6-Ethynyl-4,4-dimethylthiochroman

Product Name: 6-Ethynyl-4,4-dimethylthiochroman
CAS No.: 118292-06-1
Chemical Name: 6-Ethynyl-4,4-dimethylthiochroman
Synonyms: Tazarotene Impurity;Tazarotene Impurity 5;Tazarotene Impurity 4;4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN;6-Ethynyl-4,4-dimethyl-thiochroman;4,4-Dimethyl-6-ethynyl-benzothiopyran;6-Ethynyl-4,4-dimethylthiochroman - [E56888];6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene;6-ethynyl-4,4-diMethyl-3,4-dihydro-2H-1-benzothiopyran;6-Ethynyl-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran
CBNumber: CB4948300
Molecular Formula: C13H14S
Formula Weight: 202.32
MOL File: 118292-06-1.mol

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6-Ethynyl-4,4-dimethylthiochroman Property

Melting point:: 69-72 °C
Boiling point:: 299 °C
Density: 1.09
Flash point:: 128 °C
storage temp.: 2-8°C
Appearance: Light yellow to orange Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E932193
Product name: 6-Ethynyl-4,4-dimethylthiochroman
Packaging: 250mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E932193
Product name: 6-Ethynyl-4,4-dimethylthiochroman
Packaging: 1g
Price: $65
Updated: 2021/12/16

Synthonix

Product number: E56888
Product name: 6-Ethynyl-4,4-dimethylthiochroman
Purity: 98%
Packaging: 250mg
Price: $20
Updated: 2021/12/16

Synthonix

Product number: E56888
Product name: 6-Ethynyl-4,4-dimethylthiochroman
Purity: 98%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 091202
Product name: 6-Ethynyl-4,4-dimethylthiochroman
Purity: 95+%
Packaging: 250mg
Price: $189
Updated: 2021/12/16

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6-Ethynyl-4,4-dimethylthiochroman Chemical Properties,Usage,Production

Uses

6-Ethynyl-4,4-dimethylthiochroman is used in preparation of Alkynyl Aryl Iodides via Copper-catalyzed three-component Carboiodination of Arynes.

Synthesis

864841-55-4

118292-06-1

The general procedure for the synthesis of 6-alkynyl-4,4-dimethyldihydrochroman using the compound (CAS: 864841-55-4) as starting material is as follows: Example 4: Preparation of 4,4-dimethyl-6-ethynylthiobenzodihydropyran (2) from compound (8) 1. compound (8) (10.0 g, 45.87 mmol) was dissolved in N,N-dimethylformamide (150 mL) and the reaction system was subsequently cooled to -20°C. 2. Phosphorus trichloride (4.0 mL, 45.87 mmol) was slowly added under stirring and the reaction was continuously stirred for 1 hour. 3. Upon completion of the reaction, the crude product was diluted with ethyl acetate (200 mL) and washed sequentially with saturated sodium chloride solution and deionized water. 4. The organic phase was separated, dried over anhydrous sodium sulfate, filtered and concentrated, and the solvent was removed by vacuum evaporation. 5. The solid obtained was purified by column chromatography with an eluent ratio of hexane/ethyl acetate=9:1, resulting in 7.88 g of the target product (85% yield; oil). Product characterization data: 1H NMR (250 MHz, CDCl3) δ 1.35 (6H, s), 1.95 (2H, m), 3.05 (2H, m), 3.15 (1H, s), 7.13 (1H, d, J = 8.6 Hz), 7.58 (1H, dd, J = 8.6, 2.0 Hz), 7.99 (1H, d, J = 2.0 Hz).

References

[1] Patent: US2006/205950, 2006, A1. Location in patent: Page/Page column 4
[2] Patent: EP1700855, 2006, A1. Location in patent: Page/Page column 6

6-Ethynyl-4,4-dimethylthiochroman Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Ethynyl-4,4-dimethylthiochroman manufacturers

Hangzhou Verychem Science And Technology Co.Ltd

Product: 6-Ethynyl-4,4-dimethylthiochroman 118292-06-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1 tons
Release date: 2025-08-12

Henan Aochuang Chemical Co.,Ltd.

Product: 6-Ethynyl-4,4-dimethylthiochroman 118292-06-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Career Henan Chemical Co

Product: 6-Ethynyl-4,4-dimethylthiochroman 118292-06-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

118292-06-1, 6-Ethynyl-4,4-dimethylthiochromanRelated Search:

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6-Ethynyl-4,4-dimethyl-thiochroman

4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN

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6-ethynyl-4,4-diMethyl-3,4-dihydro-2H-1-benzothiopyran

2H-1-Benzothiopyran,6-ethynyl-3,4-dihydro-4,4-diMethyl-

Tazarotene IMpurity (6-Ethynyl-4,4-DiMethyl ThiochroMan)

Tazarotene Impurity 5

6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene

Tazarotene Impurity 4

Tazarotene Impurity

4,4-Dimethyl-6-ethynyl-benzothiopyran

6-Ethynyl-4,4-dimethylthiochroman - [E56888]

118292-06-1

C13H14S

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