
- 1.699 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E939573
- Product name
- 4-(Ethoxymethyl)phenol
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- MTB0000983
- Product name
- 4-(ETHOXYMETHYL)PHENOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.42
- Updated
- 2021/12/16
- Product number
- 119865
- Product name
- 4-(Ethoxymethyl)phenol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $706
- Updated
- 2021/12/16
- Product number
- Z4904
- Product name
- 4-(Ethoxymethyl)phenol
- Packaging
- 1g
- Price
- $771
- Updated
- 2021/12/16
- Product number
- 119865
- Product name
- 4-(Ethoxymethyl)phenol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1764
- Updated
- 2021/12/16
alpha-ethoxy-p-cresol Chemical Properties,Usage,Production
Uses
4-(Ethoxymethyl)phenol (p-Hydroxybenzyl Et ether) is a potent antioxidant from Amburana cearensis leaf extract, with in vitro cytogenotoxic properties. Amburana cearensis leaves can be used foe the research of respiratory diseases and inflammations[1].
Definition
ChEBI: 4-(Ethoxymethyl)phenol is a benzyl ether.
Synthesis
64-17-5
623-05-2
57726-26-8
General procedure for the synthesis of 4-(ethoxymethyl)phenol from ethanol and p-hydroxybenzyl alcohol: refer to the operation of Example 2, but substitute ethanol for methanol. After completion of the reaction, the residue was purified by reduced pressure distillation (boiling point: 110-119°C/1.5 Torr) to obtain 4-ethoxymethylphenol in 75% yield and 98% HPLC purity. The operation was as follows: in a 200 mL three-necked flask equipped with a thermometer, a three-way stopper and a stirrer, 15.0 g (0.12 mol) of p-hydroxybenzyl alcohol and 69 g of ethanol were added under nitrogen protection, followed by 0.06 g of nitromethane. A mixed solution consisting of 0.45 g of hydrochloric acid and 3.0 g of ethanol was slowly added dropwise under stirring at room temperature, and then the reaction mixture was stirred at 35 °C for 3 hours. At the end of the reaction, HPLC analysis showed an area percentage of 99%. Next, a mixed solution comprising 0.38 g of imidazole (manufactured by Aldrich Co., Ltd.) and 1.1 g of ethanol was added dropwise for neutralization, followed by concentration under reduced pressure to remove ethanol. To the concentrate, 60 g of isopropyl ether (produced by Nacalai Tesque, Inc.) and 22.5 g of water were added and the organic layer was further washed with 27 g of water and 0.26 g of acetic acid (produced by Nacalai Tesque). After washing the organic layer twice with water, the organic layer was concentrated, the crystal seed was added and slowly cooled to about 8°C. The precipitated crystals were filtered and dried to give 12.0 g (yield: 72%) of colorless 4-methoxymethylphenol with 99% HPLC purity.
References
[1] José Rafael da Silva Araujo, et al. Antioxidant and in vitro cytogenotoxic properties of Amburana cearensis (Allemo) A.C.Sm. leaf extract. Drug Chem Toxicol. 2021 Dec 14;1-9. DOI:10.1080/01480545.2021.2011313
alpha-ethoxy-p-cresol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from alpha-ethoxy-p-cresol manufacturers
- Product
- 4-(Ethoxymethyl)phenol 57726-26-8
- Price
- US $590.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-04-11