N-(4-CYANO-PHENYL)-GLYCINE
Description Physical properties- Product Name
- N-(4-CYANO-PHENYL)-GLYCINE
- CAS No.
- 42288-26-6
- Chemical Name
- N-(4-CYANO-PHENYL)-GLYCINE
- Synonyms
- N-(4-Cyanophenyl)glycine(DG10);4-Cyano phenyl Glycine;N-(p-Cyanophenyl)glycine;N-(4-Cynophenyl)-Glycine;Dabigatran Intermediate 2;N-(4-CYANO-PHENYL)-GLYCIN;N-(4-CYANO-PHENYL)-GLYCINE;Glycine, N-(4-cyanophenyl)-;N-(4-Cyanophenyl)glycine >N-(4-Cyanophenyl)glycine, 98%
- CBNumber
- CB51011398
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 42288-26-6.mol
N-(4-CYANO-PHENYL)-GLYCINE Property
- Melting point:
- 237 °C(dec.)
- Boiling point:
- 447.2±30.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.81±0.10(Predicted)
- color
- White to Pale Yellow
- InChI
- InChI=1S/C9H8N2O2/c10-5-7-1-3-8(4-2-7)11-6-9(12)13/h1-4,11H,6H2,(H,12,13)
- InChIKey
- KJRQMXRCZULRHF-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CNC1=CC=C(C#N)C=C1
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C2771
- Product name
- N-(4-Cyanophenyl)glycine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- C2771
- Product name
- N-(4-Cyanophenyl)glycine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $87
- Updated
- 2025/07/31
- Product number
- C982125
- Product name
- N-(4-Cyanophenyl)-glycine
- Packaging
- 5G
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 075705
- Product name
- N-(4-Cyanophenyl)glycine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FC20658
- Product name
- N-(4-Cyanophenyl)-glycine
- Packaging
- 5G
- Price
- $110
- Updated
- 2021/12/16
N-(4-CYANO-PHENYL)-GLYCINE Chemical Properties,Usage,Production
Description
Dabigatran etexilate is a novel synthetic direct thrombin inhibitor, a prodrug of dabigatran, a non-peptide thrombin inhibitor. Dabigatran etexilate intermediate II is an impurity produced during the preparation of dabigatran etexilate.
Physical properties
N-(4-Cyanophenyl)glycine is a off-white Solid.
Uses
Dabigatran etexilate intermediate
Uses
N-(4-Cyanophenyl)-glycine (cas# 42288-26-6) is a compound useful in organic synthesis.
Synthesis
79-08-3
873-74-5
42288-26-6
3.2.3 Preparation of [(4-cyanophenyl)amino]acetic acid (V). Molecular formula: C9H8N2O2. molecular weight: 176.17. Raw materials: 90g (0.75mol) of bromoacetic acid (F), 211.7g (1.5mol) of p-aminobenzonitrile (G), 35g (0.42mol) of sodium bicarbonate. Procedure: bromoacetic acid (F) and p-aminobenzonitrile (G) were mixed in 1250 ml of water to form a suspension. The suspension was placed in a bath heated to 100-110°C for 3 hours. Upon completion of the reaction, the reaction vessel was removed from the bath and cooled to room temperature, followed by further cooling in a refrigerator. The precipitate was separated by diafiltration and dried in a vacuum desiccator at 100 °C. Yield of crude product: 122 g (92.8% yield), HPLC purity: 97%. Purification step: the crude product was converted to sodium salt and re-acidified using aqueous sodium bicarbonate to release the free acid by dilute hydrochloric acid (1:1). After filtration, the product was washed with water and dried in a vacuum desiccator at 105°C. The product was then purified to a sodium salt using aqueous sodium bicarbonate. Yield of purified product: 115 g (88% yield), HPLC purity: 99.1%, water content: 0.13%, sulfated ash: 1.8%.
References
[1] Patent: WO2009/111997, 2009, A1. Location in patent: Page/Page column 11
[2] Patent: WO2013/111163, 2013, A2. Location in patent: Page/Page column 18
[3] Patent: US2015/11589, 2015, A1. Location in patent: Paragraph 0121-0122
[4] European Journal of Medicinal Chemistry, 2016, vol. 120, p. 148 - 159
N-(4-CYANO-PHENYL)-GLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(4-CYANO-PHENYL)-GLYCINE manufacturers
- Product
- N-(4-CYANO-PHENYL)-GLYCINE 42288-26-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 0.001KG
- Purity
- 99.99%
- Supply Ability
- 200000KG
- Release date
- 2025-06-16
- Product
- N-(4-Cyanophenyl)glycine 42288-26-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-10-29
- Product
- N-(4-CYANO-PHENYL)-GLYCINE 42288-26-6
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-14