ChemicalBook > CAS DataBase List > rotundine
rotundine
- Product Name
- rotundine
- CAS No.
- 483-14-7
- Chemical Name
- rotundine
- Synonyms
- Hyndarine;Gindarine;(-)-Gindarine;ROTUNDINE 98+%;ROTUNDINE (RG);Rotundine?, BR;(S)-Tetrahydrop;Rafoxanide Impurity 3;(S)-Tetrahydropalmitine;(-)-S-TetrahydropalMatine
- CBNumber
- CB4947141
- Molecular Formula
- C21H25NO4
- Formula Weight
- 355.43
- MOL File
- 483-14-7.mol
More
Less
rotundine Property
- Melting point:
- 141-143°C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- insoluble in H2O; ≥16 mg/mL in DMSO; ≥2.95 mg/mL in EtOH with gentle warming and ultrasonic
- Boiling point:
- 482.9±45.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- pka
- 6.53±0.20(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- λmax
- 280nm(lit.)
- CAS DataBase Reference
- 483-14-7
More
Less
Safety
- RTECS
- HQ1792500
- HS Code
- 2933.99.9000
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
More
Less
N-Bromosuccinimide Price
TCI Chemical
- Product number
- T3311
- Product name
- L-Tetrahydropalmatine
- Purity
- >98.0%(HPLC)
- Packaging
- 250mg
- Price
- $89
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $48
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $63
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20535
- Product name
- L-Tetrahydropalmatine
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $78
- Updated
- 2024/03/01
More
Less
rotundine Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Rotundine is an analgesic drug found in Chinese herbal medicine, used to treat heart disease and liver damage.
Definition
ChEBI: A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.
Biological Activity
levo-tetrahydropalmatine (l-thp) is an active herbal constituent of preparations containing plant species of the genera stephania and corydalis. in china, it has been approved and used for a number of clinical indications under the drug name rotundine.
in vitro
in contrast to other thpb derivatives, l-thp is an antagonist at both of d1 and d2 receptors. the ki values for l-thp at d1 and d2 dopamine receptors are approximately 124 nm (d1) and 388 nm (d2), while the ic50 values are 166 nm and 1.4 μm for d1 and d2, respectively. the relatively high affinity of l-thp at d1 vs. d2 receptors, distinguishes it from other available dopamine receptor antagonist drugs (e.g., haloperidol) [1].
in vivo
it has been found that l-thp produces dose-dependent reductions in locomotor activity and operant responding for non-drug reinforcers in rats [1].
References
[1] wang jb, mantsch jr. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. future med chem. 2012 feb;4(2):177-86.
rotundine Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
rotundine Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94838
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 0757-86329057 18501085097
- Fax
- 010-89508210
- sales3.gd@hwrkchemical.com
- Country
- China
- ProdList
- 7639
- Advantage
- 55
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- +8613162137806 18575662672
- Fax
- 021 51613951
- mzeng@3wpharm.com
- Country
- China
- ProdList
- 9747
- Advantage
- 57
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5654
- Advantage
- 65
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 86-13605431940 13605431940
- Fax
- 0086-0543-2240079
- zpmxchemical@126.com
- Country
- China
- ProdList
- 2002
- Advantage
- 62
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9636
- Advantage
- 58
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14623
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 028-85370565-229 18080489829
- 3004654993@qq.com
- Country
- China
- ProdList
- 9176
- Advantage
- 60
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28821
- Advantage
- 58
- Tel
- 021-021-52271985 17721149837
- Fax
- +86 (21) 52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 19806
- Advantage
- 60
- Tel
- 028-85142057, 18030712385
- Fax
- 028-85142057 QQ:3591697873
- sales@alfabiotech.com
- Country
- China
- ProdList
- 1925
- Advantage
- 58
- Tel
- 028-88203606; 18283602253
- jancyzheng@gcgreenpure.com
- Country
- China
- ProdList
- 1587
- Advantage
- 58
- Tel
- 86-21-50801717-301
- Fax
- 86-21-50800509
- wangjh@sirc-tcm.sh.cn
- Country
- China
- ProdList
- 2070
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 025-025-51191215 18013836722
- Fax
- 025-51191215
- 2399235533@qq.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- 025-66110311 13155353615
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15527
- Advantage
- 58
- Tel
- +86-27-87465837 +8618971612321
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9635
- Advantage
- 58
- Tel
- 755-36694831 +8613798234863
- Linda.zhou@debayer.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19994
- Advantage
- 58
- Tel
- +8613367258412
- Fax
- 18062427325
- ada@ipurechemical.com
- Country
- China
- ProdList
- 10326
- Advantage
- 58
- Tel
- +86-27-8439 4403 18971486879
- Fax
- +86-27-8439 4403
- sales@chemnorm.com
- Country
- CHINA
- ProdList
- 2935
- Advantage
- 58
- Tel
- +86-13806087780
- sale@simagchem.com
- Country
- China
- ProdList
- 17367
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28180
- Advantage
- 58
- Tel
- 18502101150
- Fax
- +86-21-57127007-6606
- ft-sales@nature-standard.com
- Country
- CHINA
- ProdList
- 1923
- Advantage
- 58
- Tel
- 021-54721350 13524668266
- Fax
- 021-5
- 2881505714@qq.com
- Country
- China
- ProdList
- 7878
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29826
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 027-027-59212684 19107121455
- Fax
- QQ:2188308251
- p19107121455@163.com
- Country
- China
- ProdList
- 1839
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58
- Tel
- 15882229804
- 2851503753@qq.com
- Country
- China
- ProdList
- 2335
- Advantage
- 58
- Tel
- 021-57763112 13585886131
- 3004987436@qq.com
- Country
- China
- ProdList
- 9694
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14092
- Advantage
- 58
- Tel
- 18971486879
- 279414929@qq.com
- Country
- CHINA
- ProdList
- 2925
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9215
- Advantage
- 58
- Tel
- 021-57886085 17317861055
- shhebio@126.com
- Country
- CHINA
- ProdList
- 7975
- Advantage
- 58
- Tel
- 0371-0371-55135753 18003832934
- Fax
- QQ：2853979818
- 2853979818@qq.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58
- Tel
- 028-85159085
- info@aktinchem.com
- Country
- China
- ProdList
- 1676
- Advantage
- 58
More
Less
View Lastest Price from rotundine manufacturers
Shanghai Standard Technology Co., Ltd.
- Product
- L-Tetrahydropalmatine 483-14-7
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-12-03
Honest Joy Holdings Limited
- Product
- L-Tetrahydropalmatine 483-14-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
Career Henan Chemical Co
- Product
- rotundine 483-14-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-01-09
483-14-7, rotundine Related Search:
Sodium levothyroxine pentahydrate
2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one
L-Hyoscyamine
daurisoline
VERATRIDINE
Daurinoline
Xanthiazone
menisdaurin
VERATRINE
Xanthiside
veratramine
alpha,alpha-Diphenyl-4-piperidinomethanol
Desonide
BETONICINE
(S)-Amlodipine
Rotundine
rotundine
13aalpha-Berbin-1-ol, 2,3,9,10-tetramethoxy- (8CI)