cGAMP disodium
- Product Name
- cGAMP disodium
- CAS No.
- 2407516-83-8
- Chemical Name
- cGAMP disodium
- Synonyms
- cGAMP disodium;3',3'-cGAMP disodium;3',3'-cGAMP disodium);cGAMP disodium (Cyclic GMP-AMP disodium
- CBNumber
- CB49272783
- Molecular Formula
- C20H25N10NaO13P2
- Formula Weight
- 698.41
- MOL File
- 2407516-83-8.mol
cGAMP disodium Property
- storage temp.
- Store at -20°C
- solubility
- Water: 10 mM
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble to 10 mM in water
cGAMP disodium Chemical Properties,Usage,Production
Uses
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
Biological Activity
cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions[1][2].
in vivo
cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].
| Animal Model: | Female C57BL/6 (H-2b) mice 6-8 weeks old[2] |
| Dosage: | 5 μg |
| Administration: | Nostril mucosal adjuvant |
| Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |
IC 50
Human Endogenous Metabolite
storage
Store at -20°C
References
[1] Wright TA, et al. Second messengers and divergent HD - GYP phosphodiesterases regulate 3’,3’ - cGAMP signaling. Mol Microbiol. 2020;113(1):222 - 236.
[2] BRYAN W DAVIES. Coordinated regulation of accessory genetic elements produces cyclic di - nucleotides for V. cholerae virulence.[J]. Cell, 2012, 149 2: 358 - 370. DOI: 10.1016/j.cell.2012.01.053
[3] XU ZHANG. Cyclic GMP - AMP containing mixed phosphodiester linkages is an endogenous high - affinity ligand for STING.[J]. Molecular Cell, 2013, 51 2: 226 - 235. DOI: 10.1016/j.molcel.2013.05.022
cGAMP disodium Preparation Products And Raw materials
Raw materials
Preparation Products
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