ChemicalBook > CAS DataBase List > 6-Ethynyl-4,4-dimethylthiochroman

6-Ethynyl-4,4-dimethylthiochroman

Product Name
6-Ethynyl-4,4-dimethylthiochroman
CAS No.
118292-06-1
Chemical Name
6-Ethynyl-4,4-dimethylthiochroman
Synonyms
Tazarotene Impurity;Tazarotene Impurity 5;Tazarotene Impurity 4;4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN;6-Ethynyl-4,4-dimethyl-thiochroman;4,4-Dimethyl-6-ethynyl-benzothiopyran;6-Ethynyl-4,4-dimethylthiochroman - [E56888];6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene;6-ethynyl-4,4-diMethyl-3,4-dihydro-2H-1-benzothiopyran;6-Ethynyl-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran
CBNumber
CB4948300
Molecular Formula
C13H14S
Formula Weight
202.32
MOL File
118292-06-1.mol
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6-Ethynyl-4,4-dimethylthiochroman Property

Melting point:
69-72 °C
Boiling point:
299 °C
Density 
1.09
Flash point:
128 °C
storage temp. 
2-8°C
Appearance
Light yellow to orange Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E932193
Product name
6-Ethynyl-4,4-dimethylthiochroman
Packaging
250mg
Price
$45
Updated
2021/12/16
TRC
Product number
E932193
Product name
6-Ethynyl-4,4-dimethylthiochroman
Packaging
1g
Price
$65
Updated
2021/12/16
Synthonix
Product number
E56888
Product name
6-Ethynyl-4,4-dimethylthiochroman
Purity
98%
Packaging
250mg
Price
$20
Updated
2021/12/16
Synthonix
Product number
E56888
Product name
6-Ethynyl-4,4-dimethylthiochroman
Purity
98%
Packaging
1g
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
091202
Product name
6-Ethynyl-4,4-dimethylthiochroman
Purity
95+%
Packaging
250mg
Price
$189
Updated
2021/12/16
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6-Ethynyl-4,4-dimethylthiochroman Chemical Properties,Usage,Production

Uses

6-Ethynyl-4,4-dimethylthiochroman is used in preparation of Alkynyl Aryl Iodides via Copper-catalyzed three-component Carboiodination of Arynes.

Synthesis

864841-55-4

118292-06-1

The general procedure for the synthesis of 6-alkynyl-4,4-dimethyldihydrochroman using the compound (CAS: 864841-55-4) as starting material is as follows: Example 4: Preparation of 4,4-dimethyl-6-ethynylthiobenzodihydropyran (2) from compound (8) 1. compound (8) (10.0 g, 45.87 mmol) was dissolved in N,N-dimethylformamide (150 mL) and the reaction system was subsequently cooled to -20°C. 2. Phosphorus trichloride (4.0 mL, 45.87 mmol) was slowly added under stirring and the reaction was continuously stirred for 1 hour. 3. Upon completion of the reaction, the crude product was diluted with ethyl acetate (200 mL) and washed sequentially with saturated sodium chloride solution and deionized water. 4. The organic phase was separated, dried over anhydrous sodium sulfate, filtered and concentrated, and the solvent was removed by vacuum evaporation. 5. The solid obtained was purified by column chromatography with an eluent ratio of hexane/ethyl acetate=9:1, resulting in 7.88 g of the target product (85% yield; oil). Product characterization data: 1H NMR (250 MHz, CDCl3) δ 1.35 (6H, s), 1.95 (2H, m), 3.05 (2H, m), 3.15 (1H, s), 7.13 (1H, d, J = 8.6 Hz), 7.58 (1H, dd, J = 8.6, 2.0 Hz), 7.99 (1H, d, J = 2.0 Hz).

References

[1] Patent: US2006/205950, 2006, A1. Location in patent: Page/Page column 4
[2] Patent: EP1700855, 2006, A1. Location in patent: Page/Page column 6

6-Ethynyl-4,4-dimethylthiochroman Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Ethynyl-4,4-dimethylthiochroman manufacturers

Hangzhou Verychem Science And Technology Co.Ltd
Product
6-Ethynyl-4,4-dimethylthiochroman 118292-06-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1 tons
Release date
2025-08-12
Henan Aochuang Chemical Co.,Ltd.
Product
6-Ethynyl-4,4-dimethylthiochroman 118292-06-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemical Co
Product
6-Ethynyl-4,4-dimethylthiochroman 118292-06-1
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-22

118292-06-1, 6-Ethynyl-4,4-dimethylthiochromanRelated Search:

Dimethyl sulfoxide Dimethyl ether Dimethyl carbonate ETHANE Dimethyl phthalate N,N-Dimethylformamide Dimethyl fumarate Dimethyl sulfate Hydrochlorothiazide Dacthal Dimethyl disulfide 2-TERT-BUTYLTHIOPHENOL Tazarotene 3-Ethynyltoluene 4,4-DIMETHYL-THIOCHROMAN 6-Ethynyl-4,4-dimethylthiochroman 6-(4,4-DIMETHYL-THIOCHROMAN-6-YLETHYNYL)-NICOTINIC ACID

  • 6-Ethynyl-4,4-dimethyl-thiochroman
  • 4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN
  • 6-Ethynyl-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran
  • 6-ethynyl-4,4-diMethyl-3,4-dihydro-2H-1-benzothiopyran
  • 2H-1-Benzothiopyran,6-ethynyl-3,4-dihydro-4,4-diMethyl-
  • Tazarotene IMpurity (6-Ethynyl-4,4-DiMethyl ThiochroMan)
  • Tazarotene Impurity 5
  • 6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene
  • Tazarotene Impurity 4
  • Tazarotene Impurity
  • 4,4-Dimethyl-6-ethynyl-benzothiopyran
  • 6-Ethynyl-4,4-dimethylthiochroman - [E56888]
  • 118292-06-1
  • C13H14S
  • Pharmaceutical Intermediates