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rotundine

Product Name
rotundine
CAS No.
483-14-7
Chemical Name
rotundine
Synonyms
Hyndarine;Gindarine;(-)-Gindarine;ROTUNDINE 98+%;ROTUNDINE (RG);Rotundine?, BR;(S)-Tetrahydrop;Rafoxanide Impurity 3;(S)-Tetrahydropalmitine;Rotundine, 10 mM in DMSO
CBNumber
CB4947141
Molecular Formula
C21H25NO4
Formula Weight
355.43
MOL File
483-14-7.mol
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rotundine Property

Melting point:
141-143°C
storage temp. 
Sealed in dry,2-8°C
solubility 
insoluble in H2O; ≥16 mg/mL in DMSO; ≥2.95 mg/mL in EtOH with gentle warming and ultrasonic
Boiling point:
482.9±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
pka
6.53±0.20(Predicted)
form 
powder to crystal
color 
White to Light yellow
λmax
280nm(lit.)
CAS DataBase Reference
483-14-7
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Safety

RTECS 
HQ1792500
HS Code 
2933.99.9000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3311
Product name
L-Tetrahydropalmatine
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
20535
Product name
L-Tetrahydropalmatine
Purity
≥98%
Packaging
25mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20535
Product name
L-Tetrahydropalmatine
Purity
≥98%
Packaging
50mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
20535
Product name
L-Tetrahydropalmatine
Purity
≥98%
Packaging
100mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
20535
Product name
L-Tetrahydropalmatine
Purity
≥98%
Packaging
250mg
Price
$78
Updated
2024/03/01
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rotundine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Rotundine is an analgesic drug found in Chinese herbal medicine, used to treat heart disease and liver damage.

Definition

ChEBI: A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.

Biological Activity

levo-tetrahydropalmatine (l-thp) is an active herbal constituent of preparations containing plant species of the genera stephania and corydalis. in china, it has been approved and used for a number of clinical indications under the drug name rotundine.

in vitro

in contrast to other thpb derivatives, l-thp is an antagonist at both of d1 and d2 receptors. the ki values for l-thp at d1 and d2 dopamine receptors are approximately 124 nm (d1) and 388 nm (d2), while the ic50 values are 166 nm and 1.4 μm for d1 and d2, respectively. the relatively high affinity of l-thp at d1 vs. d2 receptors, distinguishes it from other available dopamine receptor antagonist drugs (e.g., haloperidol) [1].

in vivo

it has been found that l-thp produces dose-dependent reductions in locomotor activity and operant responding for non-drug reinforcers in rats [1].

References

[1] wang jb, mantsch jr. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. future med chem. 2012 feb;4(2):177-86.

rotundine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from rotundine manufacturers

Shanghai Standard Technology Co., Ltd.
Product
L-Tetrahydropalmatine 483-14-7
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-12-03
Honest Joy Holdings Limited
Product
L-Tetrahydropalmatine 483-14-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99.5%
Supply Ability
100 tons
Release date
2022-02-18
Career Henan Chemical Co
Product
rotundine 483-14-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10 tons
Release date
2020-01-09

483-14-7, rotundine Related Search:

Sodium levothyroxine pentahydrate 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one L-Hyoscyamine daurisoline VERATRIDINE Daurinoline Xanthiazone menisdaurin VERATRINE Xanthiside veratramine alpha,alpha-Diphenyl-4-piperidinomethanol Desonide BETONICINE (S)-Amlodipine Rotundine rotundine 13aalpha-Berbin-1-ol, 2,3,9,10-tetramethoxy- (8CI)

  • 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)-
  • ROTUNDINE 98+%
  • (-)-Gindarine
  • (13aS)-2,3,9,10-Tetramethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quinolizine
  • (S)-Tetrahydropalmitine
  • [13aS,(-)]-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine
  • Gindarine
  • (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
  • TETRAHYDROPALMATINE, L-(P)
  • (-)-S-TetrahydropalMatine
  • (S)-Tetrahydrop
  • O,O-DiMethyl-N-deMethyl-cyclanoline
  • Hyndarine
  • ROTUNDINE (RG)
  • Rotundine?, BR
  • (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine
  • (S)-2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline
  • Rafoxanide Impurity 3
  • Rotundine, 10 mM in DMSO
  • 483-14-7
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors