rotundine
- Product Name
- rotundine
- CAS No.
- 483-14-7
- Chemical Name
- rotundine
- Synonyms
- Hyndarine;Gindarine;(-)-Gindarine;ROTUNDINE 98+%;ROTUNDINE (RG);Rotundine?, BR;(S)-Tetrahydrop;Rafoxanide Impurity 3;(S)-Tetrahydropalmitine;(-)-S-TetrahydropalMatine
- CBNumber
- CB4947141
- Molecular Formula
- C21H25NO4
- Formula Weight
- 355.43
- MOL File
- 483-14-7.mol
rotundine Property
- Melting point:
- 141-143°C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- insoluble in H2O; ≥16 mg/mL in DMSO; ≥2.95 mg/mL in EtOH with gentle warming and ultrasonic
- Boiling point:
- 482.9±45.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- pka
- 6.53±0.20(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- λmax
- 280nm(lit.)
- CAS DataBase Reference
- 483-14-7
Safety
- RTECS
- HQ1792500
- HS Code
- 2933.99.9000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- T3311
- Product name
- L-Tetrahydropalmatine
- Purity
- >98.0%(HPLC)
- Packaging
- 250mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $78
- Updated
- 2024/03/01
rotundine Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Rotundine is an analgesic drug found in Chinese herbal medicine, used to treat heart disease and liver damage.
Definition
ChEBI: A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.
Biological Activity
levo-tetrahydropalmatine (l-thp) is an active herbal constituent of preparations containing plant species of the genera stephania and corydalis. in china, it has been approved and used for a number of clinical indications under the drug name rotundine.
in vitro
in contrast to other thpb derivatives, l-thp is an antagonist at both of d1 and d2 receptors. the ki values for l-thp at d1 and d2 dopamine receptors are approximately 124 nm (d1) and 388 nm (d2), while the ic50 values are 166 nm and 1.4 μm for d1 and d2, respectively. the relatively high affinity of l-thp at d1 vs. d2 receptors, distinguishes it from other available dopamine receptor antagonist drugs (e.g., haloperidol) [1].
in vivo
it has been found that l-thp produces dose-dependent reductions in locomotor activity and operant responding for non-drug reinforcers in rats [1].
References
[1] wang jb, mantsch jr. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. future med chem. 2012 feb;4(2):177-86.
rotundine Preparation Products And Raw materials
Raw materials
Preparation Products
rotundine Suppliers
View Lastest Price from rotundine manufacturers
- Product
- L-Tetrahydropalmatine 483-14-7
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-12-03
- Product
- L-Tetrahydropalmatine 483-14-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- rotundine 483-14-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-01-09