3-AMINO-5-BROMOBENZOIC ACID
- Product Name
- 3-AMINO-5-BROMOBENZOIC ACID
- CAS No.
- 42237-85-4
- Chemical Name
- 3-AMINO-5-BROMOBENZOIC ACID
- Synonyms
- 3-Amino-6-bromobenzoic acid;Benzoicacid,3-aMino-5-broMo-;3-AMINO-5-BROMOBENZOIC ACID USP/EP/BP
- CBNumber
- CB4972327
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 42237-85-4.mol
3-AMINO-5-BROMOBENZOIC ACID Property
- Melting point:
- 217-221 °C
- Boiling point:
- 398.3±32.0 °C(Predicted)
- Density
- 1.793
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 3.97±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H6BrNO2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3H,9H2,(H,10,11)
- InChIKey
- RQSXRGSPGHZKFT-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Br)=CC(N)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 686425
- Product name
- 3-Amino-5-bromobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $210
- Updated
- 2025/07/31
- Product number
- A602473
- Product name
- 3-Amino-5-bromobenzoic acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 127738
- Product name
- 3-Amino-5-bromobenzoic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- CS-W002536
- Product name
- 3-Amino-5-bromobenzoic acid
- Purity
- 98.64%
- Packaging
- 25g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- FA55299
- Product name
- 3-Amino-5-bromobenzoic acid
- Packaging
- 10g
- Price
- $85
- Updated
- 2021/12/16
3-AMINO-5-BROMOBENZOIC ACID Chemical Properties,Usage,Production
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
6307-83-1
42237-85-4
The general procedure for the synthesis of 3-amino-5-bromobenzoic acid from 3-bromo-5-nitrobenzoic acid was as follows: concentrated hydrochloric acid (30 mL) was slowly added to a solution containing 3-bromo-5-nitrobenzoic acid (7.02 g, 28.54 mmol) and ethanol (150 mL), and the mixture was stirred for 5 min at room temperature. Subsequently, tin (II) chloride was added and the reaction mixture was stirred at 50 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature. The pH was adjusted to 9 with 8 M sodium hydroxide solution, at which point a solid precipitated. The solids were removed by filtration. The filtrate was acidified to pH 5 with hydrochloric acid and the target product 3-amino-5-bromobenzoic acid was precipitated, which was filtered to give 5.8 g (94% yield). The product was analyzed by HPLC/MS with a retention time of 4.67 min, LRMS: m/z 216 (M-1).
References
[1] Patent: EP2196465, 2010, A1. Location in patent: Page/Page column 42; 43
[2] Patent: EP2394998, 2011, A1. Location in patent: Page/Page column 22-23
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10479 - 10497
[4] Justus Liebigs Annalen der Chemie, 1884, vol. 222, p. 169
[5] Organic and Biomolecular Chemistry, 2005, vol. 3, # 20, p. 3757 - 3766
3-AMINO-5-BROMOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-AMINO-5-BROMOBENZOIC ACID Suppliers
- Tel
- --
- Fax
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
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View Lastest Price from 3-AMINO-5-BROMOBENZOIC ACID manufacturers
- Product
- 3-AMINO-5-BROMOBENZOIC ACID 42237-85-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-24
- Product
- 3-AMINO-5-BROMOBENZOIC ACID 42237-85-4
- Price
- US $3.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- 3-Amino-5-bromobenzoic acid 42237-85-4
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-25