D-METHAMPHETAMINE Property

Melting point:

143°C (estimate)

Boiling point:

230.33°C (estimate)

Density 

0.9285 (estimate)

refractive index 

1.5105 (estimate)

Flash point:

9℃

storage temp. 

2-8°C

pka

10.38±0.10(Predicted)

Safety

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

16-36/37-45

RIDADR 

1851

WGK Germany 

1

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

537-46-2(Hazardous Substances Data)

Toxicity

A widely abused drug; a sympathomimetic and central stimulant that has been used clinically as an anorectic agent. The use of methamphetamine and related drugs in treating obesity is, however, now generally discredited. It may cause elevation of blood pressure, palpitation, and tachycardia, as well as various CNS effects, including psychotic effects at higher doses. Chronic use of methamphetamine and related compounds, especially at high doses as often occurs with drug abuse, can cause a condition often indistinguishable from schizophrenia. Abrupt withdrawal may cause fatigue, depression, and sleep changes. Methamphetamine is an indirect-acting adrenergic and dopamine agonist that acts principally to release endogenous catecholamines, thereby increasing their synaptic availability. Many of its actions can be blocked by adrenergic and dopamine antagonists. The i.p. LD50 in mice is 70 mg/kg.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

D-METHAMPHETAMINE Chemical Properties,Usage,Production

Originator

Desoxyn ,Abbott Laboratories

Uses

Nasal decongestant.

Definition

ChEBI: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.

Manufacturing Process

2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was treated by eqimolar quantity of hydrochloric acid.

brand name

Amone;Desoxyn;Dexophrine;Dexoval;Doxyfed;Doxyn Drinalfa;Efroxine;Euphrodinal;Gardstat;Gerobit;Geronyl;Lemobese;Madrine;Mediatric;Meloda;Metamsustac;Methampex;Methedrinal;Neodrine-triple;Obedrin-la;Obelones;Obe-slim;Pervitin;Phedrisox;Phelantin;Philopon;Soxympamine;Syndrox;Tonedron;Uno.

Therapeutic Function

Sympathomimetic, Central stimulant

World Health Organization (WHO)

Metamfetamine, an amfetamine derivative, is controlled under Schedule II of the 1971 Convention on Psychotropic Substances. See WHO comment for amfetamine. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)